Toxic Epidermal Necrolysis From Atorvastatin

Pfeiffer, Carmen; Kazenoff, S; H, Rothberg

doi:10.1001/jama.279.20.1613-a

Cited by 31 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been 6 reports of statin-induced exfoliative dermatitis in the literature, including TEN, but none of the studies tested for HLA-related genes. [ 9 , 10 , 11 , 12 , 13 , 14 ] In addition, it is mentioned on the atorvastatin drug label that it may cause TEN in extremely rare cases. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

Toxic epidermal necrolysis in a patient on atorvastatin therapy expressing human leukocyte antigen alleles

Jiang

et al. 2021

Medicine

View full text Add to dashboard Cite

Rationale: Toxic epidermal necrolysis (TEN) is a rare, severe mucosal response of the skin associated with a high mortality rate. TEN is most commonly caused by drugs, and is characterized by extensive skin epidermal exfoliation. Patient concerns: A 68-year-old woman presented with a rash that had persisted for four days. The patient who had undergone a mitral valve replacement 1 month prior and was taking atorvastatin at the time of admission. Diagnoses: The patient exhibited more than 30% exfoliation surfaces and the severe drug eruption was considered to be TEN. According to human leukocyte antigen (HLA) allele detection and ALDEN score, HLA alleles which found in this case report may be an cause of TEN induced by atorvastatin. Interventions: All drugs used prior to admission were discontinued and the patient was given antiallergic drugs. Outcomes: After 3 weeks following Antiallergic treatment, the rash on patient's calf had subsided, the edema was relieved, and the patient was no longer experiencing pain. After 60 days following discharge, the patient's skin has regrown. Lessons: This is the first report describing the induction of TEN by atorvastatin in a HLA alleles carrier. For HLA alleles carrier, atorvastatin may need to be used with caution to avoid TEN. Future systematic research is also required to confirm this finding and avoid similar serious skin adverse reactions.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxic epidermal necrolysis in a patient on atorvastatin therapy expressing human leukocyte antigen alleles

Jiang

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…In spite of this evidence, it is possible that the adverse reaction was associated with administration of valsartan, hydrochlorothiazide, atorvastatin, pioglitazone and glibenclamide. Only atorvastatin has been documented as causing erythema multiforme, as well as Stevens-Johnson syndrome or toxic epidermal necrolysis [8]. Therefore, the role of valsartan, hydrochlorothiazide, atorvastatin, pioglitazone and glibenclamide was questioned, but the patient had received these drugs for 3 years.…”

Section: Discussionmentioning

confidence: 99%

Generalised erythematous skin eruptions induced by sorafenib: cutaneous toxicity and treatment outcome

et al. 2008

View full text Add to dashboard Cite

A woman diagnosed of a renal cell carcinoma in 1989 had a metastatic kidney cancer localised in subcutaneous nodules, gut and lung in 2007. Sorafenib treatment was initiated a 400 mg orally twice a day. The patient developed generalised erythematous skin eruptions and two weeks later a widespread erythematous maculopapular eruption located exclusively on the legs and arms, along with an objective response. The most likely cause of the generalised erythematous skin eruptions was considered to be sorafenib because of the close temporal relationship between exposure to the drug and onset of symptoms. Furthermore, a relationship between sorafenib skin toxicity and treatment efficacy was observed. This therapeutic efficacy of EGFR inhibitors and cutaneous side effects should be better assessed in large cohorts or trials to determine whether the skin toxicity of patients can be linked to an objective antitumour response.

show abstract

“…Atorvastatin is reported to induce linear IgA bullous dermatosis, 78 and toxic epidermal necrolysis 79 …”

Section: Adverse Effectsmentioning

confidence: 99%

“…76,77 Atorvastatin is reported to induce linear IgA bullous dermatosis, 78 and toxic epidermal necrolysis. 79 Spiny keratoderma is a dermatosis consisting of multiple projections located on the palms and soles, which was reported in six cases treated with statins. 80 Lovastatin could increase the sensitivity to UVA radiation in cultured human N.C.T.C.…”

Section: Adverse Effectsmentioning

confidence: 99%

Statins in dermatology

Jowkar

Namazi

2010

Int J Dermatology

View full text Add to dashboard Cite

Statins are competitive inhibitors of 3-hydroxy-3-methylyglutaryl-coenzyme A reductase and reduce low-density lipoprotein-C levels. Statins are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Statins possess anti-inflammatory, immunomodulatory, antioxidant, metabolic, and possible anticancer effects. Statins are reported to be effective against psoriasis, dermatitis, graft-versus-host disease, uremic pruritus, vitiligo, and hirsutism. Topical forms of statins are employed in the treatment of acne, seborrhea, rosacea, and rhinophyma. Animal studies show the beneficial effect of statins against contact dermatitis and wound healing. They have promising anti-HIV effects as well. This article succinctly reviews the various cellular and molecular effects of statins, their applications in cutaneous medicine and their side effects.

show abstract

Toxic Epidermal Necrolysis From Atorvastatin

Cited by 31 publications

References 0 publications

Toxic epidermal necrolysis in a patient on atorvastatin therapy expressing human leukocyte antigen alleles

Toxic epidermal necrolysis in a patient on atorvastatin therapy expressing human leukocyte antigen alleles

Generalised erythematous skin eruptions induced by sorafenib: cutaneous toxicity and treatment outcome

Statins in dermatology

Contact Info

Product

Resources

About