Toxicité rénale des anticancéreux

Aloy, Blandine; Janus, Nicolas; Isnard-Bagnis, Corine; Deray, Gilbert; Launay‐Vacher, Vincent

doi:10.1016/j.nephro.2021.09.001

Cited by 4 publications

(3 citation statements)

References 86 publications

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“…34 These necrotic tubules may appear alongside the development of progressive kidney disease, characterized by glomerular mesangial sclerosis and tubular degradation. 16 Common brush boundary losses have also been observed in the proximal tubules. In the current study, moderate rates of atypical glomerular structures were also observed.…”

Section: Discussionmentioning

confidence: 98%

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The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation

et al. 2022

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This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues through changes in biochemical and histopathological parameters in addition to contributions to the use of amifostine and RG in clinical studies . Five groups were established: Group I (control, receiving only saline by gavage), Group II (IR only), and Group III (IR+AM, 200 mg/kg intraperitoneally (i.p.). Group IV (IR + RG, 200 mg/kg orally once a day for 4 weeks), and Group V (IR+RG+AM, 200 mg/kg orally once/day for 4 weeks before IR and 200 mg/kg AM administered (i.p.) 30 min before IR). All groups, except for the control group, were subject to 6-Gy whole-body IR in a single fraction. 24 h after irradiation, all animals were sacrificed under anesthesia. IR enhanced MDA, 8-OHdG, and caspase-3 expression while decreasing renal tissue GSH levels ( p < .05). Significant numbers of necrotic tubules together with diffuse vacuolization in proximal and distal tubule epithelial cells were also observed. The examination also revealed substantial brush boundary loss in proximal tubules as well as relatively unusual glomerular structures. While GSH levels significantly increased in the AM, RG, and AM+RG groups, a decrease in KHDS, MDA, 8-OHdG, and caspase-3 expression was observed, compared to the group subject to IR only ( p < .05). Therefore, reactive oxygen species-scavenging antioxidants may represent a promising treatment for avoiding kidney damage in patients receiving radiation.

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Section: Discussionmentioning

confidence: 98%

“…This in turn leads to impaired kidney function. 16 It is therefore essential to protect the kidneys against IR damage.…”

Section: Introductionmentioning

confidence: 99%

The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation

et al. 2022

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“…The pathophysiology and mechanisms underlying this injury are complex and can vary with different drugs. [9][10][11] Cisplatin (CDDP; cis-diamminedichloroplatinum (II)) was the first inorganic platinum anticancer drug to be approved by the FDA and is one of the most common anticancer drugs available clinically. 12 Cisplatin is widely used in the treatment of lung, breast, liver, prostate, and cervical cancers.…”

Section: Introductionmentioning

confidence: 99%

Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects

Zhang,

Gu,

Jiang

et al. 2024

IJN

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Background: Acute kidney injury (AKI) is a syndrome, posing a substantial healthcare burden. The pathological basis of AKI is associated with inflammation and oxidative stress which cause additional damage to mitochondria. Artesunate (ATS) is a derivative of artemisinin isolated from Artemisia annua L. that is an effective treatment for malaria and favored for the prevention and treatment of kidney diseases. However, there are still challenges related to its efficacy, including poor water solubility, limited oral bioavailability and short half-life. Liposome-based nanoparticles are used for drug delivery due to their ideal biocompatibility and their ability to improve the bioavailability of specific drugs and enhance drug efficacy. Methods: In this study, a novel TPP-based natural ATS-nanoliposome, namely T-A-Ls, was applied for the treatment of AKI. ATS was encapsulated with or without triphenylphosphonium (TPP)-modified nanoliposomes. AKI was induced by cisplatin in C57BL/6J mice and a cisplatin-induced injury model was generated in HK-2 cells in vitro. Blood urea nitrogen (BUN), serum creatinine (Scr) measurements and section staining were utilized to assess renal protective effect of T-A-Ls. Inflammatory-related factors and proteins were quantified via Elisa, Immunofluorescence and Western Blot (WB). The anti-mitochondrial oxidative stress effect of T-A-Ls was determined by ROS, JC-1 and oxygen consumption rate (OCR) kits. Immunohistochemistry and WB were conducted to measure associated protein expressions. In vivo biodistribution and the concentration of T-A-Ls in kidney were also explored. Results: T-A-Ls exhibited good oxidative resistance, preferential renal uptake, mitochondrial targeting, and it ameliorated kidney injury in cisplatin-induced AKI mice. Mitochondrial dysfunction, ATP production and respiratory capacity were improved in damaged HK-2 cells; ROS content decreased while mitochondrial membrane potential recovered. T-A-Ls exerted renal protection by inhibiting inflammation and reducing oxidative stress; these effects were mediated by a downregulation in the expression of RAGE and iNOS and an upregulation in both Nrf2 and HO-1. Conclusion:T-A-Ls could improve the delivery of ATS to the kidney, offering a promising avenue to treat AKI.

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How to manage the dose of drugs in cancer patients with acute kidney injury, practical recommendations

Janus,

Desplanques

2023

Int J Clin Pharm

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Toxicité rénale des anticancéreux

Cited by 4 publications

References 86 publications

The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation

The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation

Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects

How to manage the dose of drugs in cancer patients with acute kidney injury, practical recommendations

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