Toxicité maculaire aiguë après consommation de poppers : aspect en SD-OCT

Rabot, A.; Pinon, Fabien; Baillif, S.

doi:10.1016/j.jfo.2012.09.005

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…149,150 Commonly reported ocular effects include a maculopathy, after one or multiple doses. [151][152][153][154][155][156][157][158][159][160][161][162] This typically presents with a subfoveal disruption of ellipsoid layer visible on OCT but may also present with photopsia, central scotomas, decreased visual acuity, vitelliform-like lesion or macular 'microhole'. 157 One report describes a case of full-thickness macular hole, with associated bilateral optic neuritis in a 13year-old, who reported consuming only one dose of poppers.…”

Section: 'Poppers'mentioning

confidence: 99%

Drugs of abuse and ocular effects

Proulx

Tousignant

2021

Clinical and Experimental Optometry

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Illicit drugs and substances of abuse are increasingly used by adults and teenagers, with novel substances constantly becoming available. Many substances can cause ocular effects or visually threatening conditions. Current literature informing eye-care practitioners on these effects is scant. The present scoping review reports the ocular effects of most commonly used drugs and substances of abuse in the teenage and adult populations of North America. Ovid MEDLINE and Ovid EMBASE databases were searched for publications from 1980 to 2019 regarding ocular effects of drug use. The selected papers regarded human subjects, in either teenage or adult population and included all types of studies, including case reports. Publications in English or in French were included. Exclusion criteria were publications about the use of prescriptions drugs, drug withdrawal, and publications about the use of alcohol, tobacco, or cannabis. Some 241 papers were retained and analysed. The use of various drugs and substances can lead to damage to structures throughout the eye, including but not limited to corneal conditions, glaucoma and other optic neuropathies, maculopathies and endophthalmitis. The data presented in this review may help guide clinicians in their diagnosis and treatment of certain ocular conditions, which could otherwise not be linked to drug use.

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Section: 'Poppers'mentioning

confidence: 99%

Drugs of abuse and ocular effects

Proulx

Tousignant

2021

Clinical and Experimental Optometry

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“…PM is more frequently diagnosed in males with very few reports of females suffering from PM (7,25,26). Although hormonal factors may influence this distribution, it probably mirrors male predisposition to use drugs (44) including poppers (23).…”

Section: Risk Factorsmentioning

confidence: 99%

Poppers maculopathy: A quantitative review of previous literature

Martín-Moro

Almagro

Ventura-Abreu

et al. 2021

Seminars in Ophthalmology

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Aim: To review the available literature on poppers maculopathy (PM).Material and methods: 64 patients (60 with bilateral and 4 with unilateral involvement), for a total of 124 eyes reported in Pubmed, Google Scholar and Embase. Patterns were analyzed according to country, age, gender, sexual orientation, HIV status, consumption habits, visual acuity at presentation (VAP), final visual acuity (VAF) and optical coherence tomography (OCT).Results: Most cases (110 eyes) of PM were reported in European countries and affected middle-aged men (only 8 eyes from female users). The median age was 38.7 years (SD=10.5 years). Final visual acuity (Median=0.8; Interquartile range: 0.67-1) was higher than visual acuity at presentation (Median=0.67; Interquartile range: 0.4-0.8). Many articles lack data on sexual orientation and HIV status as this is considered very personal information. VAF was higher than VAP. One third of the eyes (40 eyes) developed PM after a single exposure. No significant differences were found between eyes that developed PM after a single exposure and those which developed the condition after several exposures. The most commonly reported pattern was an interruption of the ellipsoid line (68 eyes).Conclusion: PM is more prevalent in Europe or European ophthalmologists are more likely to diagnose PM. PM usually affects middle-aged men given that this condition generally appears with chronic exposure to poppers. VAF was higher than VAP, suggesting that this toxicity is in part reversible. Information about HIV status was not provided in most recent articles, thus it is not possible to make inferences about the possible implication of HIV drugs as cofactors for the development of this retinal toxicity.

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