Toxic epidermal necrolysis in the absence of circulating T cells: A possible role for resident memory T cells

Safety of cephalosporins in penicillin class severe delayed hypersensitivity reactions

“…Further, the absence of IFN-γ positivity in all skin test positive patients may reflect the known absence of circulating drug-reactive effector memory T-cells despite durable long-lasting tissue-resident memory T cells responses being evident in vivo. 10 This work confirms a previously infrequently described pattern of cross-reactivity between penicillins in severe T-cell mediated penicillin hypersensitivity and provides support for cephalosporin tolerability in these populations. Future work needs to be directed at understanding the antigenic structures and genomic predictors in these severe penicillin-associated T-cell mediated hypersensitivities.…”

Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease

“…To assess host T cells in gut, a retrospective cohort study (Supplemental Table 2) of 15 male patients transplanted with female donor grafts who were diagnosed clinically and histopathologically with acute colonic GVHD cells (SJD, unpublished observations and ref. 17). Given the apparent durability of tissue-resident T cells, we hypothesized that host tissue-resident T cells survive HSCT conditioning and play a previously unappreciated role in GVHD.…”

Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions

“…Severe T cell-mediated hypersensitivity reactions are associated with significant morbidity and mortality (Trubiano et al, 2016), yet the immunopathogenesis remains ill-defined, and there is no consensus regarding optimal therapy. Previous case reports have noted an absence of circulating drug-reactive T cells in severe T cellmediated cutaneous reactions (Iriki et al, 2014), raising the possibility that skin-resident T RM cells are key mediators of such skin hypersensitivity reactions. Moreover, recent work has shown that a reduction in T RM cell function after immune checkpoint blockade therapy may reduce the severity of the nondrug hypersensitivity disease allergic contact dermatitis (Gamradt et al, 2019).…”