Toxic effects of waterborne benzylparaben on the growth, antioxidant capacity and lipid metabolism of Nile tilapia (Oreochromis niloticus)

Lin, Hongxing; Jia, Yongyi; Han, Fenglu; Xia, Chuyan; Zhao, Qun; Zhang, Jiliang; Li, Erchao

doi:10.1016/j.aquatox.2022.106197

Cited by 9 publications

(3 citation statements)

References 68 publications

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“…To maintain the original exposure concentration, 80% of the water in each tank was renewed daily. According to our previously reported methods [ 15 ], actual BuP concentrations ( n = 3) in the control group and BuP exposure groups were measured each week using an LC/MS/MS system connected to an AB SCIEX QTRAP 5500 tandem quadrupole mass spectrometer (QTRAP ® 5500, Mundelein, IL, USA). The actual concentrations of BuP were 0, 5.19 ± 0.12, 50.26 ± 0.46, 518.33 ± 5.67, and 5286.67 ± 303.33 ng/L in control, 5 ng/L BuP, 50 ng/L BuP, 500 ng/L BuP, and 5000 ng/L BuP groups.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, different doses of butylparaben (BuP) were chosen according to previous studies [ 14 , 15 , 16 ] to evaluate the effects of BuP on skin pigmentation in Nile tilapia. Skin pigmentation-related hormones, neurotransmitter levels, and genes related to phototransduction were measured to reveal the underlying mechanisms involved in BuP-induced abnormal skin pigmentation by interfering with the neuroendocrine system.…”

Section: Introductionmentioning

confidence: 99%

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Butylparaben Exposure Induced Darker Skin Pigmentation in Nile Tilapia (Oreochromis niloticus)

Liu

Zhang

Liang³

et al. 2023

Toxics

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Butylparaben (BuP), as an emerging contaminant with endocrine-disrupting effects, may exert effects on skin pigmentation in fish by interfering with the neuroendocrine system. Therefore, models of BuP exposure in Nile tilapia (Oreochromis niloticus) were established by adding different doses of BuP (0, 5, 50, 500, and 5000 ng/L) for 56 days. The obtained results showed that BuP exposure induced darker skin pigmentation, manifested as increased melanin content of skin, while genes related to melanin synthesis, including α-MSH and Asip2, significantly changed. In addition, BuP exposure reduced dopamine and γ-aminobutyric acid content in the brain, which is related to the synthesis of α-MSH. Furthermore, the release of neurotransmitters from the brain is affected by light. Thus, the relative gene expression levels in the phototransduction pathway were evaluated to explore the molecular mechanism of BuP-induced darker skin pigmentation, and the obtained results showed that Arr3a and Arr3b expression was significantly upregulated, whereas Opsin expression was significantly downregulated in a BuP dose-dependent manner, indicating that BuP inhibited phototransduction from the retina to the brain. Importantly, correlation analysis results showed that all melanin indexes were significantly positively correlated with Arr3b expression and negatively correlated with Opsin expression. This study indicated that BuP induced darker skin pigmentation in Nile tilapia via the neuroendocrine circuit, which reveals the underlying molecular mechanism for the effects of contaminants in aquatic environments on skin pigmentation in fish.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Butylparaben Exposure Induced Darker Skin Pigmentation in Nile Tilapia (Oreochromis niloticus)

Liu

Zhang

Liang³

et al. 2023

Toxics

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“…Incorporating fish oil into fish diets provides the cultured fish, particularly Tilapia species, with dietary energy and the essential fatty acids they require. According to Lin et al (2022), a combination of fish oil and maize oil in the diet of Grouper (Epinephelus malabaricus) has a significant impact on growth and non-specific immunological responses. In order to increase growth and food conversion ratio, as well as the palatability of the feeds for the fish, 2-3% fish oil is added as an additive to Tilapia fish feeds during feed formulation.…”

Section: Fish Oilsmentioning

confidence: 99%

A Review on the Current Status and Emerging Trends in the Utilization of Fish Feed Additives for Sustainable Production of Oreochromis Niloticus

Rahman,

Ashraful Alam,

Moniruzzaman

et al. 2023

Am. J. Aquac. Anim. Sci.

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Feed additives are regarded as an essential component of the fish diet during the production of fish feed. The addition of feed additives to fish food is essential for enhancing the growth and immunity of farmed fish. This study’s objective was to conduct a comprehensive review of the Current Status and Trends in the Adoption of these fish feed additives for Sustainable Tilapia production. In this study, an exploratory research design was used to review and comprehend numerous peer-reviewed papers published in national and international publications on issues related to fish feed additives currently used in Tilapia aquaculture production and the current and future prospects of essential fish feed additives. Feed additives are ingredients that are added in minor amounts to fish diets to increase nutrient content and prolong shelf life. Preservatives, binders, feeding stimulants, and food coloring are frequent feed additives. In order to optimize the production of farmed fish, it is necessary to encourage the use of additives as aquaculture expands. The purpose of feed additives in fish feed is to promote healthier and more rapid fish growth in aquaculture. As a result, fish diets must include the proper amounts of feed additives. The findings imply that fish feed without feed additives is analogous to “a vehicle without fuel” and should be regarded as poor fish feed when fed to fish in an aquaculture system. The end consequence will be a low growth rate for fish, decreased disease resistance, and consequently low productivity in an aquaculture production system.

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NCI677397 targeting USP24‐mediated induction of lipid peroxidation induces ferroptosis in drug‐resistant cancer cells

Wang,

Wu,

Yang

et al. 2023

Molecular Oncology

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Cancer represents a profound challenge to healthcare systems and individuals worldwide. The development of multiple drug resistance is a major problem in cancer therapy and can result in progression of the disease. In our previous studies, we developed small‐molecule inhibitors targeting ubiquitin‐specific peptidase 24 (USP24) to combat drug‐resistant lung cancer. Recently, we found that the USP24 inhibitor NCI677397 induced ferroptosis, a type of programmed cell death, in drug‐resistant cancer cells by increasing lipid reactive oxygen species (ROS) levels. In the present study, we investigated the molecular mechanisms and found that the targeting of USP24 by NCI677397 increased gene expression of most lipogenesis‐related genes, such as acyl‐CoA synthetase long‐chain family member 4 (ACSL4), and activated autophagy. In addition, the activity of several antioxidant enzymes, such as glutathione peroxidase 4 (GPX4) and dihydrofolate reductase (DHFR), was inhibited by NCI677397 treatment via an increase in protein degradation, thereby inducing lipid ROS production and lipid peroxidation. In summary, we demonstrated that NCI677397 induced a marked increase in lipid ROS levels, subsequently causing lipid peroxidation and leading to the ferroptotic death of drug‐resistant cancer cells. Our study provides new insights into the clinical use of USP24 inhibitors as ferroptosis inducers (FINs) to block drug resistance during chemotherapy.

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Toxic effects of waterborne benzylparaben on the growth, antioxidant capacity and lipid metabolism of Nile tilapia (Oreochromis niloticus)

Cited by 9 publications

References 68 publications

Butylparaben Exposure Induced Darker Skin Pigmentation in Nile Tilapia (Oreochromis niloticus)

Butylparaben Exposure Induced Darker Skin Pigmentation in Nile Tilapia (Oreochromis niloticus)

A Review on the Current Status and Emerging Trends in the Utilization of Fish Feed Additives for Sustainable Production of Oreochromis Niloticus

NCI677397 targeting USP24‐mediated induction of lipid peroxidation induces ferroptosis in drug‐resistant cancer cells

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