Toxic effects induced in neuromuscular tissues by work in hyperbaric helium/oxygen/carbon dioxide environments

Friess, S.L.; Durant, R.C.; Martin, Harold L.; Cowan, M.J.

doi:10.1016/0041-008x(70)90202-4

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…The ability of man to explore the ocean depths remains limited primarily because of such neurophysiological effects as narcosis and high pressure nervous syndrome (HPNS) (Hunter and Bennett, 1974;MacDonald, 1975;Zimmerman and Zimmerman, 1976). For this reason, a great deal of research is now directed at the development of diving gas mixtures and drug treatment schedules which might extend the present limits of manned dives (Friess et al, 1970;Hunter and Bennett, 1974;Beaver et al, 1977). While such studies are of great importance for their immediate practical application, the eventual extension of manned diving limits beyond 31 atm requires a better definition of the biomolecular causes of narcosis and, especially, HPNS.…”

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“…Studies concerned with the effects of pressure on animal neural tissues date back nearly a century to the pioneering work of Regnard (1891). Since these early studies a number of investigators have used a variety of animal tissues or isolated nerve prepara-I167 tions for pressure investigations including, for example, rat phrenic nerve diaphragm (Friess et al, 1970; Kendig and Cohen, 1976), isolated frog sciatic nerve (Ebbecke and Schaeffer, 1935; Grundfest and Cattell, 1935), and frog cardiac muscle (Murakami, 1970). More recently, pressure effects on neural processes at synapses and receptors have been studied using squid axon (Henderson et al, 1977) and isolated rabbit duodenum (Akers and MacCarter, 1973; Akers and Carlson, 1976).…”

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Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue¹

Taylor¹,

Robertson²

1980

Journal of Neurochemistry

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En viron nil> n ttr l Bioscieric'cJ s Lkp(r rtm en t , Nci Y N I Medicd Rcserr rc h In stiticte , Nti tion ti l N N val Mr dictr I Ccn t er , Brt/wstlrr, Mtiryliind 20014, U.S.A .Abstract: The effects of hyperbaric pressure in helium-oxygen atmospheres on a proteoglycolipid, isolated from rat gastrocnemius tissue, with binding specificity for cholinergic ligands have been studied at six pressure levels in the ranges of 14.7 to 400 psi (1-27 atm). The binding of acetylcholine, abungarotoxin, tubocurarine, decamethonium, and nicotine t o the proteoglycolipid decreased with increasing pressure, the greatest binding losses occurring in the 14.7-100 psi range. The loss of [l'C]acetylcholine and 1251-labeled a-bungarotoxin binding to the proteoglycolipid with increasing pressure was augmented in the presence of cholinergic antagonists such as nonradioactive a-bungarotoxin, tubocurarine, and decamethonium. T h e presence of hexamethonium, a ganglionic cholinergic antagonist, in the reaction mixtures appeared to prevent loss of acetylcholine and a-bungarotoxin binding with increasing pressure. Saturation of the proteoglycolipid with acetylcholine at each pressure level indicated that the conformation of the isolated macromolecule may be distorted with increasing pressure, resulting in alterations to specific ligand-binding sites. The significance of these results is discussed in relation to the effects of pressure on in ,.ir*o neural processes.

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Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue¹

Taylor¹,

Robertson²

1980

Journal of Neurochemistry

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Shilling¹,

Werts²

1973

Underwater Medicine and Related Sciences

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Assessing the life support systems of the Ben Franklin submarine. In: Proceedings of the design engineering conference and show of the American Society of Mechanical Engineers, Chicago, May 1970, Paper 70-DE-60, 8p.With a successful completion of the Gulf Stream Dnft Mission, the Ben Franklin has more than proven itself. During this miSSion, a six-man crew was sustained for a little more than 30 days by a system that was quite umque In many respects. The system: (1) relied on natural convection for mmosphere control; (2) consumed essentially no electrical energy; (3) cost under $45,000 including expendables; (4) could have performed for 60 days with minor modificatIOns. (Author's abstract) (Aerosp. Med. BIOI.

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Study on mammal (rat) of the neuro-muscular synapse function under hyperbaric conditions (11 ata): Effects of the curarization

Barthelemy¹,

Belaud²

1982

Europ. J. Appl. Physiol.

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Under hyperbaric conditions (11 ata) obtained with normoxic O2-N2 mixtures spontaneous EMG activity disappears, as do reactions to noise, but this phenomenon is reversible after the substitution of Helium for Nitrogen in the mixture. Analysis of EMG responses to sciatic nerve excitation has revealed no difference between the EMG tracings recorded under normobaric pressure and those obtained under hyperbaric conditions (O2-N2 or O2-He, 11 ata), and hyperbaric conditions do not seem to interfere with neuro-muscular synaptic transmission. Furthermore, the effect of Pavulon (an antidepolarising, acetyl-cholino-competitive curare-mimetic drug) is similar under normal and hyperbaric conditions: hyperbaria change neither the onset of neuro-muscular blockage nor its intensity or duration. The absence of a specific effect on synapse function of a change in the diluting gas from nitrogen to helium suggests that there was no change in post-synaptic receptor function. This result is not in accordance with the hypothesis that inert gas pressures of less than 10 ata modify molecular structures particularly at the neuro-muscular synapse level.

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Toxic effects induced in neuromuscular tissues by work in hyperbaric helium/oxygen/carbon dioxide environments

Cited by 12 publications

References 9 publications

Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue¹

Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue¹

Abstracts

Study on mammal (rat) of the neuro-muscular synapse function under hyperbaric conditions (11 ata): Effects of the curarization

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Toxic effects induced in neuromuscular tissues by work in hyperbaric helium/oxygen/carbon dioxide environments

Cited by 12 publications

References 9 publications

Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue1

Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue1

Abstracts

Study on mammal (rat) of the neuro-muscular synapse function under hyperbaric conditions (11 ata): Effects of the curarization

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Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue¹

Effects of Normo‐ and Hyperbaric Pressure on an Acetylcholine‐Binding Proteoglycolipid from Rat Gastrocnemius Tissue¹