Toxic effects of fluoride on organisms

Zuo, Huancong; Chen, Liang; Kong, Ming; Qiu, Lipeng; Lu, Ping; Wu, Peng; Yang, Yanhua; Chen, Keping

doi:10.1016/j.lfs.2018.02.001

Cited by 207 publications

(82 citation statements)

References 44 publications

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“…Fluoride is a nonmetallic negatively-charged ion. It occurs naturally in the rocks, soil, and water of seas, rivers, and lakes [1]. The concentrations of fluoride in polluted seawaters generally range from 1.2 to 1.5 mg F/L [2].…”

Section: Introductionmentioning

confidence: 99%

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Ahmed

Sadek

Soliman

et al. 2020

Animals

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The potential antioxidant property of Moringa oleifera (MO) has been the recent focus of an increased number of studies. However few studies investigated its antioxidative ability against sodium fluoride-induced redox balance breakdown in Oreochromis niloticus. Thus, this study evaluates the effects of MO against the oxidative stress induced by sub-chronic exposure to sodium fluoride (NaF). A total of 264 fish (40 ± 3 g BW) were used to calculate the 96 hr-LC50 of NaF and perform the sub-chronic exposure study. 96 hr-LC50 of NaF was calculated as (61 mg/L). The 1/10 dose of the calculated 96 hr-LC50 (6.1 mg/L) was used to complete the sub chronic exposure for eight weeks. Fish were divided into four groups (n = 51; three replicates each); control, non-treated group; NaF group (exposed to NaF 6.1 mg/L); MO group (treated with 1% MO of diet); and NaF+MO (exposed to NaF 6.1 mg/L and treated with 1% MO of diet). The results revealed that the sub-chronic exposure to NaF (6.1 mg/L) was substantially increased malondialdehyde (MDA) and decrease the activities of superoxide dismutase (SOD), catalase (CAT), glutathione reduced (GSH), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) in the gills, liver, kidney, and muscle tissue in a time-dependent manner. In addition, a significant reduction in mRNA expression of GST in the liver was reported following NaF exposure. On the contrary, dietary supplementation of MO to NaF-exposed fish resulted in a significant reduction in MDA levels, and a significant elevation of SOD, CAT, GSH, GPx, and TAC activities in a time-dependent manner, in addition to significant elevation of GST mRNA expression in liver tissue. It could be concluded that a 1% MO (w/w) ration is a promising antioxidant plant that may successfully use to interfere with the oxidation processes induced by NaF in various tissues of Oreochromis niloticus.

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Section: Introductionmentioning

confidence: 99%

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Ahmed

Sadek

Soliman

et al. 2020

Animals

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“…Fluoride is an important nonmetal which is ubiquitous in the environment and widely used in the manufacture of teeth healthcare products and fluoridation of drinking water . Although fluoride at low concentrations is needed for teeth and bone growth, undue exposure to fluoride is well established to be associated with noxious impact on both animal and human health . Indeed, the World Health Organization indicated that fluoride above 1.0‐1.5 mg/L in drinking water is not safe…”

Section: Introductionmentioning

confidence: 99%

Fluoride and diethylnitrosamine coexposure enhances oxido‐inflammatory responses and caspase‐3 activation in liver and kidney of adult rats

Owumi

Aliyu‐Banjo

Danso

2019

J Biochem & Molecular Tox

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The present study investigated the impact of coexposure to fluoride and diethylnitrosamine (DEN) on hepatorenal function in adult rats. The animals were exposed to fluoride (15 mg/L in drinking water) and DEN (10 mg/kg) singly or coexposed to both compounds for 14 days. Results demonstrated that the fluoride or DEN mediated increase in hepatorenal toxicity was intensified in the coexposure group. Additionally, the decrease in antioxidant enzyme activities as well as the elevation in reactive oxygen and nitrogen species, and lipid peroxidation was markedly aggravated in rats coexposed to DEN and fluoride. Furthermore, the increase in levels of nitric oxide, tumor necrosis factor-α and interleukin-1β, myeloperoxidase and caspase-3 activities as well as histological lesions was more pronounced in the liver and kidney of rats coexposed to DEN and fluoride. Conclusively, coexposure to fluoride and DEN exacerbated hepatorenal damage via enhancement of oxido-inflammatory responses and caspase-3 activation in rats. K E Y W O R D S caspase-3, coexposure, diethylnitrosamine, fluoride, oxido-inflammation, rats J Biochem Mol Toxicol. 2019;33:e22327.wileyonlinelibrary.com/journal/jbt

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“…Apart from its major tooth protective property of arresting the demineralization of dental hard tissue and enhancing the remineralization process, fluoride can also affect bacterial growth and microbial metabolic activity by the inhibition of enolase and F-ATPase at high concentrations [10]. However, there is debate concerning the fluoride levels in drinking water because of fluorosis and other health risks [11,12]. Given all these facts, other anticaries agents should be adequately studied.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial peptide GH12 targetsStreptococcus mutansto arrest caries development in rats

Wang

Zeng

et al. 2018

Journal of Oral Microbiology

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Background:Targeting Streptococcus mutans, the principle cariogenic bacterium, could prove to be an effective means of preventing dental caries. A de novo designed antimicrobial peptide, GH12, has shown bactericidal effects on S. mutans and inhibitory effects on virulence and regulatory systems of S. mutans. However, the effects of GH12 on caries remain to be elucidated.Objectives: The objectives of this study were to evaluate the direct effects of GH12 on caries and numbers of S. mutansin vivo.Design: The Keyes score was evaluated in a rodent model and in vivo S. mutans was quantified by qPCR. To further interpret the in vivo anticaries efficacy, an in vitro biofilm model using short-term treatments with GH12 mimicked treatments in vivo was adopted. Results: In vivo data showed that GH12 at 8 mg/L reduced the incidence and severity of caries. Furthermore, GH12-treated animals had less S. mutans infection. In vitro data revealed that GH12 reduced the number of S. mutans within the biofilm, as well as reducing lactic acid and water-insoluble EPS synthesis of S. mutans biofilms. Afterwards, all rats showed no significant difference in weight gain, and no sign of harm to the mucosa, indicating that GH12 possessed good biocompatibility in vivo.Conclusion: Due to the combined inhibitory effects of GH12 on the biomass and cariogenic properties of S. mutans biofilms, the population of S. mutans in vivo was reduced, residual S. mutans biofilms were less acidic and compact, and thereby the onset and development of caries were arrested. Such findings collectively certified the clinical prospects for GH12. ARTICLE HISTORY

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Toxic effects of fluoride on organisms

Cited by 207 publications

References 44 publications

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Fluoride and diethylnitrosamine coexposure enhances oxido‐inflammatory responses and caspase‐3 activation in liver and kidney of adult rats

Antimicrobial peptide GH12 targetsStreptococcus mutansto arrest caries development in rats

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