Toxic effects in fish and the mutagenic capacity of water from the Sava River in Yugoslavia

Kurelec, Branko; Protić, Miroslava; Britvić, Smiljana; Kezić, N.; Rijavec, M.; Ζahn, Rudolf K.

doi:10.1007/bf01622073

Cited by 36 publications

(26 citation statements)

References 10 publications

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“…Controversial data is available on the effect of ANF on AHH activity. In some studies, ANF is reported to inhibit activity in microsomes from induced fish, but to have no effect or enhance activity in microsomes from control fish (Kurelec et al, 1981;Bend et al, 1977;Foureman et al, 1983); while others have found that ANF inhibits AHH activity in microsomes from both control and induced fish (Elcombe & Lech, 1979;Schwen & Mannering, 1982;Stegeman et al, 1981). Further investigations are therefore necessary before inhibition of AHH activity by ANF is accepted as an indication of stress caused by pollutants.…”

Section: Mummichog (Fundulus Heteroclitus)mentioning

confidence: 99%

Variation in hepatic aryl hydrocarbon hydroxylase activity in flounder,Platichthys flesus: A baseline study

Tarlebø

Solbakken

Palmork

1985

Helgolander Meeresunters

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This investigation is concerned with the natural variations in aryl hydrocarbon hydroxylase (AHH) activity of flounder (P1atichthys flesus L.) throughout the year. A general trend towards higher activity in males was observed. It became significant during gonadal maturation, a period during which the activity in females was inhibited. Addition of a-naphthoflavone inhibited AHH activity except in females with maturing gonads. Enzyme activity measured at the optimal temperature for incubation showed highest activity during spring followed by a significant decrease during summer. Activity increased again during autumn, followed by a second decrease in the winter season. When activity was calculated based on ambient water temperature at time of sampling, smaller fluctuations between different seasons were observed; the only significant variation was high activity in June. The results obtained indicate that AHH activity is affected by both exogenous and endogenous factors, which should be taken into consideration if AHH activity is used as a biological indicator of marine pollution effects.

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Section: Mummichog (Fundulus Heteroclitus)mentioning

confidence: 99%

Variation in hepatic aryl hydrocarbon hydroxylase activity in flounder,Platichthys flesus: A baseline study

Tarlebø

Solbakken

Palmork

1985

Helgolander Meeresunters

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“…Malins et al 1987. Although these particular studies have implicated pollutants as the etiological agents of neoplasia in fish, other workers have refuted this association (Hard et al 1979, Kurelec et al 1981.…”

Section: Introductionmentioning

confidence: 99%

Epizootic papillomas in Prown bullheads Ictalurus nebulosus from Silver Stream reservoir, New York

Bowser¹,

Wolfe²,

Reimer³

et al. 1991

Dis. Aquat. Org.

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ABSTRACT. Fish from Silver Stream reservoir in Newburgh, New York (USA) were examined in 1985 and 1986 following reports by fishermen who had found a high prevalence of skin lesions in brown bullheads Ictalurus nebulosus caught in the reservoir Oral and skin papillomas were found in 43.2 % and 60.0 O/o of the brown bullheads from these respective samplings, whereas no papillomas were found in yellow bullheads I. natalis. No viral particles could be idenuied by electron microscopy in the lesions nor were cytopathic effects observed in primary cell cultures of tumor cells or from coculti\ration of these cells with an established brown bullhead cell line. Extracts of the sediment from the reservoir contained known promutagens but the concentrations of these compounds were low and similar to those found at reference sites considered to be non-contaminated. Nevertheless a positive response in the Ames assay of the extracts of the sediment was recorded. Elevated levels of chromium, copper, manganese, lead and vanadium were found in the sediments and copper, manganese, nickel, strontium and lead were elevated in the water. The pH of the interstitial water was 4.5. It is unlikely that any of these parameters was the sole causative factor in the etiology of the papillomas.

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“…Two studies in particular by Kurelec et al (1981) and Slooff (1983), were discussed at some length by Mix (1986), who put them into a category of papers in which 'the high quality of data provided did not support the pollution-neoplasm postulate'. Two studies in particular by Kurelec et al (1981) and Slooff (1983), were discussed at some length by Mix (1986), who put them into a category of papers in which 'the high quality of data provided did not support the pollution-neoplasm postulate'.…”

Section: Lack Of Tumors In Contaminated Systemsmentioning

confidence: 99%

“…. However, of the seven locations from which hexane extracted Sava River water was tested for mutagenicity by Kurelec et al (1981), only one was highly mutagenic, and the water from the other locations was 'either not mutagenic or only 141 slightly so', suggesting that even portions of the Sava River considered polluted might not have contained elevated levels of genotoxins. despite evidence that the river water contained mutagens/carcinogens, and that fish were highly induced (Kezic et aL, 1983) .…”

Section: Lack Of Tumors In Contaminated Systemsmentioning

confidence: 99%

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The use of tumors in wild populations of fish to assess ecosystem health

Baumann

1992

Journal of Aquatic Ecosystem Health

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Evidence has linked toxicants in aquatic systems with cancer in fish and population level effects on species.Thus some types of tumors may be useful monitors of ecosystem health, at least as affected by genotoxins and promoters. However, tumors caused by purely genetic mechanisms or by virus would not be good indicators. Only neoplasms which have chemicals as a portion of their etiology (either as initiators or promoters) would be useful in assessing ecosystem health. Lesions which may fit these criteria include liver neoplasms (both biliary and hepatic) and skin lesions in a variety of primarily benthic fishes, and neural lesions in various drum species and in butterfly fish species. Two studies purporting to demonstrate a lack of tumors in fish from polluted areas have been reexamined and found either to have insufficient data on vulnerable species or to actually support a tumor-pollution linkage. Thus certain lesions in vulnerable species or species groups may serve as a mechanism to assess one facet of ecosystem health.

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Toxic effects in fish and the mutagenic capacity of water from the Sava River in Yugoslavia

Cited by 36 publications

References 10 publications

Variation in hepatic aryl hydrocarbon hydroxylase activity in flounder,Platichthys flesus: A baseline study

Variation in hepatic aryl hydrocarbon hydroxylase activity in flounder,Platichthys flesus: A baseline study

Epizootic papillomas in Prown bullheads Ictalurus nebulosus from Silver Stream reservoir, New York

The use of tumors in wild populations of fish to assess ecosystem health

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