Toxicidad sistémica asociada con la inyección intramuscular de mercurio metálico: reporte de un caso

Mercury is a metal found in the environment from natural and anthropogenic sources. It is highly toxic to ecosystems and living beings. Most human exposures come from ingestion of contaminated seafood, outgassing from dental amalgam or occupational exposure (e.g. gold mining), among other cases. Large populations are exposed to mercury, making it a very important issue from the public health perspective. Adverse health effects are commonly seen in the nervous system, but every organ is a potential target, such as the bone marrow. The main goal of this study was to assess the available evidence on human exposure to mercury and its hematological effects. A search strategy was constructed, including key terms (MeSH, text word and equivalents) for querying 2 repositories of master dissertation and PhD thesis (Fiocruz/ARCA and University of São Paulo) and 4 different electronic databases: BVS/ LILACS, MEDLINE/PubMed, Scopus and TOXLINE/NIH, for articles published from 1950 to February 2018. There was no language restriction and a tool (EPHPP) was used to assess the quality of included studies. According to pre-established criteria, 80 studies were retrieved, all of them observational (48 case reports, 24 cross-sectional, 6 case series and 2 cohorts), comprising 9,284 people. Despite the fact that most exposed ones (6,012) had normal blood cell count and mercury hematological effects did not seem very usual (1,914 cases: 14 severe and 29 deaths), three studies reported association (β) for anemia, lymphopenia, neutrophilia and basophilia. We concluded that the gathered information pointed to mercury hematotoxic effects, some of them may be serious and even fatal.

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Human exposure to mercury and its hematological effects: a systematic review

Vianna

Matos²,

Jesus

et al. 2019

Cad. Saúde Pública

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Uso de succimer como quelante en intoxicación crónica por mercurio: un reporte de caso

Díaz

Arango

Mejía

2020

Rev. Fac. Cienc. Salud Univ. Cauca

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Introducción: La intoxicación crónica por mercurio inorgánico en la industria se presenta con un amplio espectro de manifestaciones clínicas, destacándose las del sistema nervioso central. Este tipo de intoxicaciones requiere el uso de quelantes como pilar del tratamiento para la recuperación de los pacientes afectados. Descripción del caso: A continuación, presentamos un caso de intoxicación crónica por mercurio en una paciente de 33 años quien ingresó al servicio de urgencias con síntomas neurológicos, los cuales mejoraron posterior a la administración de Succimer. Conclusión: Este caso ilustra el uso exitoso del Succimer e invita a la exploración de otros antídotos en Colombia, debido a las pocas opciones disponibles.

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Toxicidad sistémica asociada con la inyección intramuscular de mercurio metálico: reporte de un caso

Cited by 2 publications

References 13 publications

Human exposure to mercury and its hematological effects: a systematic review

Human exposure to mercury and its hematological effects: a systematic review

Uso de succimer como quelante en intoxicación crónica por mercurio: un reporte de caso

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