Toxic substances in foods

Id, Morton

doi:10.3109/09637487709144503

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Therefore, it is not surprising that they contain natural substances unnecessary and sometimes even toxic to man (1). Plant lectins are listed among the naturally occurring food toxicants (2)(3)(4). Lectins have been found to be widely distributed not only in plants, but also in animals and microorganisms.…”

mentioning

confidence: 99%

The lethal protein from kintoki beans (Phaseolus vulgaris) identified as a lectin.

Miyoshi

Nakabayashi

Hara

et al. 1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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mentioning

confidence: 99%

The lethal protein from kintoki beans (Phaseolus vulgaris) identified as a lectin.

Miyoshi

Nakabayashi

Hara

et al. 1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…pointed out that lectins cause growth retardation and even death of experimental animals fed a diet containing a lectin (4)(5)(6)(7)(8). Most lectins, however, lose their toxici ties on heat treatment.…”

mentioning

confidence: 99%

Toxic effects of kintoki bean (Phaseolus vulgaris) lectin on cultured animal cells.

Yawata

Hara

Tsukamoto

et al. 1983

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Effects of a toxic lectin from Kintoki beans (Phaseolus vulgaris, cultivar, Kintoki) on four types of animal cells were investigated. The cells used in this study were mouse L 929, human HeLa S3, and tendon and liver cells from chick embryo. The Kintoki bean lectin agglutinated these cells not only in suspension but also in monolayer, resulting in the marked growth inhibition of these cells. The incorpo rations of 3H-thymidine and 3H-leucine into trichloroacetic acid insoluble fraction of the cells were considerably inhibited by this lectin. There was, however, some lag period before the revelation of the inhibition. Kintoki bean lectin bound to these cells within 1 hr. The type of the lectin receptor seemed uniform for each cell type and the number of the binding sites per cell was different from cell type to cell type. When Kintoki bean lectin was removed from the culture medium, these cells slowly recovered back to normal growth. Key Words toxic lectin, toxicity, cell culture, bean, Phaseolus vulgaris Lectins bind to glycoproteins on the surface of cell membrane and exhibit various biochemical and physiological functions. Therefore, lectins are often used in biochemical studies; binding of specific sugars, precipitation of specific glyco proteins, agglutination of various cells, growth inhibition of tumor cells and stimulation of lymphocyte proliferation (1-3). On the other hand, it has been 65

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Food and Nutrient Exposure throughout the Life Span

Bogle

1998

Handbook of Developmental Neurotoxicology

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Toxic substances in foods

Cited by 3 publications

References 3 publications

The lethal protein from kintoki beans (Phaseolus vulgaris) identified as a lectin.

The lethal protein from kintoki beans (Phaseolus vulgaris) identified as a lectin.

Toxic effects of kintoki bean (Phaseolus vulgaris) lectin on cultured animal cells.

Food and Nutrient Exposure throughout the Life Span

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