Toxic effects of chlorpyrifos on antioxidant enzymes and target enzyme acetylcholinesterase interaction in mosquito fish, Gambusia affinis

Kavitha, P.; Rao, J. Venkateswara

doi:10.1016/j.etap.2008.03.010

Cited by 165 publications

(87 citation statements)

References 64 publications

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“…This exposure resulted in 70% inhibition of these enzymes. In another study of the same species, exposure to 297 μg CPY L −1 for 96 h resulted in 80% inhibition of brain-AChE (Kavitha and Rao 2008 ), but activity had recovered to control levels after 20 d in clean water. AChE activity in the brain of Nile tilapia, Oreochomis niloticus , exposed to 10 μg CPY L −1 for 24 h declined to 47% of control values but, after transfer to clean water, recovered to 55% after 7 d and 63% after 14 d (Chandrasekera and Pathiratne 2005 ).…”

Section: Toxicity Of Cpy and Temporality Of Exposuresmentioning

confidence: 94%

Risks to Aquatic Organisms from Use of Chlorpyrifos in the United States

Giddings¹,

Williams

Solomon

et al. 2014

Reviews of Environmental Contamination and Toxicology

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Section: Toxicity Of Cpy and Temporality Of Exposuresmentioning

confidence: 94%

Risks to Aquatic Organisms from Use of Chlorpyrifos in the United States

Giddings¹,

Williams

Solomon

et al. 2014

Reviews of Environmental Contamination and Toxicology

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“…Numerous environmental issues have arisen so far due to the excessive use of this chemical compound (3), as it, among other consequences, causes toxic effects in non-target aquatic organisms, especially fish (4). Fish are used to assess the health of aquatic environments and physiological changes occurring as a result of pollution and multiple studies have already established that chlorpyrifos has various detrimental effects on t h e m ( 5 -1 0 ) , s u c h a s n e u r o t o x i c i t y v i a acetylcholinesterase inhibition (11), biochemical and histopathological alterations (12, 13), oxidative stress (12, 14), genotoxicity (15), and olfactory and neurobehavioral injuries (16). It therefore poses a serious threat to aquatic organisms as well as to human health (17).…”

mentioning

confidence: 99%

In vivo changes in carbonic anhydrase activity and histopathology of gill and liver tissues after acute exposure to chlorpyrifos in rainbow trout

Topal¹,

Atamanalp²,

Oruç³

et al. 2014

Archives of Industrial Hygiene and Toxicology

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Chlorpyrifos is an organophosphate pesticide widely used in agriculture and aquaculture. This study investigated its effects on carbonic anhydrase (CA) enzyme activity and histopathology of rainbow trout gill and liver. The fish were exposed to 2.25 (25 % of 96 h LC 50 ), 4.5 (50 % of 96 h LC 50 ), and 6.75 µg L -1 (75 % of 96 h LC 50 ) of chlorpyrifos for 24, 48, 72, and 96 h. CA activity was measured in liver and gills and histopathological changes were examined by light microscopy. The most common liver changes at most of the chlorpyrifos concentrations were hyperaemia and degenerative changes. Gill tissues were characterised by lamellar hyperaemia, lamellar oedemas, clumping, cellular degeneration, hyperplasia, and lamellar atrophy. CA enzyme activity in the gills decreased at all concentrations at 48, 72, and 96 h after exposure to chlorpyrifos (p<0.05). Similarly, there was a time-dependent decrease in CA activity at all of the concentrations in liver tissues (p<0.05). The present study indicated that chlorpyrifos inhibits CA enzyme activity and causes histopathological damage in gill and liver tissues.

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“…"The 96 h LC 50 value for chlorpyrifos for juvenile and adult Oreochromis niloticus has been determined as 98.67 µg/L and 154.01 µg/L, respectively" [35]. For chlorpyrifos 96 h, LC 50 was reported as 0.176 ppm for Poecilia reticulata [36], 297 mg/L for Gambusia affinis [37], and 580 µg/L for Cyprinus carpio [38]. Acute static 96 h LC 50 for several fingerling freshwater fishes indicate a broad range of sensitivity to chlorpyrifos 18 µg/L for Salmo clerki, 7.1 µg/L for Salmo gairdneri, 98 µg/L for Salvenius namaycush, 280 µg/L for Ictalurus punctatus and 2.4 µg/L for Lepomis microchiras [39].…”

Section: Discussionmentioning

confidence: 99%