Toxic effects of non-steroidal anti-inflammatory agents in rats

Abstract

The toxicosis of some non-steroidal anti-inflammatory drugs, piroxicam, indomethacin, phenylbutazone, and aspirin, which

Biological effects of different doses of Piroxicam in albino males rats

“…There were decreasing in Hb and PCV values this may be due to effect of Piroxicam in synthesis of DNA which effect on protein synthesis [16], due to side effect of piroxicam This result are in agreement with [20] after administration of some NSAIDs drugs.…”

Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus rattus) and house mice (Mus musculus)

“…Indomethacin and its metabolites have highly irritating effect on gastrointestinal tract and ulcerogenic sequel, and frequency and severity of damages depend on the amount of indomethacin excreted with bile, which is different for every animal species. The higher bile excretion in rodents is considered as one of the main reasons for its high toxicity in synanthropic rodents (11,17).…”

“…Concerning the effectiveness of the indomethacin baits in practice, Abatan et al (11) and Maitai & Muneng (17) inform that in many West African countries indomethacin is traditionally used in the fight against rodents and with very good results, but their use is not officially reglamented and they are not patented as rodenticidal products. They emphasize that indomethacin baits are cheaper, more affordable and safer in comparison with other rodenticides, (e.g., zinc phosphide and brodifacum).…”

“…It is proven that application of indomethacin can lead to development of aplastic anemia. Indomethacin is also hepato-and nephrotoxic, expressed in formation of liver necrosis and rapidly developing acute renal failure (after intake of high doses) or interstitial nephritis (11). NSAIDs' ulcerogenic effect is probably due to the inhibited synthesis of mucopolysaccharides, covering and protecting the gastrointestinal mucosa from the activity of hydrochloric acid and digestive enzymes and also from the inhibited synthesis of some prostaglandins with cytoprotective effect on mucosa.…”

“…NSAIDs' ulcerogenic effect is probably due to the inhibited synthesis of mucopolysaccharides, covering and protecting the gastrointestinal mucosa from the activity of hydrochloric acid and digestive enzymes and also from the inhibited synthesis of some prostaglandins with cytoprotective effect on mucosa. It is proven that most NSAIDs directly damage the gastrointestinal mucosa by causing apoptosis and necrosis of enterocytes (11,12). Kesyakova (13) and Pahwa (14) found that bromadiolone and warfarin baits, potentiated with indomethacin have higher toxicity, and death occurs within shorter period and after consumption of lower dosage, compared to baits without indomethacin.…”