Toxic Epidermal Necrolysis

Pasricha, JS; Khaitan, Binod K.; Shantharaman, R.; Mital, Asit; Girdhar, Mukesh

doi:10.1111/j.1365-4362.1996.tb01674.x

Cited by 23 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier mortality rate of patients with TEN in our department was 35% and 58.3%, respectively (EC et al; unpublished observation). Drugs such as cyclosporin A, cyclophosphamide, plasmapheresis and N-acetylcysteine have currently been proposed for the treatment of TEN (13 -16), including the use of corticosteroid, which remains controversial (17,18). The induction of extensive keratinocyte apoptosis is now considered to be the main key feature of the pathogenesis.…”

Section: Discussionmentioning

confidence: 98%

Unusual Spindle Cell Squamous Carcinoma in a Renal Transplant Patient

Kurzen¹,

Zeier²,

Zelger³

et al. 2003

Acta Dermato-Venereologica

View full text Add to dashboard Cite

High-dose intravenous immunoglobulin has been proposed as an alternative treatment for several immuno-mediated inflammatory skin diseases, usually at a dosage of 1 - 2 g/kg. We describe the treatment of 10 patients affected by toxic epidermal necrolysis using 400 mg/kg per day on 5 consecutive days--a schedule that is lower than previously reported schedules. According to the SCORTEN, the earlier predicted mortality rate was 35%. After high-dose intravenous immunoglobulin therapy, a mortality rate of 10% and a survival rate of 90% were reached. In particular, nine patients showed a dramatic improvement already after one course of infusion started at an early stage of the disease. It is our experience, and that of others, that high-dose intravenous immunoglobulin can be considered the drug of first choice for toxic epidermal necrolysis, one of the most severe life-threatening dermatological conditions, and a valid alternative therapy for different long-standing chronic dermatological diseases. This therapy can also be effective in avoiding high steroid dosages and consequently steroid-related or immunosuppressive-related side effects. It is therefore reasonable to propose high-dose intravenous immunoglobulin treatment as a valuable therapeutic tool for dermatologists.

show abstract

Section: Discussionmentioning

confidence: 98%

Unusual Spindle Cell Squamous Carcinoma in a Renal Transplant Patient

Kurzen¹,

Zeier²,

Zelger³

et al. 2003

Acta Dermato-Venereologica

View full text Add to dashboard Cite

show abstract

“…It is managed as an acute emergency. The administration of corticosteroids in treatment of TEN is still controversial;19 20 however, may be helpful in short courses if given early. Antibiotics are given only if there is evidence of infection.…”

Section: Discussionmentioning

confidence: 99%

Lamotrigine-induced toxic epidermal necrolysis in a young epileptic

Sofi

Koul²,

Mufti³

et al. 2011

Case Reports

View full text Add to dashboard Cite

“…High doses of systemic corticosteroids are to be given for a minimum possible period to prevent secondary bacterial infection. Such high dose systemic corticosteroids have been found to be effective and life-saving by many other workers as well (2)(3). Some workers have even tried corticosteroid pulse therapy (16).…”

Section: Case Reportmentioning

confidence: 99%

Stevens‐Johnson Syndrome with Idiopathic Thrombocytopenic Purpura Treated with Dexamethasone Pulse Therapy

Barman,

Verma,

Agrawal

et al. 2003

The Journal of Dermatology

View full text Add to dashboard Cite

Stevens‐Johnson syndrome (SJS) is a severe, episodic, acute, mucocutaneous hypersensitivity reaction often caused by drugs. We herewith report a case of SJS with idiopathic thrombocytopenic purpura (ITP) that did not respond to daily oral prednisolone therapy. When treated with dexamethasone pulse therapy, the response was found to be very good. Therefore, we concluded that dexamethasone pulse therapy can be a good and an effective alternative therapy for treatment of such patients. However, to establish its role, further trials in more patients are needed.

show abstract

Toxic Epidermal Necrolysis

Abstract: Corticosteroids used in an appropriate dosage schedule constitute an important component of the treatment for TEN to ensure early recovery.

Cited by 23 publications

References 24 publications

Unusual Spindle Cell Squamous Carcinoma in a Renal Transplant Patient

Unusual Spindle Cell Squamous Carcinoma in a Renal Transplant Patient

Lamotrigine-induced toxic epidermal necrolysis in a young epileptic

Stevens‐Johnson Syndrome with Idiopathic Thrombocytopenic Purpura Treated with Dexamethasone Pulse Therapy

Contact Info

Product

Resources

About