Toxic effects of nano-TiO2 in bivalves—A synthesis of meta-analysis and bibliometric analysis

Emerging investigator series: metal nanoparticles in freshwater: transformation, bioavailability and effects on invertebrates

“…109 As filter feeders, bivalves represent one of the most important pathways of MNPs into the human food chain. 35,110 Bioaccumulation tests of MNPs in freshwater bivalves have primarily been conducted in Corbicula fluminea, 22,102 Anodonta cygnea, 111 and Dreissena polymorpha. 112,113 After exposure to AgNPs, most particles accumulated in the viscera (gills and digestive tract) of C. fluminea, while mantle, muscle, and foot tissue showed low accumulation potential.…”

“…109 As filter feeders, bivalves represent one of the most important pathways of MNPs into the human food chain. 35,110…”

“…A meta-analysis has been developed to study the toxicological TiO 2 NPs on marine bivalves. 34,35 Furthermore, due to the diversity of the MNPs, toxicity evaluation is challenging to access, and the limitation remains to test various MNPs' toxicity each time. To address these limitations, a toxicity mechanism-based approach, such as the adverse outcome pathway (AOP), is more practical than a substance-based approach.…”

“…A meta-analysis has been developed to study the toxicological TiO 2 NPs on marine bivalves. 34,35 Furthermore, due to the diversity of the MNPs, toxicity evaluation is challenging to access, and the limitation remains to test various MNPs' toxicity each time.…”

Immunotoxic effects of metal-based nanoparticles in fish and bivalves

“…Before some recent studies, there was no data on the mode of uptake or ingestion rates of the MNPs in bivalve species and thus the actual internal exposure concentration was not known (Canesi et al 2012). Most recent studies have reported that the concentration of the MNPs in the bivalve's bodies depends on the type of MNPs and properties of the ecosystems in which bivalves live, this can fluctuate roughly from 0 to 1000 mg/L (Li et al 2021;de Marchi et al 2019). After exposure to the MNPs, the particles cross the epithelium of digestive gland tubules of bivalves from where they are taken up via cell-surface lipid raft-associated domains, called caveola, or through endocytic pathways (Moore 2006).…”