Toxic effects of methamidophos on paraoxonase 1 activity and on rat kidney and liver and ameliorating effects of alpha‐tocopherol

Araoud, Manel; Neffeti, Fadoua; Khaled, Lamia; Najjar, Mohamed Fadhel; Kénani, Abderraouf; Houas, Zohra

doi:10.1002/tox.22095

Cited by 18 publications

(15 citation statements)

References 36 publications

(75 reference statements)

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“…Further supports to our discussion come from the work of Ahmad et al [47] and Araoud et al [48] who revealed that bendiocarp, carbofuran, …”

Section: Resultssupporting

confidence: 89%

Acute Poisoning among Farmers by Chlorpyrifos: Case Report from Gaza Strip

El‐Nahhal¹

2017

ODEM

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Spraying of organophosphorus insecticides (OPI) using high volume technique may result in poisoning cases among farmers or inhabitants in the spraying zone. This study reported a case among farmers in Gaza Strip, Palestine and discussed the follow up treatments. Results showed sever fasciculation of tongue and all muscle, pinpoint pupils not reacting to light, losing consciousness and disoriented, irritability, followed by diarrhea, vomiting, and severe inhibition of acetyl choline esterase (ACHE). Irritability and low level of ACHE activity were the unique syndromes of this case. Management of the poisoning with Atropine injection was not successful treatment to cure the case. Treatment with Toxogonin as intravenous injection resulted in relieved the irritability of the poisoned case and cure the patient at the end point. During the six weeks of follow up period, the case was severely poisoned in the 1 st week, moderate poisoned in the 2 nd week and slightly poisoned at the 3 rd week. A medical decision to release the patient was made after ACHE activity level reached 4750 U/L, which very close to the normal range. The farmers left the hospital after three weeks of medical treatments and follow up. It is recommended to use Toxogonin in the management of poisoned cases with OPI immediately on arrival of cases with losing consciousness.

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“…Further supports to our discussion come from the work of Ahmad et al [47] and Araoud et al [48] who revealed that bendiocarp, carbofuran, …”

Section: Resultssupporting

confidence: 89%

Acute Poisoning among Farmers by Chlorpyrifos: Case Report from Gaza Strip

El‐Nahhal¹

2017

ODEM

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“…Sublethal concentrations of methamidophos, phorate, and RPR-II seem to increase AcP and ALP in plasma and lower them in the liver tissue of animals (60,68,69). Similar findings have been reported for sub-chronic monocrotophos, methyl parathion, and dimethoate effects on ALP and AcP levels in plasma, but not in the liver, where they also increased (21,59).…”

Section: Biochemical Evidence Of Op Hepatotoxicitysupporting

confidence: 65%

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Karami‐Mohajeri

Ahmadipour

Rahimi

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism. Most studies show that antioxidants can attenuate oxidative stress and the consequent changes in liver function. However, few studies have examined the relationship between OP structures and the severity and mechanism of their action. We hope that future in vitro, in vivo, and clinical trials will answer the remaining questions about the mechanisms of OP hepatotoxicity and its management.

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“…Also, that the dosage and treatment duration Vitamin E varies across studies. Vitamin E has been used in a wide dose ranges from modest 100 IU/d[ 32 ] or 200 IU/d[ 33 34 ] to high doses such as 1200 IU/d[ 35 ] in various experiments. As antiepileptics are commonly weak oxidants, and their influence on oxidative stress have been commonly traced after long term intake of this agents, we believe that administration of a modest (400 IU/d) dose of Vitamin E could sufficiently compensate for their pro-oxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients

et al. 2016

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Background:Oxidative stress has been a frequent finding in epileptic patients receiving antiepileptic drugs (AEDs). In this study, the influence of Vitamin E on the antiseizure activity and redox state of patients treated with carbamazepine, sodium valproate, and levetiracetam has been investigated.Materials and Methods:This double-blind, placebo-controlled trial was carried out on 65 epileptic patients with chronic antiepileptic intake. The subjects received 400 IU/day of Vitamin E or placebo for 6 months. Seizure frequency, electroencephalogram (EEG), and redox state markers were measured monthly through the study.Results:Total antioxidant capacity, catalase and glutathione were significantly higher in Vitamin E received group compared with controls (P < 0.05) whereas malodialdehyde levels did not differ between two groups (P < 0.07). Vitamin E administration also caused a significant decrease in the frequency of seizures (P < 0.001) and improved EEG findings (P = 0.001). Of 32 patients in case group, the positive EEG decreased in 16 patients (50%) whereas among 33 patients in control group only 4 patients (12.1%) showed decreased positive EEG.Conclusion:The results of this preliminary study indicate that coadministration of antioxidant Vitamin E with AEDs improves seizure control and reduces oxidative stress.

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Toxic effects of methamidophos on paraoxonase 1 activity and on rat kidney and liver and ameliorating effects of alpha‐tocopherol

Cited by 18 publications

References 36 publications

Acute Poisoning among Farmers by Chlorpyrifos: Case Report from Gaza Strip

Acute Poisoning among Farmers by Chlorpyrifos: Case Report from Gaza Strip

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients

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