Toxic Potency of 3,3′,4,4′,5-Pentachlorobiphenyl Relative to and in Combination with 2,3,7,8-Tetrachlorodibenzo-p-dioxin in a Subchronic Feeding Study in the Rat

Birgelen, A.P.J.M. van; Kolk, J. van der; Fase, K.M.; Bol, I.; Poiger, H.; Brouwer, Abraham; Berg, Martin van den

doi:10.1006/taap.1994.1155

Cited by 67 publications

(30 citation statements)

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“…When PCB126 was administered orally to rats at a daily dose of 10 μ g/kg for 13 weeks, the concentration in adipose tissue was 645 ng/g (Van Birgelen et al 1994). Thus, the amount of PCB126 in the adipose tissue of the present study is estimated to be about 1,000 times higher than that in humans.…”

Section: Discussionmentioning

confidence: 53%

Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats

Orito

Gotanda

Murakami

et al. 2007

Tohoku J. Exp. Med.

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and FUJIWARA, M. Prenatal Exposure to 3,3′,4,4′, Promotes Anxiogenic Behavior in Rats. Tohoku J. Exp. Med., 2007, 212 (2), [151][152][153][154][155][156][157] Polychlorinated biphenyls (PCBs) are environmental contaminants that have adverse effects on the endocrine and nervous systems. As they are still detected in breast milk and adipose tissue in humans, the accumulated PCBs may transfer from mothers to children and damage central nervous system. It is revealed from epidemiological studies that cognitive and motor functions were damaged in children born to mothers who ingested PCBs-contaminated foods. However, it remains unclear whether prenatal exposure to PCBs affects emotionality. In the present study, we therefore examined the effect of prenatal exposure to 3,3′,4, 4′,5-pentachlorobiphenyl (PCB126) on emotionality in rats by focusing on anxiogenic behavior and response of the hypothalamus-pituitary-adrenal axis to stress. Pregnant rats were treated orally with PCB126 at a dose of 30 μ g/kg or corn oil, its vehicle, on gestational day 15, and their male offspring were subjected to the following experiments at 4-5 weeks old. In an open field test, rats with prenatal exposure to PCB126 showed anxiogenic behavioral responses, including decrease in time spent in the center of an open field and the number of rearings and extension of grooming duration. Interactive behavior, which is an index of anxiety level, was shortened in the social interaction test. The increase in the serum corticosterone level induced by forced swim stress was facilitated by prenatal exposure to PCB126. This evidence suggests that PCB126 may exert anxiogenicity on the offspring of exposed dams, and dysfunction of the hypothalamus-pituitary-adrenal axis may at least in part contribute to this abnormality.3,3′,4,4′,5-pentachlorobiphenyl (PCB126); prenatal exposure; anxiogenic; corticosterone

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Section: Discussionmentioning

confidence: 53%

Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats

Orito

Gotanda

Murakami

et al. 2007

Tohoku J. Exp. Med.

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“…In seals and polar bears there are several reports of associations between OHC and lower plasma and hepatic retinol concentrations (Brouwer et al, 1989;Jenssen et al, 1995Jenssen et al, , 2003de Swart et al, 1996;Simms & Ross, 2000;Skaare et al, 2001;Nyman et al, 2002Nyman et al, , 2003Mos et al, 2007). The effects of OHC on the retinol homeostasis have been confirmed in controlled lab studies on rats, mink (Mustela vision) and harbor seals (Phoca vitulina) (Brouwer & Vandenberg, 1986;Chen et al, 1992;Morse & Brouwer, 1995;Van Birgelen et al, 1994;Van der Plas et al, 2001;Brouwer et al, 1989;Martin et al, 2006). OHC and especially polychlorinated biphenyls (PCB) may interfere with transport, storage, metabolism, and excretion of retinoids (de Swart et al, 1994;Simms & Ross, 2000;Jenssen et al, 2003).…”

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confidence: 79%

Organohalogens in A Whale-Blubber-Supplemented Diet Affects Hepatic Retinol and Renal Tocopherol Concentrations in Greenland Sled Dogs (Canis familiaris)

Kirkegaard

Sonne

Jakobsen

et al. 2010

Journal of Toxicology and Environmental Health, Part A

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The aim of this study was to examine the plasma, liver, and kidney status of vitamin A (retinol) and vitamin E (alpha-tocopherol) in two groups of Greenland sled dogs (Canis familiaris), with a total number of 16 bitches and 8 pups. The dogs were fed either minke whale (Balaenoptera acuterostrata) blubber (exposed dogs) or uncontaminated (control group) porcine fat for up to 12 to 21 mo of age. The daily intake of 50-200 g whale blubber (mean: 112 g) constituted between 10.4 and 11.7 microg/kg body weight summation operatororganohalogen contaminants (OHC) (or between 4.6 and 6.1 microg/kg body weight summation operatorpolychlorinated biphenyls [PCB]). Retinol was approximately 18% and alpha-tocopherol 22% higher in the diet of the exposed dogs compared to controls. In adipose tissue, mean of SigmaOHC was 92 ng/g lipid weight (lw) and 5005 ng/g lw for all control (n = 12) and exposed dogs (n = 10), respectively. Hepatic retinol correlated negatively with Sigma-dichlorodiphenyldichloroethane (SigmaDDT) and and Sigma-polybrominated diphenyl ethers (SigmaPBDE) for all exposed animals. A negative correlation between kidney alpha-tocopherol and SigmaPCB concentrations was observed, whereas two positive significant correlations were observed between kidney retinol and Sigma-chlordane-related compounds (SigmaCHL) and dieldrin concentrations. Hepatic alpha-tocopherol concentrations were significantly lower in exposed compared to controls, most likely due to a combination by OHC exposure and high dietary intake of unsaturated fatty acids. These results suggest that dietary exposure from OHC may, even at low concentrations, possibly affect retinol and alpha-tocopherol status in Arctic top predators.

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“…It is known that in rodents, mobilization of retinoid stores by TCDD and DLCs leads to a disruption in retinoid homeostasis and vitamin A deficiency (Van Birgelen et al, 1994Fattore et al, 2000;Schmidt et al, 2003), especially in the liver and lung (Fiorella et al, 1995;Fletcher et al, 2001;Hakansson et al, 1991). Microsomes from several tissues of rats 3 days after a single exposure to TCDD, exhibited increased rates of retinoic acid metabolism with the degree of induction following the order: liver > lung = kidney = testis (Fiorella et al, 1995).…”

Section: Resultsmentioning

confidence: 99%

Pulmonary Lesions in Female Harlan Sprague-Dawley Rats Following Two-Year Oral Treatment with Dioxin-Like Compounds

et al. 2007

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Dioxin and dioxin-related compounds have been associated with high incidences of pulmonary dysfunctions and/or cancers in humans. To evaluate the relative potencies of effects of these compounds, the National Toxicology Program completed a series of two-year bioassays which were conducted using female Harlan Sprague-Dawley rats. The rats were treated orally for up to 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3 ,4,4 , 2,3,4,7,, and a ternary mixture of TCDD, PCB126 and PeCDF. In addition to treatment-related effects reported in other organs, a variety of pulmonary lesions were observed that were related to exposure. Pulmonary CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity was increased in all dosed groups. The most common non-neoplastic lesions, which occurred in all studies, were bronchiolar metaplasia and squamous metaplasia of the alveolar epithelium. Cystic keratinizing epithelioma was the most commonly observed neoplasm which occurred in all studies. A low incidence of squamous cell carcinoma was associated only with PCB126 treatment. Potential mechanisms leading to altered differentiation and/or proliferation of bronchiolar and alveolar epithelia may be through CYP1A1 induction or disruption of retinoid metabolism.

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Toxic Potency of 3,3′,4,4′,5-Pentachlorobiphenyl Relative to and in Combination with 2,3,7,8-Tetrachlorodibenzo-p-dioxin in a Subchronic Feeding Study in the Rat

Cited by 67 publications

References 0 publications

Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats

Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats

Organohalogens in A Whale-Blubber-Supplemented Diet Affects Hepatic Retinol and Renal Tocopherol Concentrations in Greenland Sled Dogs (Canis familiaris)

Pulmonary Lesions in Female Harlan Sprague-Dawley Rats Following Two-Year Oral Treatment with Dioxin-Like Compounds

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