Toxic manifestations of alpelisib in endocrinology. Description of the clinical case
L. M. Kudaeva,
E. E. Kozhedub,
V. O. Kupryshina
et al.
Abstract:Breast cancer (BC) is a serious disease and is considered an important health problem worldwide. The prevalence of the disease in women according to Rosstat was 64,951 cases in the Russian Federation in 2020 (21.7% among all types of cancer). Hormone-dependent estrogen receptor-positive (HR+), human epidermal growth factor receptor type 2 negative (HER2-) metastatic breast cancer (mBC) accounts for 70% of all cases. About 40% of patients with ER+/HER2- mBC have mutations in the PIK3CA gene, leading to hypera… Show more
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