Toxic Epidermal Necrolysis

Toxic epidermal necrolysis (the scalded skin syndrome): A reappraisal

“…The best evidence for drugs causing TEN is accumulated clinical experience, certain drugs recurring as suspects, until suspicion becomes probability, and probability approaches certainty (Rostenberg et al, 1968;B6ttiger, 1975). Sulphonamides (Bergoend et al, 1968;Kauppinen, 1972), pyrazolones (Overton, 1962;Manganotti, 1964), barbiturates (Durand et al, 1964;Stuttgen, 1973) and anti-epileptics (Ruskin, 1948;Bailey et al, 1965) are examples. There were 92 suspected drugs in the list prepared by Bandmann (1970).…”

Toxic epidermal necrolysis associated with pentazocine therapy and severe reversible renal failure

“…In this case the uraemia was most likely explained by hypovolaemia secondary to fluid loss into indurated skin and from denuded areas; this being supported by the finding of a low urinary sodium and a dramatic response to volume replacement with plasma and saline. It has been pointed out (Schuppli, 1970;Hoigne, 1970) that prompt and adequate parenteral fluid and electrolyte replacement is essential, particularly as such disturbances are likely to be factors influencing the mortality (Bailey, Rosenbaum & Anderson, 1965;Braun-Falco, 1970). We know of no case where recovery occurred after such a degree of uraemia.…”

Le syndrome de Lyell

“…1959; Lee et al, 1952: Rowell et Thomp son, 1961Bazex et al, 1962;Kitske et Baumgartner, 1962;Bailey et al, 1965], ou encore intra-et/ou sous-épidermique [Beare, 1962;Lyell, 1956Lyell, , 1967Frain-Bell et Koblenzer. 1961 ;7ak et al, 19647ak et al, : Lowney et al, 1967.…”