Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia

Zychowski, Katherine E.; Wheeler, Abigail; Sanchez, Bethany; Harmon, Molly; Tyler, Christina R. Steadman; Herbert, Guy; Lucas, Selitá; Ali, Abdul-Mehdi S.; Avasarala, Sumant; Kunda, Nitesh K.; Robinson, Paul D.; Muttil, Pavan; Cerrato, José M.; Bleske, Barry E.; Смирнова, O. K.; Campen, Matthew J.

doi:10.1007/s12012-019-09507-y

Cited by 10 publications

(3 citation statements)

References 39 publications

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“…In an associated study, mice were exposed to PM 10 collected from this mining region. This exposure resulted in some degree of pulmonary inflammation and lung injury in the mice due to inhaling metals in airborne particles ( Zychowski et al., 2019 ). Collectively, metal ions bound in airborne particles pose adverse health effects to mice and humans, and the oftentimes-overlooked residential scenario could lead to unexpected risks.…”

Section: Discussionmentioning

confidence: 99%

An overlooked route of inhalation exposure to tap water constituents for children and adults: Aerosolized aqueous minerals from ultrasonic humidifiers

2020

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Fine particulates and aerosols emitted by commonly used, room-sized ultrasonic humidifiers may pose adverse health effects to children and adults. The literature documents adverse effects for children exposed to minerals emitted from humidifiers. This study performs novel and comprehensive characterization of bivariate particle size and element concentrations of emitted airborne aerosols and particles from ultrasonic humidifiers filled with tap water, including size distribution from 0.014 to 10 μm by scanning mobility particle sizer and AeroTrak; corresponding metal and elemental concentrations as a function of particle size by inductively coupled plasma mass spectrometer; and calculations of deposition fraction in human lungs for age-specific groups using the multi-path particle dosimetry model (MPPD). Deposition fraction is the ratio of mass deposited to total mass inhaled. When filled with tap water, water evaporated from emitted aerosols to form submicron particles that became essentially “dried tap water” with median size 146 nm and mean concentration of 211 μg-total elements/m 3 -air including 35 μg-calcium/m 3 -air in a room of 33.5 m 3 and air exchange rate at ∼0.8 hr −1 . Approximately 90% of emitted particles deposited in human lungs were <1 μm as shown by MPPD model. The smaller particles contained little water and higher concentration of minerals, while larger particles of >1 μm consisted of lower elemental concentrations and more water due to low evaporation. Deposition fraction in pulmonary region was ∼2-fold higher, and deposited particulate mass was 3.5-fold higher for children than adults, indicating greater inhalation exposure to children compared to adults. Modeled data of total particles mass per body weight (BW) that will deposit in adult and child lungs after 8-h humidifier exposure were respectively 2.8 μg/kg-BW and 9.8 μg/kg-BW, where calcium contributes 0.4 μg/kg-BW and 1.6 μg/kg-BW. This comprehensive study of bivariate inorganic chemical composition as a function of particle size expanded, quantified, and modeled exposure for children and adults to aerosolized calcium and other inorganic constituents in water.

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Section: Discussionmentioning

confidence: 99%

An overlooked route of inhalation exposure to tap water constituents for children and adults: Aerosolized aqueous minerals from ultrasonic humidifiers

2020

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“…This cross-sectional study indicates that U-mining is associated with upregulation of soluble VCAM-1 and VCAM-1 mRNA expression, as measured by the SCIP assay, even after adjusting for individual, confounding covariates such as age, diabetes, HbA1c, or statin usage. U and other metals' exposure are key contributors to the development of chronic vascular diseases and vascular events [26,27]. In this pilot study, we found that Uminers exhibited both upregulated cell adhesion molecules such as ICAM-1 and VCAM-1, which mediate leukocyte recruitment into organs following radiation exposure [28].…”

Section: Key Features Of These Findingsmentioning

confidence: 78%

VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners

Assad

Shore

Myers

et al. 2021

Life

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The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the molecular basis for this phenomenon is currently unknown. In this pilot study, a New Mexico (NM)-based occupational cohort of current and former miners (n = 44) were recruited via a mobile screening clinic for miners. Serum- and endothelial-based endpoints were used to assess circulating inflammatory potential relevant to CVD. Non-U miners reported significantly fewer pack years of smoking than U-miners. Circulating biomarkers of interest revealed that U-miners had significantly greater serum amyloid A (SAA), soluble intercellular adhesion molecule 1 (ICAM-1, ng/mL), soluble vascular cell adhesion molecule 1 (VCAM-1, ng/mL), and VCAM-1 mRNA expression, as determined by the serum cumulative inflammatory potential (SCIP) assay, an endothelial-based assay. Even after adjusting for various covariates, including age, multivariable analysis determined that U-miners had significantly upregulated VCAM-1 mRNA. In conclusion, VCAM-1 may be an important biomarker and possible contributor of CVD in U-miners. Further research to explore this mechanism may be warranted.

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“…The inhalation of respirable particulate matter (PM) is considered one of the top global health risks for cardiorespiratory mortality and morbidity by the World Health Organization and the Global Burden of Disease project . Populations, such as the many indigenous communities in the southwestern United States, reside in close proximity to mine waste sites and, as a result, are at especially high risk of heavy metal-rich PM exposure. − Documented health hazards in communities located close to mine sites include hypertension and cardiovascular and kidney diseases, all of which are associated with metal-bearing PM exposure. , Recent findings in a Navajo population indicate that residential proximity to abandoned uranium (U) mine sites results in increased serum inflammatory potential . However, associations between inflammation and ingested metals were not detected, suggesting that inhalation may represent a critical, but understudied factor in these populations …”

Section: Introductionmentioning

confidence: 99%

Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity

Hayek

Medina

Guo

et al. 2021

Environ. Sci. Technol.

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Particulate matter (PM) presents an environmental health risk for communities residing close to uranium (U) mine sites. However, the role of the particulate form of U on its cellular toxicity is still poorly understood. Here, we investigated the cellular uptake and toxicity of C-rich U-bearing particles as a model organic particulate containing uranyl citrate over a range of environmentally relevant concentrations of U (0–445 μM). The cytotoxicity of C-rich U-bearing particles in human epithelial cells (A549) was U-dose-dependent. No cytotoxic effects were detected with soluble U doses. Carbon-rich U-bearing particles with a wide size distribution (<10 μm) presented 2.7 times higher U uptake into cells than the particles with a narrow size distribution (<1 μm) at 100 μM U concentration. TEM-EDS analysis identified the intracellular translocation of clusters of C-rich U-bearing particles. The accumulation of C-rich U-bearing particles induced DNA damage and cytotoxicity as indicated by the increased phosphorylation of the histone H2AX and cell death, respectively. These findings reveal the toxicity of the particulate form of U under environmentally relevant heterogeneous size distributions. Our study opens new avenues for future investigations on the health impacts resulting from environmental exposures to the particulate form of U near mine sites.

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Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia

Cited by 10 publications

References 39 publications

An overlooked route of inhalation exposure to tap water constituents for children and adults: Aerosolized aqueous minerals from ultrasonic humidifiers

An overlooked route of inhalation exposure to tap water constituents for children and adults: Aerosolized aqueous minerals from ultrasonic humidifiers

VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners

Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity

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