Toxic Effects Induced by Diuron and Its Metabolites in Caenorhabditis elegans

Lima, Thania Rios Rossi; Martins, Airton C.; Pereira, Lílian Cristina; Aschner, Michael

doi:10.1007/s12640-022-00596-2

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…Notably, an increase in GSH content after 1 h of exposure to diuron in zebrafish larvae at concentrations of 2, 5, and 10 mg L −1 has been documented [70]. Similarly, exposure to 500 µM of diuron significantly elevated GSH levels in the nematode Caenorhabditis elegans [71]. These findings underscore diuron's robust impact as a trigger of oxidative stress at the cellular level, with GSH playing a pivotal role in furnishing primary protection against the accumulation of ROS.…”

Section: Discussionmentioning

confidence: 78%

Acute and Chronic Effects of the Antifouling Booster Biocide Diuron on the Harpacticoid Copepod Tigriopus japonicus Revealed through Multi-Biomarker Determination

Yun,

Kim,

Kim

et al. 2023

JMSE

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Diuron, an additive biocide in antifouling paints, is widely employed to curtail the attachment of organisms on submerged surfaces in aquatic structures. Despite the detection of diuron in aquatic ecosystems, information regarding its acute and chronic impacts on aquatic invertebrates, particularly planktonic crustaceans, remains limited. In this study, we analyzed the acute (24 h) and chronic (12 days exposure across three generations) effects of different concentrations of diuron (1/10 of the no observed effect concentration (NOEC), the NOEC, and 1/10 of the lethal concentration 50% (LC50), derived from the 24 h acute toxicity value of 1152 μg L−1) on the harpacticoid copepod Tigriopus japonicus. The acute exposure experiment indicated that the 1/10 LC50 value of diuron significantly reduced the copepod’s feeding rate and acetylcholinesterase activity. In response to the 1/10 LC50 value, the intracellular reactive oxygen species were elevated alongside increased malondialdehyde levels, while the glutathione content was depleted. The enzymatic activities of glutathione S-transferase, catalase, and superoxide dismutase were significantly enhanced by the 1/10 LC50 value, suggesting a proactive role of the antioxidant defense system against oxidative stress. Conversely, the activities of glutathione peroxidase and glutathione reductase enzymes were increased at the NOEC value, while their values were reduced by the 1/10 LC50 value. Chronic exposure to 1/10 NOEC and NOEC values revealed the adverse multigenerational effects of diuron. The second generation exhibited the most sensitivity to diuron, with the NOEC value notably reducing survival rate, body length, nauplius-to-adult development, neonates per brood count, and extending the reproduction period. Taken together, our findings underscore that even sublethal diuron levels can adversely impact copepod populations across generations through intergenerational toxicity.

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Section: Discussionmentioning

confidence: 78%

Acute and Chronic Effects of the Antifouling Booster Biocide Diuron on the Harpacticoid Copepod Tigriopus japonicus Revealed through Multi-Biomarker Determination

Yun,

Kim,

Kim

et al. 2023

JMSE

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“…A pesar de que los cnidarios no presentan un sistema nervioso complejo, sí se ha relacionado la actividad colinesterasa en estos organismos con la transmisión nerviosa (Flores et al, 2020), sugiriendo que la toxicidad de los organofosforados puede seguir ese mismo mecanismo. En el caso del diuron, tampoco es claro el mecanismo de toxicidad para los cnidarios, pero en otros invertebrados se han observado señales de estrés oxidativo, daño mitocondrial y neurotoxicidad relacionados con la exposición a la sustancia y sus metabolitos (Lima et al, 2022). Una combinación de esos mecanismos descritos podría explicar el aumento de la toxicidad de la mezcla con respecto a las partes, si bien es necesaria más investigación para el caso específico de las hidras.…”

Section: Howe Et Al (2017) También Mencionan Que Al Exponer a Diuron ...unclassified

Sensibilidad de Hydra attenuata e Hydra viridis a los plaguicidas diuron y etoprofos, Costa Rica

Jones,

Ugalde,

Jiménez

et al. 2023

Uniciencia

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[Objetivo] El objetivo fue determinar cuál de las dos especies de hidras (Hydra attenuata o Hydra viridis) resultaba más sensible a dos plaguicidas, para luego usarla como parte de la batería de organismos de prueba del Laboratorio de Estudios Ecotoxicológicos (ECOTOX). [Metodología] Para esto se utilizaron diluciones de dos de los plaguicidas más comúnmente usados en el cultivo de piña en Costa Rica y detectados en muestras de agua: el herbicida diuron y el insecticida etoprofos. Se realizaron bioensayos de toxicidad con cada una de estas sustancias y con una mezcla de estas. Se registró el estado morfológico de las hidras. Además, se evaluaron la concentración de efecto medio (EC50), la concentración letal media (LC50), y las interacciones de toxicidad según tres posibilidades: antagónica, aditiva o sinérgica. [Resultados] La H. attenuata fue la especie más sensible a ambos plaguicidas, con LC50s de 16,84 mg/L y 103,01 mg/L; y EC50s de 4,24 mg/L y 23,74 mg/L para diuron y etoprofos, respectivamente. Mientras tanto la H. viridis tuvo LC50s de 36,94 mg/L y 103,01 mg/L, con EC50s de 13,64 mg/L y 53,12 mg/L, también para diuron y etoprofos, respectivamente. La exposición a la mezcla de plaguicidas solo causó mortalidad a la H. viridis y tuvo efecto sinérgico en ambas especies. [Conclusiones] Estos resultados sugieren que la H. attenuata es la especie más apropiada para la evaluación de efectos de plaguicidas, pero se deben realizar más estudios sobre las interacciones de los contaminantes en mezclas, porque estas pueden modificar su toxicidad para diferentes especies.

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Critical perspective on the elimination of emerging contaminants from industrial wastewater via microbial electrochemical technologies

Sikarwar,

Bashir,

Sharma

et al. 2024

CLEAN Soil Air Water

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Industrial water pollution originating from various industries like textile, dairy, oil, and petrochemical industries, etc. is a huge concern globally and has led to devastating effects on the environment due to the release of refractory emerging contaminants (ECs). These ECs of concern have attracted wide devotion from the scientific community due to their recalcitrant nature and disastrous effects on plants, aquatic life forms, and humans. In this regard, conventional wastewater treatment technologies such as coagulation, flocculation, membrane technologies, electrocoagulation, and other biological technologies like sequencing batch reactor, anaerobic up‐flow sludge blanket reactor, etc., are inefficient in removing ECs from the industrial effluent, while conventional advanced oxidation processes incur high cost due to the extensive requirement of energy for the degradation of ECs. To overcome this issue, microbial electrochemical technologies (METs) can be employed. For instance, METs have shown promising results in the degradation of various ECs, such as microbial fuel cells, which have shown nearly 92% to 98% removal of sulfamethoxazole with simultaneous power recovery. Alizarin yellow R, nitrobenzene, and Congo red were degraded by microbial electrolysis cells with removal efficiency in the range of 88% to 98%, demonstrating their superiority in the elimination of trace contaminants. Similarly, almost 100% mineralization of pyraclostrobin was noticed for the bio‐electro‐Fenton process, showing the elevated potential of these neoteric technologies for the remediation of recalcitrant pollutants. Thus, the current review article aims to critically analyze the intervention of METs for the elimination of ECs from industrial wastewater.

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Toxic Effects Induced by Diuron and Its Metabolites in Caenorhabditis elegans

Cited by 6 publications

References 43 publications

Acute and Chronic Effects of the Antifouling Booster Biocide Diuron on the Harpacticoid Copepod Tigriopus japonicus Revealed through Multi-Biomarker Determination

Acute and Chronic Effects of the Antifouling Booster Biocide Diuron on the Harpacticoid Copepod Tigriopus japonicus Revealed through Multi-Biomarker Determination

Sensibilidad de Hydra attenuata e Hydra viridis a los plaguicidas diuron y etoprofos, Costa Rica

Critical perspective on the elimination of emerging contaminants from industrial wastewater via microbial electrochemical technologies

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