Toxic effects of waterborne nitrite exposure on antioxidant responses, acetylcholinesterase inhibition, and immune responses in olive flounders, Paralichthys olivaceus, reared in bio-floc and seawater

Kim, Jun-Hwan; Kim, Su Kyoung; Hur, Young Baek

doi:10.1016/j.fsi.2019.12.059

Cited by 36 publications

(14 citation statements)

References 36 publications

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“…Mohamed et al [46] reported a significant decrease in the GST activity of Nile tilapia, O. niloticus, after hexavalent chromium exposure, and suggested that a decrease in GST is induced by the stimulation of the biotransformation process. In previous studies, oxidative stress caused by toxic exposure to various environmental stresses increased the GST activity in various fish species [3,27,36]; however, in the present study, the observed decrease in GST activity is thought to have been due to exhaustion from the excessive removal of free radicals. In other words, it is judged that the decrease in GST is due to a functional loss on account of the generation of active oxygen in excess of the ability of the antioxidant enzyme.…”

Section: Discussioncontrasting

confidence: 78%

“…These authors suggested that GSH depletion was caused by the oxidation of GSH to GSSH to protect the cells from free radicals, which indicates an activation of the antioxidant function in response to nitrite exposure. Kim et al [3] also reported a significant decrease in the GSH level of olive flounders, P. olivaceus, exposed to nitrite. Lin et al [48] also reported a significant decrease in the GSH level of zebrafish, Danio rerio, exposed to nitrite, for the purpose of ROS elimination.…”

Section: Discussionmentioning

confidence: 91%

“…Nitrite is a critical toxic substance for organisms in the aquatic environment that is generated in the process of bacterial nitrification of ammonia or the denitrification of nitrate [1]. Generally, nitrite presently occurs at low concentrations in the aquatic environments, but can significantly increase in high-density aquaculture or eco-friendly aquaculture systems, such as Recirculating Aquaculture Systems (RAS) and bio-floc technology (BFT) [2,3]. Imbalance in nitrification activity of bacteria, such as Nitrosomonas and Nitrobacter species, results in nitrite accumulation in the aquaculture environment [4].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Nitrite Exposure on the Hematological Properties, Antioxidant and Stress Responses of Juvenile Hybrid Groupers, Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀

2022

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Nitrite concentrations can reach high levels in indoor aquaculture systems, thus it is vital to determine the nitrite tolerance of aquaculture fish species. Here, juvenile hybrid groupers (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀, Family: Serranidae) were exposed to waterborne nitrite at 0, 10, 20, 40, and 80 mg NO2−/L for 2 weeks. Nitrite exposure caused significant reductions in hematocrit and hemoglobin levels, significant increases in plasma calcium and plasma ALP levels, but had no significant effects on magnesium and total protein levels. Of the antioxidant responses investigated, SOD activity increased significantly in the liver and gills, but GST activity and GSH levels were significantly inhibited by nitrite exposure. Stress indicators, such as plasma cortisol and HSP 70 levels, were significantly stimulated by nitrite exposure. In brief, nitrite exposure over 20 mg NO2−/L had toxic effects and affected the hematological properties, antioxidant responses, and stress indicators of juvenile hybrid groupers.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Effects of Nitrite Exposure on the Hematological Properties, Antioxidant and Stress Responses of Juvenile Hybrid Groupers, Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀

2022

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“…It has been reported that the accumulation of feed residues in the culture pond led to the increase of content of ammonia nitrogen and nitrite [ 34 ]. In addition, the water quality factors such as nitrate and nitrite are related to disease [ 35 , 36 ], immunity [ 37 , 38 ] and metabolism [ 39 , 40 ] and should be carefully monitored in aquaculture.…”

Section: Discussionmentioning

confidence: 99%

Key Factors Affecting the Flesh Flavor Quality and the Nutritional Value of Grass Carp in Four Culture Modes

Zhang

Kaneko

Sun

et al. 2021

Foods

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Flavor and nutritional value are important qualities of freshwater fish products, but the key factors affecting these quality parameters remain unclear. In this study, four typical aquaculture modes, including the commercial feed treatment (control), faba bean treatment (FBT), grass powder treatment (GPT), and waving water treatment with commercial feed (WWT), were used to explore the regulatory effect of water quality and feed (eaten and uneaten) on the flesh flavor and nutrition in grass carp (Ctenopharyngodon idella), a freshwater fish of the largest global production. During the culture period (90 days), water quality parameters of the four modes were measured every 15 days, and the flavor quality was evaluated by volatile flavor compounds detection and electronic nose analyzer. Flesh crude protein, crude fat, free fatty acid and free amino acid profiles were also determined. The results showed that, in the late period, the FBT mode had the poorest water quality with highest concentrations of nitrite and nitrate, while the GPT mode has the best water quality among the four modes. Most flesh flavor compounds found in the flesh of the control, GPT and WWT modes were pleasant. In the FBT mode with the poorest water quality, on the other hand, we found lower flavor quality (higher contribution of fishy compounds), higher water content, and lower contents of crude protein, crude fat, free fatty acids and free amino acids, compared to the other three modes. Correlation analyses showed that nitrite and nitrate are probably key water quality factors affecting the flavor quality and nutritional values besides eaten feed and uneaten feed factors. This study can serve as an important reference for ecological regulation and feeding administration of flesh quality in freshwater aquaculture fish.

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“…This elevated nitrite concentration is toxic to fish. Evidence from many studies suggests that nitrite can interfere with ionic balance and induce oxidative stress in organisms by increasing the generation of reactive oxygen species (ROS) and suppressing the immune response [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Antioxidant response can be used as a good indicator to evaluate toxicity in aquatic animals [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Acute Nitrite Exposure on Physiological Stress Response, Oxidative Stress, Gill Tissue Morphology and Immune Response of Large Yellow Croaker (Larimichthys crocea)

Zhang

Guo

et al. 2022

Animals

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Nitrite is a common pollutant in aquaculture water, and nitrite toxicity that negatively affects aquatic species is common in aquaculture systems when the water quality is low. Therefore, the present research aimed to evaluate the effect of acute nitrite exposure on the hematological parameters, antioxidant enzymes, immune response, and gill morphology of large yellow croaker (Larimichthys crocea). The fish were randomly separated and exposed to four (i.e., 0, 29.36, 58.73, and 88.09 mg/L) nitrite concentrations for 48 h. The fish blood and gills were collected at 0, 12, 24, 36, and 48 h of nitrite exposure for further analysis. In hematological parameters, the results showed that the levels of hemoglobin, triglyceride, and total cholesterol in blood significantly decreased (p < 0.05) in all nitrite-treated samples after 12 h, while the contents of methemoglobin in blood significantly increased (p < 0.05) in these treatments. After 48 h of nitrite exposure, the levels of cortisol in serum showed a 94.5%, 132.1%, and 165.6% increase in fish exposed to 29.36, 58.73, and 88.09 mg/L nitrite, respectively. The nitrite (i.e., 29.36, 58.73, and 88.09 mg/L) exposure significantly increased (p < 0.05) the levels of antioxidant enzymes (i.e., catalase and glutathione) in the gill and serum after 12 h of exposure compared with the control. The lysozyme levels in serum decreased in the nitrite (i.e., 29.36, 58.73, and 88.09 mg/L) exposure samples. It was found that immunoglobulin levels in the 29.36, 58.73, and 88.09 mg/L nitrite-treated samples (i.e., 1.86, 1.58, and 0.74 ug/mL, respectively) were lower than that of the control (2.56 ug/mL). In addition, the surface of the gill lamellae displayed deformation and contraction after 48 h of nitrite, especially in the fish exposed to 88.09 mg/L nitrite. These results indicate that the nitrite exposure induced the oxidative stress, affected the immune response, and changed the gill morphology, leading to nitrite poisoning in large yellow croaker.

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Toxic effects of waterborne nitrite exposure on antioxidant responses, acetylcholinesterase inhibition, and immune responses in olive flounders, Paralichthys olivaceus, reared in bio-floc and seawater

Cited by 36 publications

References 36 publications

Effects of Nitrite Exposure on the Hematological Properties, Antioxidant and Stress Responses of Juvenile Hybrid Groupers, Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀

Effects of Nitrite Exposure on the Hematological Properties, Antioxidant and Stress Responses of Juvenile Hybrid Groupers, Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀

Key Factors Affecting the Flesh Flavor Quality and the Nutritional Value of Grass Carp in Four Culture Modes

Analysis of Acute Nitrite Exposure on Physiological Stress Response, Oxidative Stress, Gill Tissue Morphology and Immune Response of Large Yellow Croaker (Larimichthys crocea)

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