Toxic elements in well water from Malaysia

Kato, Masaya; Onuma, Shoko; Kato, Yoko; Thắng, Nguyễn Đình; Yajima, Ichiro; Hoque, Muhammad Ziaul; Shekhar, Hossain Uddin

doi:10.1080/02772241003707454

Cited by 23 publications

(11 citation statements)

References 12 publications

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“…The As contamination in Malaysia did not reach the level of concern to the public at that time. However, the concentration levels of As of 19 % of well water samples from Sabah in 2010 showed levels exceeding those in the WHO health-based guidelines (Kato et al 2010). This indicates that the As level in Malaysia had increased throughout the years due to human activities.…”

Section: Introductionmentioning

confidence: 96%

An investigation of arsenic contamination in Peninsular Malaysia based on Centella asiatica and soil samples

Ong

Yap

Mahmood

et al. 2012

Environ Monit Assess

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The first objective of this study was to provide data of arsenic (As) levels in Peninsular Malaysia based on soil samples and accumulation of As in Centella asiatica collected from 12 sampling sites in Peninsular Malaysia. The second objective was to assess the accumulation of As in transplanted C. asiatica between control and semi-polluted or polluted sites. Four sites were selected which were UPM (clean site), Balakong (semi-polluted site), Seri Kembangan (semi-polluted site) and Juru (polluted site). The As concentrations of plant and soil samples were determined by Instrumental Neutron Activation Analysis. The As levels ranged from 9.38 to 57.05 μg/g dw in soils, 0.21 to 4.33 μg/g dw in leaves, 0.18 to 1.83 μg/g dw in stems and 1.32-20.76 μg/g dw in roots. All sampling sites had As levels exceeding the CCME guideline (12 μg/g dw) except for Kelantan, P. Pauh, and Senawang with P. Klang having the highest As in soil (57.05 μg/g dw). In C. asiatica, As accumulation was highest in roots followed by leaves and stems. When the As level in soils were higher, the uptake of As in plants would also be increased. After the transplantation of plants to semi-polluted and polluted sites for 3 weeks, all concentration factors were greater than 50 % of the initial As level. The elimination factor was around 39 % when the plants were transplanted back to the clean sites for 3 weeks. The findings of the present study indicated that the leaves, stems and roots of C. asiatica are ideal biomonitors of As contamination. The present data results the most comprehensive data obtained on As levels in Malaysia.

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Section: Introductionmentioning

confidence: 96%

An investigation of arsenic contamination in Peninsular Malaysia based on Centella asiatica and soil samples

Ong

Yap

Mahmood

et al. 2012

Environ Monit Assess

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“…More than 25 million and 11 million patients with arsenicosis have been reported in Bangladesh and Vietnam, respectively (Chowdhury et al 2000;Berg et al 2007). Previous epidemiological studies have revealed that various cancers are explosively increasing in patients with arsenicosis who drink arsenic-polluted well water (IARC 1980(IARC , 2004Kato et al 2010;Smith et al 1992). As revealed by results of previous autoradiographic animal studies showing accumulation of arsenic in the skin and hair after chronic exposure (Lansdown 1995), cutaneous squamous cell carcinoma (SCC) is one of the representative arsenic-mediated cancers.…”

Section: Introductionmentioning

confidence: 98%

Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells

et al. 2012

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Our fieldwork showed more than 1 μM (145.1 μg/L) barium in about 3 μM (210.7 μg/L) arsenic-polluted drinking well water (n = 72) in cancer-prone areas in Bangladesh, while the mean concentrations of nine other elements in the water were less than 3 μg/L. The types of cancer include squamous cell carcinomas (SCC). We hypothesized that barium modulates arsenic-mediated biological effects, and we examined the effect of barium (1 μM) on arsenic (3 μM)-mediated apoptotic cell death of human HSC-5 and A431 SCC cells in vitro. Arsenic promoted SCC apoptosis with increased reactive oxygen species (ROS) production and JNK1/2 and caspase-3 activation (apoptotic pathway). In contrast, arsenic also inhibited SCC apoptosis with increased NF-κB activity and X-linked inhibitor of apoptosis protein (XIAP) expression level and decreased JNK activity (antiapoptotic pathway). These results suggest that arsenic bidirectionally promotes apoptotic and antiapoptotic pathways in SCC cells. Interestingly, barium in the presence of arsenic increased NF-κB activity and XIAP expression and decreased JNK activity without affecting ROS production, resulting in the inhibition of the arsenic-mediated apoptotic pathway. Since the anticancer effect of arsenic is mainly dependent on cancer apoptosis, barium-mediated inhibition of arsenic-induced apoptosis may promote progression of SCC in patients in Bangladesh who keep drinking barium and arsenic-polluted water after the development of cancer. Thus, we newly showed that barium in the presence of arsenic might inhibit arsenic-mediated cancer apoptosis with the modulation of the balance between arsenic-mediated promotive and suppressive apoptotic pathways.

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“…In fact, tens of millions of patients with arsenicosis have been reported in residents who drink arsenic-polluted well drinking water in the world (National-Research-Council, 1999;IARC, 2004). Previous epidemiological studies showed that various cancers are increasing in patients with arsenicosis (IARC, 1980(IARC, , 2004Smith et al, 1992;Kato et al, 2010;Yajima et al, 2012). Cutaneous squamous cell carcinoma is one of the representative cancers induced by arsenic (Lansdown, 1995;IARC, 2004).…”

Section: Introductionmentioning

confidence: 99%

Arsenite-Mediated Promotion of Anchorage-Independent Growth of HaCaT Cells through Placental Growth Factor

Yajima

Kumasaka

Ohnuma³

et al. 2015

Journal of Investigative Dermatology

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Various cancers including skin cancer are increasing in 45 million people exposed to arsenic above the World Health Organization's guideline value of 10 μg l(-1). However, there is limited information on key molecules regulating arsenic-mediated carcinogenesis. Our fieldwork in Bangladesh demonstrated that levels of placental growth factor (PlGF) in urine samples from residents of cancer-prone areas with arsenic-polluted drinking water were higher than those in urine samples from residents of an area that was not polluted with arsenic. Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities. The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway. Moreover, arsenite proteasome-dependently degrades metal-regulatory transcription factor-1 (MTF-1) protein, resulting in a decreased amount of MTF-1 protein binding to the PlGF promoter. MTF-1 negatively controlled PlGF transcription in HaCaT cells, resulting in increased PlGF transcription. These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes. Thus, this study proposed a molecular mechanism for arsenite-mediated development of skin cancer.

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Toxic elements in well water from Malaysia

Cited by 23 publications

References 12 publications

An investigation of arsenic contamination in Peninsular Malaysia based on Centella asiatica and soil samples

An investigation of arsenic contamination in Peninsular Malaysia based on Centella asiatica and soil samples

Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells

Arsenite-Mediated Promotion of Anchorage-Independent Growth of HaCaT Cells through Placental Growth Factor

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