Toxicity and bioaccumulation of manganese and chromium in different organs of common carp (Cyprinus carpio) fish

Ali, Zeeshan; Yousafzai, Ali Muhammad; Sher, Nadia; Ijaz, Muhammad; Nayab, Gul E; Aqeel, Syed Abdul Maajid; Shah, Syed Touheed; Aschner, Michael; Khan, Ibrar; Khan, Haroon

doi:10.1016/j.toxrep.2021.02.003

Cited by 53 publications

(23 citation statements)

References 31 publications

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“…Out of the three metals examined in this work, only Mn has the potential to bioaccumulate, whilst Ca and Mg are ubiquitous in the body. Most studies on Mn bioaccumulation have been known from fish and plant models, whereby the uptake and buildup of excess Mn is a result of by products being released into the environment due to industrial processes such as welding and gasoline additives [ 12 , 13 ]. At the cellular level, bioaccumulation results in organelle dysfunction, such as lysosomal/vacuolar swelling and oxidative damage to the mitochondria [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid Structure Determines the Differential Impact of Single Metal Additions and Binary Mixtures of Manganese, Calcium and Magnesium on Membrane Fluidity and Liposome Size

Sule

Anikovskiy

Prenner

2023

IJMS

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Unilamellar vesicles of the biologically relevant lipids phosphatidic acid (PA) and phosphatidylserine (PS) with fully saturated (DM-) or partly unsaturated (PO-) acyl side chains were exposed to Ca, Mn and Mg in single metal additions; in equimolar mixtures or by sequential additions of one metal at a time. Laurdan generalized polarization measured the membrane fluidity, while dynamic light scattering reported liposome size changes complemented by zeta potential. All metals induced membrane rigidity and increased liposome sizes across all systems. Mn had the strongest effect overall, but Mg was comparable for DMPS. Lipid side chain architecture was important as GP values for binary mixtures were higher than expected from the sum of values for single additions added to POPS but smaller for DMPS. Sequential additions were predominantly different for Ca:Mg mixtures. Mn induced the strongest increase of liposome size in saturated lipids whereas Ca effects dominated unsaturated matrices. Binary additions induced larger sizes than the sum of single additions for POPS, but much lower changes in DMPA. The order of addition was relevant for PS systems. Thus, lipid structure determines metal effects, but their impact is modulated by other ions. Thus, metal effects may differ with the local lipid architecture and metal concentrations within cells.

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Section: Introductionmentioning

confidence: 99%

Lipid Structure Determines the Differential Impact of Single Metal Additions and Binary Mixtures of Manganese, Calcium and Magnesium on Membrane Fluidity and Liposome Size

Sule

Anikovskiy

Prenner

2023

IJMS

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“…The filtrate was to be analyzed for the presence of AgNPs. For the detection of AgNPs in different organs of fish atomic absorption spectrophotometer (Model: Analyst 700, Parkin Elmer, USA, Serial No: 700S5040102) was used (Ali, Yousafzai, et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Plant based synthesis of silver nanoparticles, antimicrobial efficiency, and toxicological assessment using freshwater fish (Cyprinus carpio)

Khan,

Yousafzai

2023

Microscopy Res & Technique

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Silver nanoparticles (AgNPs) are widely used and have various applications, including medicine, electronics, and textiles. However, their increasing use raises concern about their potential environmental impact, particularly on aquatic organisms, such as fish, which are the primary consumers of aquatic environments and can be exposed to AgNPs through various routes. For this purpose, the leaves of the plant species Bellis perennis were used as a reductive agent to convert silver nitrate into AgNPs, to assess its toxicity against fish. Well‐dispersed and undersized AgNPs were obtained and confirmed using analytical techniques, including Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Moreover, the AgNPs have shown significant antibacterial activity against Aeromonas hydrophila (25.71 ± 0.63) and Vibrio harveyi (22.39 ± 0.29). In addition, the toxicity of the obtained AgNPs was assessed by exposing Cyprinus carpio to various concentrations, including 0.06, 0.1, and 0.2 mg/L. The findings revealed that the AgNPs were significantly accumulated in the intestine, followed by the gills, liver, muscles, kidney, and brain. This bioaccumulation led to histological alterations and destruction in the villi of the intestine, regeneration of liver cells, and degeneration of the gill lamella.Research Highlights Plants based synthesis of AgNPs is mostly considered as eco‐friendly A significant antibacterial activity was obtained The plant mediated AgNPs were found less toxic The AgNPs was profoundly accumulated and causes histological alterations

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“…Also, it exhibits elevated Hb, PCV, RBC, WBC and platelet with increase enzymatic levels during 24-72 hour. After exposure, there was an elevation in the triglycerides (231.21±0.04), serum uric acid (4.81±0.33), high-density lipoprotein (HDL) (39±0.07), glutamic pyruvic transaminase (SGPT) (40.6±0.4), blood urea (13±0.1) and albumin increases the concentration of cholesterol (Ali et al, 2021).…”

Section: Manganese (Mn)mentioning

confidence: 99%

Heavy Metal Pollution in Iraqi Rivers and Impact on Human and Fish Health: A Review

Al-Sarraj¹

2022

Biol. Appl. Environ. Res.

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The Euphrates and Tigris rivers are the main vital water sources in Iraq, and therefore many studies have been conducted on them to find out the reasons for their pollution, and the most important sources of pollution are heavy metals. Heavy metals are usually present in nature. Some of them are necessary for life, but they can become toxic through their accumulation in living organisms, as they cannot be eliminated in ecosystems through natural processes, unlike most organic pollutants, where these elements are one of the dangerous pollutants that enter the freshwater environment and cause an imbalance in the ecological system. This is directly or indirectly reflected on the human beings. These elements enter the plant and animal bodies through the soil, water and air which have been categorized by their ability to bio-accumulate in the tissues of animals and elevate their concentration in the tissue and body fluids. Such bioaccumulation causes toxicity to living organisms and may affect human public health. Fishes are the most susceptible among the aquatic animals to the toxicity of heavy metals. They are a basic food source and animal protein, cheap and economical, with a high nutritional value and the human body needs them on a permanent and continuous basis. Fishes are also commonly used in assessing the health of aquatic organisms. This review is focused on the pathological effects of heavy metals in both fishes and humans.

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Toxicity and bioaccumulation of manganese and chromium in different organs of common carp (Cyprinus carpio) fish

Abstract: Graphical abstract

Cited by 53 publications

References 31 publications

Lipid Structure Determines the Differential Impact of Single Metal Additions and Binary Mixtures of Manganese, Calcium and Magnesium on Membrane Fluidity and Liposome Size

Lipid Structure Determines the Differential Impact of Single Metal Additions and Binary Mixtures of Manganese, Calcium and Magnesium on Membrane Fluidity and Liposome Size

Plant based synthesis of silver nanoparticles, antimicrobial efficiency, and toxicological assessment using freshwater fish (Cyprinus carpio)

Heavy Metal Pollution in Iraqi Rivers and Impact on Human and Fish Health: A Review

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