Toxic Hepatitis: a Rare Complication Associated with the use of Ritodrine During Pregnancy

Arcos, F de; Gratacós, E.; Palacio, M.; Cararach, Vicenç

doi:10.3109/00016349609033327

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…There are several publications describing the association between ritodrine and acute liver injury. One prospective study reported that ritodrine was rarely associated with liver function impairment, even when intravenous ritodrine was administered in 128 pregnant women [ 27 ]. In that study, the incidence of acute liver injury in singleton and multiple pregnancies was approximately 1.9% and 9.1%, respectively.…”

Section: Discussionmentioning

confidence: 99%

A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: a case report

Wu,

Huang,

Tsai

et al. 2024

BMC Pregnancy Childbirth

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Background Ritodrine hydrochloride is a widely used beta-adrenergic agonist used to stop preterm labor in Taiwan. Many side effects causing maternal morbidity and mortality have been reported. We report a case complicated with ritodrine-induced side effects and mirror syndrome that was associated with placental chorioangioma. Case presentation A 36-year-old singleton pregnant woman at 25 6/7 weeks of gestation, with an undiagnosed placental chorioangioma, underwent tocolysis due to preterm uterine contractions. Her clinical condition deteriorated, attributed to mirror syndrome and adverse events induced by ritodrine. An emergency cesarean section was performed at 27 1/7 weeks of gestation, delivering an infant with generalized subcutaneous edema. A placental tumor measuring 8.5 cm was discovered during the operation, and pathology confirmed chorioangioma. Gradual improvement in her symptoms and laboratory data was observed during the postpartum period. Identifying mirror syndrome and ritodrine-induced side effects poses challenges. Therefore, this case is educational and warrants discussion. Conclusion Our case demonstrates mirror syndrome induced by chorioangioma, which is rare, and ritodrine-induced side effects. The cessation of intravenous ritodrine and delivery are the best methods to treat maternal critical status due to fluid overload.

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Section: Discussionmentioning

confidence: 99%

A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: a case report

Wu,

Huang,

Tsai

et al. 2024

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…There are several publications describing the association between ritodrine and acute liver injury. One prospective study reported that ritodrine was rarely associated with liver function impairment, even when intravenous ritodrine was administered in 128 pregnant women [25]. In that study, the incidence of acute liver injury in singleton and multiple pregnancies was approximately 1.9% and 9.1%, respectively.…”

Section: Ritodrine-induced Acute Liver Injurymentioning

confidence: 95%

A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: A case report

Wu,

Huang,

Tsai

et al. 2023

Preprint

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Background: Ritodrine hydrochloride is a widely used beta-adrenergic agonist used to stop preterm labor in Taiwan. Many side effects causing maternal morbidity and mortality have been reported. We report a case complicated with ritodrine-induced side effects and mirror syndrome that was associated with placental chorioangioma.Case presentation: A 36-year-old singleton pregnant woman at 25 6/7 weeks of gestation was administered continuous intravenous ritodrine for preterm uterine contractions. After one week of tocolytics, she presented with elevated serum levels of creatinine kinase (CK), acute kidney injury, impaired liver function and pulmonary edema. Ultrasound showed hydrops fetalis, polyhydramnios and placental thickening. Because of progressive dyspnea and rhabdomyolysis, emergency cesarean section was performed at 27 1/7 weeks of gestation. A 1000-g female infant with general subcutaneous edema was delivered and had an Apgar score of 1 at 1 min and 3 at 5 min. In addition, an 8.5-cm placental chorioangioma was found during the operation. After cesarean section and the cessation of intravenous ritodrine, her symptoms and laboratory indicators improved gradually during the postpartum period. It is difficult to identify mirror syndrome and ritodrine-induced pulmonary edema. Thus, this case is educational and worthy of discussion.Conclusion: Our case demonstrates mirror syndrome induced by chorioangioma, which is rare, and ritodrine-induced side effects. The cessation of intravenous ritodrine and delivery are the best methods to treat maternal critical status due to fluid overload.

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Liver Diseases and Pregnancy

Burroughs¹

2007

Textbook of Hepatology

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Toxic Hepatitis: a Rare Complication Associated with the use of Ritodrine During Pregnancy

Abstract: Elevation of liver enzymes is a rare complication of ritodrine. Discontinuation of therapy does not appear to be indicated as long as other signs of liver dysfunction are not present and tocolytic treatment is required.

Cited by 7 publications

References 5 publications

A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: a case report

A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: a case report

A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: A case report

Liver Diseases and Pregnancy

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