Toxic effects of diazinon and its photodegradation products

Čolović, Mirjana B.; Krstić, Danijela; Petrović, Suzana; Leskovac, Andreja; Joksić, Gordana; Savić, Jasmina; Franko, Mladen; Trebše, Polonca; Vasić, Vesna

doi:10.1016/j.toxlet.2009.11.022

Cited by 93 publications

(54 citation statements)

References 43 publications

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“…The extent of water pollution by toxins depends on the distance between the water resource and the sprayed area, the amount of precipitation, soil permeability, soil type, and other factors (7). The degree to which people are adversely affected by the toxins depends on the quality of the chemicals, the length of time they are used, the duration of human exposure to them, the concentration of the pesticide, and the degree of its toxicity (8,9). Results of some research have shown that pesticide application causes human health complications, including abortion, mental retardation, defective fetuses, and potential carcinogenesis and mutation (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…According to reports from these organizations, the use of some pesticides has been banned and the use of others has been limited in some countries (10). Since the use of organochlorine insecticides has been banned, organophosphate pesticides are increasingly being used all over the world to control pests (1,8,9). However, organophosphate pesticides are relatively volatile and enter the human body through contract with the skin and through the respiratory system (13).…”

Section: Introductionmentioning

confidence: 99%

“…However, organophosphate pesticides are relatively volatile and enter the human body through contract with the skin and through the respiratory system (13). They suppress cholinesterase, overstimulate neurons, and cause neurological side effects (9,11,13,14). Diazinon is one organo-phosphorus insecticide used to control a broad spectrum of pests in agriculture and at home (15).…”

Section: Introductionmentioning

confidence: 99%

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Adsorption of diazinon from aqueous solutions onto an activated carbon sample produced in Iran

Akbarlou

Alipour

Heidari

et al. 2017

Environ Health Eng Manag

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Background: Considering the severe health and environmental hazards caused by the entry of diazinon toxin into water resources, its removal is very important. Given the high costs of imported adsorbents, this research attempted to evaluate, for the first time, the efficiency of Iranian activated carbon in removing diazinon from aqueous solutions. Methods: In this batch experimental study, the effects of contact time (5-90 minutes), adsorbent concentration (0.5-30 g/L), initial concentration of diazinon (5-50 mg/L), and pH (3-10) on the adsorption of diazinon onto the activated carbon were evaluated. Concentrations of diazinon were measured using a high pressure liquid chromatography (HPLC) instrument. The specific surface area of the adsorbent was determined by BET and BJH methods. The experimental adsorption data was analyzed using Langmuir and Freundlich isotherm models. Pseudo first-order and pseudo second-order kinetics models were employed to determine kinetics. Moreover, data was analyzed using SPSS version 19, and Pearson correlation and analysis of variance (ANOVA) tests were performed at a significance level of 0.05. Results: The optimum contact time, sorbent dose, and pH were 30 minutes, 10 g/L, and 5, respectively. The adsorbent could adsorb diazinon with a removal efficiency of 92.5% under optimum conditions (initial concentration: 20 mg/L). The experimental data was better described by the pseudo-second order kinetic and Langmuir isotherm. A maximum adsorption capacity of 71.4 mg/g was calculated by the Langmuir isotherm model. Conclusion: With respect to the high adsorption capacity of Iranian activated carbon, this sorbent can be considered an efficient adsorbent for the removal of diazinon from aqueous solutions. Keywords: Diazinon, Adsorption, Activated carbon, High pressure liquid chromatography Citation: Akbarlou Z, Alipour V, Heidari M, Dindarloo K. Adsorption of diazinon from aqueous solutions onto an activated carbon sample produced in Iran.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adsorption of diazinon from aqueous solutions onto an activated carbon sample produced in Iran

Akbarlou

Alipour

Heidari

et al. 2017

Environ Health Eng Manag

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“…Despite its low persistence in the environment, it is a nonspecific insecticide and highly toxic to animals and humans. Moreover, the toxicity of OPs is increased by its break-down products, which may be bioactivated within an organism or trough exposure to the sunlight 3,4 . Therefore, diazinon (DI) was selected as the toxic material for this study.…”

Section: Introductionmentioning

confidence: 99%

Akut Toksisite Sıçan Modelinde Diazinonun Neden Olduğu Akciğer, Karaciğer ve Böbrek Hasarı Üzerine Kafeik Asit Fenetil Ester, Elajik Asit, Sulforafan ve Kurkumin’in Etkileri

Alp¹,

Aytekin²,

Esen³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryThe aim of this study was to investigate the possible protective effects of caffeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphane (SFN) and curcumin (CUR) against the toxic effects of diazinon (DI). Sixty Sprague Dawley rats were randomly divided into 10 groups. Five groups were allocated as control groups comprising unmedicated control, CAPE, EA, SFN and CUR control groups. The remaining five groups were the study groups comprising DI, DI + CAPE, DI + EA, DI + SFN, and DI + CUR groups. The animals were sacrified 24 h after drug administrations. DI caused a decrease in acetyl cholinesterase (AChE) activity (P<0.05) and increases in γ-glutamyltransferase (GGT) and amylase activities. It also damaged the kidney, liver, and lung tissues. The negative effects of DI on these enzymes were confirmed histopathologically. Also, CAPE, EA, SFN and CUR reduced amylase and GGT activities and caused an increase in the AChE activities that were increased due to the toxic effects of DI. Thus, it was determined biochemically and histopathologically that these medication reduced the degenerative toxic effects created by DI in the lung, liver and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication.

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“…In cultured human lymphocytes diazinon (0.04 µg mL -1 ) induced a weak increase in the number of micronucleated cells (9). However, in another study of cultured human blood cells, it increased the frequency of micronuclei and inhibited cell proliferation (10). Contradictory findings obtained so far highlight the need to use different assays and different test materials for diazinon genotoxicity studies.…”

mentioning

confidence: 99%

Genotoxic effects of diazinon on human peripheral blood lymphocytes / Genotoksično djelovanje diazinona na limfocite ljudske periferne krvi

Gökalp

Kanev

Özdemir

2015

Archives of Industrial Hygiene and Toxicology

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The aim of this study was to evaluate the genetic damage in human peripheral blood lymphocytes following 24 and 48-hour exposure to a commercial diazinon formulation Basudin 60EM ® at concentrations between 0.01 and 40 µg mL -1 . For this purpose we used the micronucleus (MN), fluorescence in situ hybridization (FISH), and alkaline single cell gel electrophoresis (comet) assay. Diazinon significantly increased the frequency of micronucleated cells compared to control. Forty-eight-hour exposure increased this frequency even at lower concentrations (0.01-10 µg mL -1 ). The FISH results revealed aneugenic effects at 10 µg mL -1 . The comet assay also confirmed DNA damage at concentrations between 10 and 40 µg mL -1. Our findings have confirmed the genotoxic potential of diazinon and its cytotoxic effect on human lymphocytes. The increased DNA damage in our study raises concern about the current assessment of the health risk posed by this pesticide and calls for a high level of caution in agricultural and household use.

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Toxic effects of diazinon and its photodegradation products

Cited by 93 publications

References 43 publications

Adsorption of diazinon from aqueous solutions onto an activated carbon sample produced in Iran

Adsorption of diazinon from aqueous solutions onto an activated carbon sample produced in Iran

Akut Toksisite Sıçan Modelinde Diazinonun Neden Olduğu Akciğer, Karaciğer ve Böbrek Hasarı Üzerine Kafeik Asit Fenetil Ester, Elajik Asit, Sulforafan ve Kurkumin’in Etkileri

Genotoxic effects of diazinon on human peripheral blood lymphocytes / Genotoksično djelovanje diazinona na limfocite ljudske periferne krvi

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