Toxic responses to deltamethrin (DM) low doses on gonads, sex hormones and lipoperoxidation in male rats following subcutaneous treatments

Chargui, Issam; Haouem, Samir; Haouas, Zohra; Zaouali, Monia; Hassen, Ben Cheikh

doi:10.2131/jts.34.663

Cited by 68 publications

(40 citation statements)

References 35 publications

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“…Thus the oxidative stress produced by deltamethrin resulted in increased LPO level in liver, kidney, and testis. Increase in LPO and ROS have been previously reported on deltamethrin exposure in liver,[8] plasma, and kidney. [5]…”

Section: Discussionmentioning

confidence: 96%

“…A number of studies on the side effects of deltamethrin have been reported, including neurotoxicity,[21] immunosupression,[22] and reproductive side effects. [8] In addition, hepatotoxicity[23] and nephrotoxicity[24] has also been induced. Dose-dependent system was evaluated in present study.…”

Section: Discussionmentioning

confidence: 99%

“…[35] Issam et al . (2009)[8] have reported reduction in FSH, LH and testosterone in male Wistar rats after deltamethrin treatment. Reduction in testosterone level were also reported by Oda and El-Maddawy (2011)[5] in rats treated with deltamethrin.…”

Section: Discussionmentioning

confidence: 99%

“…Decrease in SOD and CAT were reported by Sakr and Al-Amoudi (2012)[5] in rat kidney, Manna et al . (2005)[8] in liver after deltamethrin administration. Decrease in catalase level was also reported by Sharma and Singh (2010)[41] in rat testis exposed to lindane.…”

Section: Discussionmentioning

confidence: 99%

“…[67] Deltamethtrin has a deleterious effect of on reproductive system. [38] In mammals, spermplasma- membranes have extremely high concentration of polyunsaturated fatty acids and insufficient antioxidant defenses; hence they are highly susceptible to lipid peroxidation. [9]…”

Section: Introductionmentioning

confidence: 99%

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Dose-dependent effect of deltamethrin in testis, liver, and Kidney of wistar rats

Sharma¹,

Singh²,

Jan³

2014

Toxicol Int

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Objectives:Deltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, household pest control, protection of foodstuff, and disease vector control. Although initially thought to be least toxic, a number of recent reports showed its toxic effects in mammalian and non-mammalian animal species. The current study was performed to assess the dose-dependent deltamethrin toxicity on testes, liver, and kidney of male Wistar rats.Materials and Methods:Twenty-four rats were divided in four groups of 6 each. Group A served as normal control. Group B, C, and D were administered with different doses (2 or 3 or 6 mg/kg corresponding to 1/30th or 1/20th or 1/10th of LD50, respectively) of deltamethrin for 28 days.Results:Deltamethrin exposure caused a significant reduction in weight of reproductive organs, decrease in sperm count, sperm motility, serum testosterone (T), follicle stimulating hormones (FSH), and luteinizing hormones (LH) in testis. Glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) were decreased in testis, liver and kidney of exposed rats. Deltamethrin exposure significantly increased sperm abnormalities in testis. Significant increase in lipid peroxidation (LPO) level was observed in testis, liver and kidney. Deltamethrin also caused histological alterations in testes, liver, and kidney.Conclusions:The results indicated that deltamethrin at a dose of 6 mg/kg exerts significant harmful effects on testes, liver and kidney as compare to 2 mg and 3 mg/kg. The study concluded that the system toxicity induced by deltamethrin was dose dependent.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dose-dependent effect of deltamethrin in testis, liver, and Kidney of wistar rats

Sharma¹,

Singh²,

Jan³

2014

Toxicol Int

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Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production

Madhubabu

Yenugu

2013

Environ. Toxicol.

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Pyrethroids are known to be neurotoxic. However, their toxic effects including that of allethrin on the male reproductive tract are not elucidated. Adult male rats were treated orally with 25, 50, 100, and 150 mg/kg body weight allethrin every day for 60 days. Lipid peroxidation was increased (p < 0.001) in the caput, cauda, and testes. Nitric oxide production was increased (p < 0.001) in the caput, but unaltered in the cauda and testes. The activities of catalase, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase were decreased in the caput and cauda where as a decrease was observed in the testis obtained from allethrin treated rats. In the epididymides and testes, damage to tubular architecture, congestion, degeneration of epithelial cell lining, intestinal edema, and presence of dead or degenerating spermatids were observed in a dose dependent manner. The expression profile of genes involved in spermatogenesis (Tgf-beta1), sperm maturation (Spag11e), and sperm function (Defb22) were reduced (p < 0.001) in allethrin rats. The expression of p53 gene was decreased and increased phosphorylation of MAPK (p42/p44) expression was observed the male reproductive tract tissues of allethrin treated rats. Although earlier studies have reported the effects of allethrin inhalation because of the use of mosquito coils and vaporizers, our results for the first time prove that oral exposure to allethrin could affect fertility and may contribute to deregulation of cell cycle in the male reproductive tract.

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Mammal Toxicology of Synthetic Pyrethroids

Tsuji

Yamada

Kawamura

2011

Topics in Current Chemistry

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Pyrethroids show moderate acute oral toxicity in rodents, and their typical toxicological signs are tremors (T syndrome) for Type I (generally non-cyano pyrethroids) and choreoathetosis with salivation (CS syndrome) for Type II (generally α-cyano pyrethroids). However, some pyrethroids show mixed clinical signs. Mainly Type II pyrethroids cause paresthesia, which is characterized by transient burning/tingling/itching sensation of the exposed skin. Also, it has been suggested that some pyrethroids cause developmental neurotoxicity, but available evidence has been judged to be insufficient. While some pyrethroids have been shown to cause tumors in rodent models, the tumor induction does not appear to reflect a common carcinogenic endpoint for this particular subset of compounds. Analysis of carcinogenic mode of action in some cases provides evidence not relevant in humans. Pyrethroids produce no common teratogenic effects in a particular species based on similarity in structure or mode of insecticidal action.

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Toxic responses to deltamethrin (DM) low doses on gonads, sex hormones and lipoperoxidation in male rats following subcutaneous treatments

Cited by 68 publications

References 35 publications

Dose-dependent effect of deltamethrin in testis, liver, and Kidney of wistar rats

Dose-dependent effect of deltamethrin in testis, liver, and Kidney of wistar rats

Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production

Mammal Toxicology of Synthetic Pyrethroids

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