Toxic Manifestations of Osmium Tetroxide

McLaughlin, A. I. G.; Milton, Ross D.; Perry, Kenneth M. A.

doi:10.1136/oem.3.3.183

Cited by 10 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to its oxidative power, OsO 4 is also used for the treatment of arthritis (Sheppeard and Ward 1980). In contact with organic material, Os forms compounds corresponding to various oxidation states, including the tetravalent dioxide (OsO 2 ) and the metal (McLaughlin 1946;Smith et al 1974). The environmental effects of Os are poorly understood, mainly due to the analytical challenges associated with Os determination at environmentally relevant levels.…”

Section: Introductionmentioning

confidence: 99%

Uptake and Accumulation of Anthropogenic Os in Free-Living Bank Voles (Myodes glareolus)

Rodushkin

Sörlin

Baxter

et al. 2010

Water Air Soil Pollut

View full text Add to dashboard Cite

Osmium tetroxide (OsO 4 ) is one of the most toxic air contaminants but its environmental effects are poorly understood. Here, for the first time, we present evidence of osmium uptake in a common herbivore (bank vole, Myodes glareolus) in boreal forests of northern Sweden. Voles (n=22) and fruticose arboreal pendular lichens, the potential main winter food source of the vole, were collected along a spatial gradient to the west of a steelwork in Tornio, Finland at the Finnish-Swedish border. 187 Os/ 188 Os isotope ratios increased and osmium concentrations decreased in lichens and voles along the gradient. Osmium concentrations in lichens were 10,000-fold higher than those in voles. Closest to the steelwork, concentrations were highest in kidneys rather than skin/fur that are directly exposed to airborne OsO 4 . The kidney-to-body weight ratio was higher at the two localities close to the steelwork. Even though based on a small sample size, our results for the first time demonstrate that osmium is taken up, partitioned, and accumulated in mammal tissue, and indicate that high kidney-to-body weight ratios might be induced by anthropogenic osmium.

show abstract

Section: Introductionmentioning

confidence: 99%

Uptake and Accumulation of Anthropogenic Os in Free-Living Bank Voles (Myodes glareolus)

Rodushkin

Sörlin

Baxter

et al. 2010

Water Air Soil Pollut

View full text Add to dashboard Cite

show abstract

“…Refinery workers, exposed to osmium tetroxide concentrations of 133-640 ,ug/m3 in the fine spray produced in dissolving osmiridium ores in aqua regia, experienced a gritty feeling in the eyes with pain and lacrimation (35). The workers saw large haloes around lights and were unable to read or see motion pictures during the height of the symptoms, which generally subsided within 24 hr.…”

Section: Health Hazardsmentioning

confidence: 99%

“…Asthma and dyspnea were noted by Deville and Debray (34) while they were extracting osmium from osmiridium; by Brunot (23), after opening four 250-mg ampules of osmium tetroxide; and by McLaughlin (35) in one of seven workers studied who were engaged in refining osmiridium. t One authenticated death following accidental inhalation of osmium tetroxide vapor was attributed to bronchial pneumonia (23,36).…”

Section: Health Hazardsmentioning

confidence: 99%

“…Eye irritation in precious-metals workers and among histologists, who use 1-2% osmic acid solutions as a stain, is commonly accompanied by frontal or orbital headache (35).…”

Section: Health Hazardsmentioning

confidence: 99%

“…Osmium has been used with apparently little success, but no ill effects in the treatment of conditions including epithelioma, peripheral neuritis, syphilis, and tuberculosis (35,39).…”

Section: Health Hazardsmentioning

confidence: 99%

See 2 more Smart Citations

Osmium: An Appraisal of Environmental Exposure

Smith¹,

Carson²,

Ferguson³

1974

Environmental Health Perspectives

View full text Add to dashboard Cite

Visualization of Cellular Components in a Mammalian Cell with Liquid-Cell Transmission Electron Microscopy

et al. 2017

View full text Add to dashboard Cite

We present liquid-cell transmission electron microscopy (liquid-cell TEM) imaging of fixed and non-fixed prostate cancer cells (PC3 and LNCaP) with high resolution in a custom developed silicon nitride liquid cell. Fixed PC3 cells were imaged for 90-120 min without any discernable damage. High contrast on the cellular structures was obtained even at low electron doses (~2.5 e-/nm2 per image). The images show distinct structures of cell compartments (nuclei and nucleoli) and cell boundaries without any further sample embedding, dehydration, or staining. Furthermore, we observed dynamics of vesicles trafficking from the cell membrane in consecutive still frames in a non-fixed cell. Our findings show that liquid-cell TEM, operated at low electron dose, is an excellent tool to investigate dynamic events in non-fixed cells with enough spatial resolution (few nm) and natural amplitude contrast to follow key intracellular processes.

show abstract

Toxic Manifestations of Osmium Tetroxide

Cited by 10 publications

References 4 publications

Uptake and Accumulation of Anthropogenic Os in Free-Living Bank Voles (Myodes glareolus)

Uptake and Accumulation of Anthropogenic Os in Free-Living Bank Voles (Myodes glareolus)

Osmium: An Appraisal of Environmental Exposure

Visualization of Cellular Components in a Mammalian Cell with Liquid-Cell Transmission Electron Microscopy

Contact Info

Product

Resources

About