Toxic effects of polystyrene nanoplastics and polybrominated diphenyl ethers to zebrafish (Danio rerio)

Wang, Qiuping; Li, Yizheng; Chen, Yurou; Tian, Liyan; Gao, Dandan; Liao, Hongping; Kong, Chunmiao; Chen, Xikun; Junaid, Muhammad; Wang, Jun

doi:10.1016/j.fsi.2022.05.025

Cited by 26 publications

(6 citation statements)

References 65 publications

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“…Our findings revealed that PSN might enter an organism body and remain there for a long period in different organs or cells, perhaps leading to organ functional deterioration. 100 Additionally, in order to comprehend the underlying process and ecological danger, the toxicity or biological impacts associated with the internal dispersion of nanoparticles are crucial. 97 In comparison to the concentration in the aqueous solution, the cumulative concentration of PSN in the tissues will have stronger negative impacts.…”

Section: Resultsmentioning

confidence: 99%

Qualitative and quantitative analysis of accumulation and biodistribution of polystyrene nanoplastics in zebrafish (Danio rerio) via artificial freshwater

Habumugisha,

Zhang,

Ndayishimiye

et al. 2023

Environ. Sci.: Nano

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Section: Resultsmentioning

confidence: 99%

Qualitative and quantitative analysis of accumulation and biodistribution of polystyrene nanoplastics in zebrafish (Danio rerio) via artificial freshwater

Habumugisha,

Zhang,

Ndayishimiye

et al. 2023

Environ. Sci.: Nano

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“…As an emerging pollutant, nanoplastics have attracted more and more attention for their potential toxicity to aquatic organisms and mammals (Prata et al 2020). PS-NPs aggravated the endocrine disrupting effect of triphenyl phosphate (TPhP) in zebra sh (He et al 2021) and increased the developmental toxicity of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) (Wang et al 2022), also able to increase (synergistically) heavy metal toxicity in sh (Santos et al 2022). Many studies have detected the adsorption and accumulation of chemical pollutants on MPs in the surrounding environment, but relatively speaking, the more important toxicity mechanism of NPs is chemical toxicity (Machado et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Polystyrene nanoplastic exposure enhances LPS-induced lung inflammation in mice by inducing M1 polarization of macrophages via ROS/JAK/STAT signaling pathway

Fan

Peng

et al. 2022

Preprint

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Nanoplastics (NPs) are an emerging environmental pollutant. NPs can spike various tissues results to oxidative stress and tissue damage in organisms. While recent studies have reported a relationship between nanoparticles and respiratory system injury, the specific mechanism of NP exposure-induced lung damage remains to be explored. In the present study, C57BL6 male mice were treated intraperitoneal injection of PS-NPs and/or LPS. The relevant indicators were detected by HE staining, western blotting and qRT-PCR. RAW264.7 was pretreated with JAK2 inhibitor (AG490) to verify whether the JAK2/STAT3 signaling pathway is involved in PS-NPs exposure enhances LPS-induced pulmonary inflammatory response. We found decreased antioxidant capacity in mice lungs, activation of the JAK2/STAT3 pathway, and the expression levels of macrophage M1 marker genes increased (including CD16, CD86, and MCP1), while macrophage M2 marker genes (including CD206, PPARγ, and Arg1) expression levels decreased, resulting in a macrophage M1/M2 imbalance. In addition, PS-NPs can increase the expression of inflammation-related factors IL-1β, TNF-α and IL-6. In in vitro experiments, we obtained similar results to in vivo experiments. More importantly, the JAK2 pathway inhibitor AG490 reversed ROS-induced changes in macrophage imbalance and inflammation in PS-NPs and LPS-exposed RAW264.7 cells. In conclusion, PS-NPs activated the ROS/JAK/STAT pathway, aggravated LPS-induced lung M1/M2 macrophage imbalance and promoted inflammatory responses. Our results enrich the toxic effects and related molecular mechanisms of NPs-induced lung inflammation, and provide new insights into the toxic effects of NPs on mammals.

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“…For example, the addition of MPs increased the genotoxicity of Cd to zebrafish (Lu et al, 2018). In addition, Teng (2018) found a significant increase in DNA damage values in ctenophore cells after the addition of 2‐μm PS compared to a single decabromodiphenyl ether exposure. Paul‐Pont et al (2016) found that fluoranthene increased genotoxicity in muscle cells in the presence of MPs.…”

Section: Genotoxicity Of Mpsmentioning

confidence: 99%

Research progress on the cellular toxicity caused by microplastics and nanoplastics

Yang

et al. 2023

J of Applied Toxicology

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Microplastics (MPs) are plastic particles of a diameter of less than 5 mm and a major carrier of pollution. In accordance with its diameter range, MPs can be divided into microplastics (100–5 mm) and nanoplastics (<100 nm). In recent years, in addition to the impact of MPs on the environment, the ways in which MPs affect the body has also attracted continuous attention. However, relevant studies on the cytotoxicity of MPs are not comprehensive. Based on the current research, this paper summarizes four main cytotoxic mechanisms of MPs, inducing oxidative stress, damaging cell membrane organelles, inducing immune response, and genotoxicity. Generally, MPs cause cytotoxicity such as oxidative stress, damage to cell membranes and organelles, activation of immune responses, and genotoxicity through mechanical damage or induction of cells to produce reactive oxygen species. Understanding these toxic mechanisms is helpful for the evaluation and prevention of human toxicity of MPs. This paper also analyzes the limitations of current research and prospects for future research into cellular MPs, with the aim of providing a scientific basis and reference for further research into the toxic mechanism of MPs.

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Toxic effects of polystyrene nanoplastics and polybrominated diphenyl ethers to zebrafish (Danio rerio)

Cited by 26 publications

References 65 publications

Qualitative and quantitative analysis of accumulation and biodistribution of polystyrene nanoplastics in zebrafish (Danio rerio) via artificial freshwater

Qualitative and quantitative analysis of accumulation and biodistribution of polystyrene nanoplastics in zebrafish (Danio rerio) via artificial freshwater

Polystyrene nanoplastic exposure enhances LPS-induced lung inflammation in mice by inducing M1 polarization of macrophages via ROS/JAK/STAT signaling pathway

Research progress on the cellular toxicity caused by microplastics and nanoplastics

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