Toxicant and teratogenic effects of prenatal alcohol

Mahnke, Amanda H.; Adams, Amy M.; Wang, Andrew Z.; Miranda, Rajesh C.

doi:10.1016/j.cotox.2019.08.002

Cited by 9 publications

(10 citation statements)

References 53 publications

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“…Following PAE, an increase in pro-inflammatory microglia in the cortex is found [91]. This increase seems to be triggered in part by EV signaling from developing cortical cells and involvement of TLR4 receptors as mediators of the microglial inflammatory response following PAE [90]. Another study observed that ethanol exposure (70 mM ethanol concentration for 3 days) on ex vivo murine fetal neural stem cells significantly elevates a group of ethanol-sensitive miRNAs in NSC-derived EVs [5].…”

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 96%

“…During the neonatal period of mice, in vivo neural stem cell (NSC)-derived EVs cause a decrease in microglial complexity and an increase in cytokine production due to preferential signaling of microglia [89]. The teratogenic effects of ethanol on the cortex result in alterations of EV signaling pathways [90]. EVs carry a diverse group of molecules that are determined by the EV pathway and environment of their parent cell [82].…”

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

“…During the neonatal period of mice, in vivo neural stem cell (NSC)-derived EVs cause a decrease in microglial complexity and an increase in cytokine production due to preferential signaling of microglia [89]. The teratogenic effects of ethanol on the cortex result in alterations of EV signaling pathways [90]. An in vitro mouse study found that the decrease in miR-21 following ethanol exposure could be the result of an adaptive response to restore neurite outgrowth and decrease in-flammation [53,90].…”

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

“…The teratogenic effects of ethanol on the cortex result in alterations of EV signaling pathways [90]. An in vitro mouse study found that the decrease in miR-21 following ethanol exposure could be the result of an adaptive response to restore neurite outgrowth and decrease in-flammation [53,90]. Following PAE, an increase in pro-inflammatory microglia in the cortex is found [91].…”

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

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Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood

Chung

Pinson

Bhenderu

et al. 2021

IJMS

Self Cite

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Prenatal alcohol exposure (PAE) can have immediate and long-lasting toxic and teratogenic effects on an individual’s development and health. As a toxicant, alcohol can lead to a variety of physical and neurological anomalies in the fetus that can lead to behavioral and other impairments which may last a lifetime. Recent studies have focused on identifying mechanisms that mediate the immediate teratogenic effects of alcohol on fetal development and mechanisms that facilitate the persistent toxic effects of alcohol on health and predisposition to disease later in life. This review focuses on the contribution of epigenetic modifications and intercellular transporters like extracellular vesicles to the toxicity of PAE and to immediate and long-term consequences on an individual’s health and risk of disease.

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Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 96%

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

“…During the neonatal period of mice, in vivo neural stem cell (NSC)-derived EVs cause a decrease in microglial complexity and an increase in cytokine production due to preferential signaling of microglia [89]. The teratogenic effects of ethanol on the cortex result in alterations of EV signaling pathways [90]. An in vitro mouse study found that the decrease in miR-21 following ethanol exposure could be the result of an adaptive response to restore neurite outgrowth and decrease in-flammation [53,90].…”

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

See 2 more Smart Citations

Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood

Chung

Pinson

Bhenderu

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…The prenatal exposure to alcohol can cause developmental deficits, termed fetal alcohol spectrum disorders (FASDs), which include growth deficits and neurodevelopmental delay, affecting cognition and behavior [ 93 , 94 ]. Several studies have already shown the molecular and cellular consequences of chronic alcohol exposure during early embryonic development, such as interference in neural progenitor cell proliferation, neuronal migration and differentiation.…”

Section: Evs In Developmental Pathology Of the Nervous Systemmentioning

confidence: 99%

Extracellular Vesicles in CNS Developmental Disorders

Gomes

Sangani

Fernandes

et al. 2020

IJMS

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The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics.

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Alcoholgebruik en zwangerschap: prevalentie, risico’s en beweegredenen

Smit

2022

TSG Tijdschr Gezondheidswet

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SamenvattingAlcoholgebruik rond de zwangerschap kan negatieve consequenties hebben voor het (on)geboren kind. Voor vrouwen die zwanger willen worden, zwanger zijn of borstvoeding geven luidt het advies dan ook om geen alcohol te drinken – de nulnorm. Dit artikel gaat in op hoe vaak alcoholgebruik rond de zwangerschap voorkomt, risico’s van alcoholgebruik vóór, tijdens en na de zwangerschap, en factoren die samenhangen met alcoholgebruik rond de zwangerschap. Ten slotte wordt besproken hoe (geboortezorg)professionals deze kennis het beste kunnen toepassen en welke (beleids)maatregelen ingezet kunnen worden.

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Toxicant and teratogenic effects of prenatal alcohol

Cited by 9 publications

References 53 publications

Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood

Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood

Extracellular Vesicles in CNS Developmental Disorders

Alcoholgebruik en zwangerschap: prevalentie, risico’s en beweegredenen

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