Toxic pyrrolizidine alkaloids provide a warning sign to overuse of the ethnomedicine Arnebia benthamii

Ahmad, Latif; Ying, He; Hao, Jia-Chen; Semotiuk, Andrew J.; Liu, Quan‐Ru; Mazari, Paras

doi:10.1016/j.jep.2017.08.009

Cited by 28 publications

(16 citation statements)

References 34 publications

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“…The cooperatives visited were: "Mtiwa Nabat", "El Baraka", and "Znata koufat". (Ahmad 2018, Eddouks 2017, Sadat-Hosseini et al 2017, Talukdar et al 2017.…”

Section: Data Collectionmentioning

confidence: 99%

“…There is also a high illiteracy rate. We, consequently, helped the respondents understand the questionnaire using languages spoken in each station (Arabic /amazigh) (Ahmad 2018, Aziz et al 2017, Heinrich et al 2018, Prescott et al 2017.The documented information was translated into French and English (Talukdar et al 2017). The population surveyed included farmers, nomads, herbalists, traditional healers and basket makers; we, hence, were able to complete 239 survey forms.…”

Section: Data Collectionmentioning

confidence: 99%

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Socio-economic position of Chamaerops humilis L. var. argentea Andre in the province of Taza (North East Morocco) and impact of the new Moroccan law n° 77-15 (Moroccan Official Bulletin N° 6422) on the preservation of the environment

Lachkar¹,

Lamchouri

Toufik³

2020

Eth Res Appl

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Background: Chamaerops humilis L. var. argentea Andre is a species that exists in abundance in the province of Taza. It is a valuable source of income for the local population, which improves living conditions and reduces poverty. Hence, the importance of highlighting and quantifying the economic interest of this variety for the local population.Methods: In this regard, for the first time, a survey was conducted in the region to assess the socioeconomic importance of Chamaerops humilis, as well as the impact of the new Moroccan law n°77-15 on the ban of the use of plastic bags on its economic position. The study was carried out through a survey using 239 questionnaire sheets in five stations, conducted over two periods before (March-May, 2016) and after (November, 2016-March, 2017) the application of the new law.Results: Our study finds that Chamaerops humilis has a considerable economic value for the local population. The results showed that Chamaerops humilis is an important source of revenue through the sale of the palm heart (43.22 €/week/exploiter), and marketing of artisanal products (Doum baskets: 6.2 €/week/maker). Moreover, the application of the new law had a considerable impact on the basketry market, mainly on the marketing of Doum baskets (14.02 €/week/maker) to replace plastic bags.

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“…The cooperatives visited were: "Mtiwa Nabat", "El Baraka", and "Znata koufat". (Ahmad 2018, Eddouks 2017, Sadat-Hosseini et al 2017, Talukdar et al 2017.…”

Section: Data Collectionmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Socio-economic position of Chamaerops humilis L. var. argentea Andre in the province of Taza (North East Morocco) and impact of the new Moroccan law n° 77-15 (Moroccan Official Bulletin N° 6422) on the preservation of the environment

Lachkar¹,

Lamchouri

Toufik³

2020

Eth Res Appl

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“…7,39,40 However, due to the complicated pathogenesis of HVOD, only a few cases of PA-induced HVOD were confirmed and reported. 41 The latest reported case of PA-induced HVOD in China was a 23-year old woman in 2017. 42 She had taken Runyirong capsules in which S. scandens was contained.…”

Section: Pas In Herbal Plant Samplesmentioning

confidence: 99%

“…The possible reason was that the types and concentrations of PAs in Arnebiae Radix would be varied in different species and different areas. 41 Asteris Radix Et Rhizoma is used as the monarch drug in many prescriptions, such as Zibai Zhisou Capsule and Ziwan Zhike electuary, and these prescriptions are widely used to treat cough and mycoplasma pneumonia, especially for children. 44 However, erucifoline, retrorsine, seneciphylline and echimidine were detected and the total content was 1.84 μg g -1 in Asteris Radix Et Rhizoma, suggesting the potential hepatotoxicity of these prescriptions.…”

Section: Pas In Herbal Plant Samplesmentioning

confidence: 99%

Development of UPLC-Q-TOF-MS Coupled with Cation-exchange Solid-phase Extraction Method for the Determination of Ten Pyrrolizidine Alkaloids in Herbal Medicines

Luo

Wang

et al. 2019

ANAL. SCI.

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Pyrrolizidine alkaloids are secondary metabolites of plants and can cause significant hepatotoxicity in humans. In this study, a fast and simple method was developed to determine ten pyrrolizidine alkaloids (PAs) in six types of herbal medicines using ultra performance liquid chromatography-quadrupole-time of flight mass spectrometry (UPLC-Q-TOF-MS). An efficient solid-phase extraction procedure was carried out by using strong cation-exchange cartridges and the parameters were optimized. The established analytical method was validated and the results showed that the method presented satisfactory accuracy and precision. The established method was successfully applied for the determination of PAs in six herbal plants, including Senecionis Scandentis Hebra, Arnebiae Radix, Asteris Radix Et Rhizoma, Farfarae Flos, Senecionis Cannabifolii Herba and Emilia sonchifolia. PAs were found in all of these herbal plant samples. Eight types of related commercial herbal drugs were also detected, six of them were detected with different amounts of PAs. This work not only provided a powerful technical platform for both qualitative and quantitative analysis of PAs in herbal medicines, but also obtained information concerning PAs in these herbal samples, which could provide reference to the government regulatory authorities and non-governmental organizations.

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“…The alcoholism, smoking and malnutrition also affect healing of wounds [3][4] . Arnebia benthamii is a perennial herb grows in open moist slopes at altitude of 3000 to 3900 meter in India, Pakistan 5 , Afghanistan, and Nepal. In India, the roots of this plant sold under local names Ratanjot, Balchhadi, Laldori, and Laljari, especially in Kinnaur, Chitkul, Chamba, Spiti, and Chanshal regions of Himachal Pradesh, Ladakh, Anantnag, Kargil of Jammu and Kashmir.…”

mentioning

confidence: 99%

Untitled

2020

IJPSR

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Arnebia benthamii (synonym-Microtomia benthamii) commonly known as Ratanjot or Laljari found in western Himalayan region and used as wound healer roots by local vaids and tribes. The roots of Arnebia benthamii contain a red dye that is used in various health disorders like fungal infection, inflammation, fever and coloring/flavoring agent in Indian curries. To estimate wound healing potential of root extract of Arnebia benthamii, percentage wound contraction, wound area, epithelization time, tensile strength and wound index were measured in 13 days of wound healing study. The results showed highly significant wound healing in excision as well as incision wound healing models (P<0.01). The Arnebia benthamii extract-treated wounds showed about 41% higher wound contraction rate and 44% increased tensile strength in comparison with negative control animals. The epithelization time decreased by 43% and wound index value decreased by 89% in comparison to negative control animals which indicated that methanolic root extract of Arnebia benthamii is very helpful in faster and high-quality wound healing (P < 0.05). INTRODUCTION: Plants are traditionally used to treat wounds, cuts, and burns by folklore traditions and tribes all over the world. Modern research showed that plants could heal wounds by various mechanisms like angiogenesis, fibroblast proliferation, up-regulation of iNOS, activation of NF-kB, favour of proinflammatory cytokines, alpha 1 type 1 collagen synthesis or/and antioxidant activity 1. The skin injury by cut, tear or puncture in epidermis or dermis of skin, results in wound 2. Wound healing is a complex process to restore the damaged structures of skin in the injured area.

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Toxic pyrrolizidine alkaloids provide a warning sign to overuse of the ethnomedicine Arnebia benthamii

Cited by 28 publications

References 34 publications

Socio-economic position of Chamaerops humilis L. var. argentea Andre in the province of Taza (North East Morocco) and impact of the new Moroccan law n° 77-15 (Moroccan Official Bulletin N° 6422) on the preservation of the environment

Socio-economic position of Chamaerops humilis L. var. argentea Andre in the province of Taza (North East Morocco) and impact of the new Moroccan law n° 77-15 (Moroccan Official Bulletin N° 6422) on the preservation of the environment

Development of UPLC-Q-TOF-MS Coupled with Cation-exchange Solid-phase Extraction Method for the Determination of Ten Pyrrolizidine Alkaloids in Herbal Medicines

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