Toxic shock syndrome toxin 1(TSST-1) and endotoxin levels in patients with severe sepsis.

Abstract

The plasma TSST-1 and endotoxin levels were measured in 54 samples from 41 septic patients. The plasma TSST-9.8pg/ml in plasma. All patients received direct hemoperfusion with polymixin B-immobilized fiber (PMX) that removes endotoxin from the blood. Mortality was evaluated at 2 weeks after direct hemoperfusion. Forty-six samples (85.2%) were endotoxin positive. Thirty-five samples (64.8%) were TSST-1 positive. Thirty-two samples were both endotoxin and TSST-1 positive. Five samples were both TSST-1 and endotoxin negative. TSST-1 levels and non-survivors. The septic severity score and number of failing organs in the non-survivor group are significantly higher than those in the survivor group. TSST-1 prolonged endotoxin clearance from the blood. In severe sepsis, it is believed that polymicrobial infections are frequently complications and caused the poor prognosis.