Toxic Megacolon in Ulcerative Colitis

Roth, James L. A.; Valdes-Dapena, A.; Stein, G.; Bockus, Henry L.

doi:10.1016/s0016-5085(19)35411-3

Cited by 76 publications

(19 citation statements)

References 3 publications

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“…PATHOLOGY Two additional criteria were recorded ( Table 1) that reflected the incidence of established or incipient colonic dilatation. These were myocytolysis with transmural capillary engorgement and multiple V-shaped clefts or fissures (Roth et al, 1959). These 5 10 15 20 25 30 (cm) and the other features presented in the Table are now described in more detail.…”

Section: Clinical Activity and Occurrence Of Acute Dilatationmentioning

confidence: 83%

Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'.

Ab¹

1978

J Clin Pathol

383

162

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SUMMARY It is stated that 10-20O,' of cases of non-specific inflammatory bowel disease cannot be classified. Thirty such cases, designated colitis indeterminate at the time of colectomy, were identified from the pathology files of St. Mark's Hospital. The histopathological features of the surgical specimens and any available biopsy specimens were studied. In nearly all the cases urgent surgery had been required and the features of incipient or established fulminating disease were present.

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Section: Clinical Activity and Occurrence Of Acute Dilatationmentioning

confidence: 83%

Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'.

Ab¹

1978

J Clin Pathol

383

162

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show abstract

“…At least two of the following measurements should apply in the 48 hours immediately preceding operation (adapted from Truelove and Witts, 1955;Roth et al, 1959): (1) an oral temperature of over 100°F, (2) a pulse rate greater than 120 per minute, …”

Section: Toxicmentioning

confidence: 99%

“…Only four patients still have successfully functioning ileorectal anastomoses and four patients have died from the effects of the disease. Acute toxic dilatation of the colon has been recognized as a complication of ulcerative colitis for many years (Lumb, Protheroe, and Ramsay, 1955;Roth, Valdes-Dapena, Stein, and Bockus, 1959; Morson and Dawson, 1972) but its occurrence in Crohn's colitis has not been described until recently. We know of only 11 cases of acute toxic dilatation of the colon in Crohn's colitis with reasonably full clinical and pathological details (Schachter, Goldstein, and Kirsner, 1967;McGovern and Goulston, 1968;Javett and Brooke, 1970;Leoutsakos and Pedridis, 1970;Papp and Pollard, 1970;Clark, 1972), and of 18 others without full descriptions (Farmer, Hawk, and Turnbull, 1968;Fielding and Truelove, 1972;Brooke, 1972).…”

mentioning

confidence: 99%

Acute toxic dilatation of the colon in Crohn's colitis

Buzzard¹,

Baker²,

Needham³

et al. 1974

Gut

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“…He recovered steadily without complication and, after his general health had improved substantially, the rectum and remaining sigmoid colon were removed by combined abdomino-perineal excision. ACUTE DILATATION OF THE COLON Ten patients had evidence of marked dilatation of the colon, a complication which has sometimes been termed 'toxic megacolon' (Roth, Valdes-Dapena, Stein, and Bockus, 1959). The attack of ulcerative colitis in which this occurred was usually severe.…”

Section: Part III Complicationsmentioning

confidence: 99%