Toxicité aiguë de la tomothérapie des cancers mammaires

Aoulad, N.; Massabeau, C.; Lafontan, B. De; Vieillevigne, L.; Hangard, G.; Ciprian, Claudio; Chaltiel, Léonor; Moyal, Elizabeth; Izar, F.

doi:10.1016/j.canrad.2016.11.008

Cited by 9 publications

(10 citation statements)

References 54 publications

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“…The toxicity results described here are comparable with those in the literature for IMRT treatments in adjuvant BC radiotherapy. Previous studies reported skin toxicity in the majority of cases, with most of them being grade 1 reactions (50-84%); no high-grade (≥3) toxicity has been reported [17][18][19][20][21]. In line with these findings, most of the patients in our study experienced a skin reaction (278/288; 96.5%), which was mostly moderate.…”

Section: Discussionsupporting

confidence: 89%

“…Finally, the relatively short follow-up time (median: 2.1 years) did not provide information on late toxicities, especially cardiac and lung chronic side effects, which are expected to be very late events. Some prospective and retrospective studies have been published with a follow-up similar to that of this study [17,21]. One of the secondary objectives of our study was to assess long term toxicity.…”

Section: Discussionmentioning

confidence: 96%

“…Some reports exist regarding esophagitis, yet the number of these reports is very limited. For example, in a retrospective helical IMRT study, Aoulad et al reported 19.9% of grade 1 and 2 acute esophagitis [21].…”

Section: Discussionmentioning

confidence: 99%

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Prospective Study of Intensity-Modulated Radiation Therapy for Locally Advanced Breast Cancer

Bataille

Bennadji

Tinier

et al. 2020

Cancers

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The objective of this study was to evaluate the acute and medium-term toxicities, the quality of life, and aesthetic results of patients with breast cancer (BC) treated with tomotherapy. This was a prospective study, including patients with BC treated by tomotherapy. Radiation therapy delivered 50 Gy in 25 fractions to the breast or chest wall and to lymph node areas, with a simultaneous integrated boost at a dose of 60 Gy at the tumor bed in cases of breast conservative surgery. We included 288 patients, 168 and 120 treated with breast-conserving surgery and mastectomy respectively. Two hundred sixty patients (90.3%) received lymph node irradiation. Median follow-up was 25 months (6–48). Acute dermatitis was observed in 278 patients (96.5%), mostly grade 1 (59.7%). The aesthetic aspect of the breast at one year was reported as “good” or “excellent” in 84.6% of patients. The patients’ quality of life improved over time, especially those treated with chemotherapy. The two-year overall survival and disease-free survival were 97.8% (95% confidence interval (CI): 94.1–99.2%), and 93.4% (95% CI: 89.2–96.0%) respectively. Tomotherapy for locally advanced BC has acceptable toxicity, supporting its use in this indication; however, longer follow-up is needed to assess long-term outcomes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 96%

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Prospective Study of Intensity-Modulated Radiation Therapy for Locally Advanced Breast Cancer

Bataille

Bennadji

Tinier

et al. 2020

Cancers

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“…Only Aoulad et al . performed this analysis, but found no factor associated with acute esophageal toxicity 26 . In our study no variable was significantly associated with esophageal grade ≥2 toxicity.…”

Section: Discussionmentioning

confidence: 94%

“…Aoulad et al . have recently reported the acute toxicity profile of intensity modulated helical tomotherapy during breast cancer irradiation after conserving surgery or mastectomy 26 . Acute grade 1–2 esophageal toxicities occurred in 19.9% of 292 patients.…”

Section: Discussionmentioning

confidence: 99%

Intensity-modulated radiation therapy with simultaneous integrated boost for locally advanced breast cancer: a prospective study on toxicity and quality of life

Pasquier

Tinier

Bennadji

et al. 2019

Sci Rep

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Radiotherapy after breast conserving surgery and mastectomy with node positive disease has been shown to reduce risk of recurrence and mortality in the treatment of breast cancer. Intensity-modulated radiation therapy (IMRT) after conservative surgery offers several advantages over conventional RT including improved acute and late toxicity and quality of life (QoL). We undertook this study to prospectively evaluate acute (≤90 days after last dose of radiotherapy) and long-term (>90 days) cutaneous, esophageal, and fibrosis toxicity and QoL in breast cancer patients treated by adjuvant IMRT after breast surgery. We included patients with complex volumes for which 3D RT does not allow a good coverage of target volumes and sparing organs at risk. We report here an interim analysis with a median follow-up of 13.1 months (range, 6.5–25.9 months). Most of the acute toxicity was cutaneous (95.9%) and oesophageal (59.6%), and mostly grade 1 and 2. Medium-term cutaneous toxicity rate was 25.6%, and mostly grade 1. Medium-term esophageal toxicity was rare (1.8%). In this series acute oesophageal toxicity was found to be associated with dosimetric factors. QoL was well preserved throughout the study, and aesthetic outcomes were good. Based on these data, tomotherapy may be a favorable alternative to other techniques in patients needing a complex irradiation of the breast and lymph node volumes.

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Consommations de tabac et d’alcool chez des femmes traitées pour un cancer du sein dans un service de chirurgie oncologique : des comportements fréquents à considérer

et al. 2022

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Toxicité aiguë de la tomothérapie des cancers mammaires

Cited by 9 publications

References 54 publications

Prospective Study of Intensity-Modulated Radiation Therapy for Locally Advanced Breast Cancer

Prospective Study of Intensity-Modulated Radiation Therapy for Locally Advanced Breast Cancer

Intensity-modulated radiation therapy with simultaneous integrated boost for locally advanced breast cancer: a prospective study on toxicity and quality of life

Consommations de tabac et d’alcool chez des femmes traitées pour un cancer du sein dans un service de chirurgie oncologique : des comportements fréquents à considérer

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