Toxic Effects and Mechanisms of Silver and Zinc Oxide Nanoparticles on Zebrafish Embryos in Aquatic Ecosystems

Lee, Yen‐Ling; Shih, Yung-Sheng; Chen, Zi-Yu; Cheng, Fong‐Yu; Lu, Jingyu; Wu, Yuan-Hua; Wang, Ying Jan

doi:10.3390/nano12040717

Cited by 28 publications

(13 citation statements)

References 49 publications

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“…Due to well-established antimicrobial properties, Ag NPs are widely used in many consumer products, such as toothpaste, shampoos, washing powders, kitchen utensils, toys, filters and deodorants [ 59 , 60 ]. It is very important to evaluate the potential toxicity for safe and effective use as applications of Ag NPs are rapidly expanding.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

et al. 2022

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The development of smart, efficient and multifunctional material systems for diseases treatment are imperative to meet current and future health challenges. Nanomaterials with theranostic properties have offered a cost effective and efficient solution for disease treatment, particularly, metal/oxide based nanotheranostic systems already offering therapeutic and imaging capabilities for cancer treatment. Nanoparticles can selectively generate/scavenge ROS through intrinsic or external stimuli to augment/diminish oxidative stress. An efficient treatment requires higher oxidative stress/toxicity in malignant disease, with a minimal level in surrounding normal cells. The size, shape and surface properties of nanoparticles are critical parameters for achieving a theranostic function in the microenvironment. In the last decade, different strategies for the synthesis of biocompatible theranostic nanostructures have been introduced. The exhibition of therapeutics properties such as selective reactive oxygen species (ROS) scavenging, hyperthermia, antibacterial, antiviral, and imaging capabilities such as MRI, CT and fluorescence activity have been reported in a variety of developed nanosystems to combat cancer, neurodegenerative and emerging infectious diseases. In this review article, theranostic in vitro behaviour in relation to the size, shape and synthesis methods of widely researched and developed nanosystems (Au, Ag, MnOx, iron oxide, maghemite quantum flakes, La2O3−x, TaOx, cerium nanodots, ITO, MgO1−x) are presented. In particular, ROS-based properties of the nanostructures in the microenvironment for cancer therapy are discussed. The provided overview of the biological behaviour of reported metal-based nanostructures will help to conceptualise novel designs and synthesis strategies for the development of advanced nanotheranostic systems.

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Section: Silver Nanoparticlesmentioning

confidence: 99%

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

et al. 2022

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“…In particular, silver nanoparticles have been extensively studied [11][12][13][14][15] for their biocidal (bactericidal) action, being known and accepted three mechanisms of action on cells (bacteria):…”

Section: Introductionmentioning

confidence: 99%

“…Most of the problems of the known means of administration are related to the unpleasant appearance, irritation of the body surfaces generated by the matrix, rapid loss by friction, reduced persistence time and the need for short-term administration [14,15,23,26].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

et al. 2022

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The bio-medical benefits of silver ions and 10–undecenoic acid in various chemical-pharmaceutical preparations are indisputable, thus justifying numerous research studies on delayed and/or controlled release. This paper presents the effect of the polymer matrix in the simultaneous release of silver ions and 10–undecenoic acid in an aqueous medium of controlled pH and ionic strength. The study took into consideration polymeric matrices consisting of cellulose acetate (CA) and polysulfone (PSf), which were impregnated with oxide nanoparticles containing silver and 10–undecenoic acid. The studied oxide nanoparticles are nanoparticles of iron and silver oxides obtained by an accessible electrochemical method. The obtained results show that silver can be released, simultaneously with 10–undecenoic acid, from an impregnated polymeric membrane, at concentrations that ensure the biocidal and fungicidal capacity. Concentrations of active substances can be controlled by choosing the polymer matrix or, in some cases, by changing the pH of the target medium. In the studied case, higher concentrations of silver ions are released from the polysulfone matrix, while higher concentrations of 10–undecenoic acid are released from the cellulose acetate matrix. The results of the study show that a correlation can be established between the two released target substances, which is dependent on the solubility of the organic compound in the aqueous medium and the interaction of this compound with the silver ions. The ability of 10–undecenoic acid to interact with the silver ion, both through the carboxyl and alkene groups, contributes to the increase in the content of the silver ions transported in the aqueous medium.

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“…Effluents from manufacturing, consumer utilization, and disposal of ZnONPs increase their release into aquatic systems and eventually increase human exposure to ZnONPs [ 3 , 4 ]. Recent studies have investigated the toxicity effect of ZnONPs [ 5 , 6 ]. Although zinc is a critically important trace element for several biological functions and is known to be relatively harmless, rapid ionization can subsequently occur in cells that are in a weak acidic state [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive and Real-Time Detection of Zinc Oxide Nanoparticles Using Quartz Crystal Microbalance via DNA Induced Conjugation

Park

You

et al. 2022

Materials

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With the development of nanotechnology, nanomaterials have been widely used in the development of commercial products. In particular, zinc oxide nanoparticles (ZnONPs) have been of great interest due to their extraordinary properties, such as semiconductive, piezoelectric, and absorbance properties in UVA and UVB (280–400 nm) spectra. However, recent studies have investigated the toxicity of these ZnONPs; therefore, a ZnONP screening tool is required for human health and environmental problems. In this study, we propose a detection method for ZnONPs using quartz crystal microbalance (QCM) and DNA. The detection method was based on the resonance frequency shift of the QCM. In detail, two different complementary DNA strands were used to conjugate ZnONPs, which were subjected to mass amplification. One of these DNA strands was designed to hybridize to a probe DNA immobilized on the QCM electrode. By introducing the ZnONP conjugation, we were able to detect ZnONPs with a detection limit of 100 ng/mL in both distilled water and a real sample of drinking water, which is 3 orders less than the reported critical harmful concentration of ZnONPs. A phosphate terminal group, which selectively interacts with a zinc oxide compound, was also attached at one end of a DNA linker and was attributed to the selective detection of ZnONPs. As a result, better selective detection of ZnONPs was achieved compared to gold and silicon nanoparticles. This work demonstrated the potential of our proposed method as a ZnONP screening tool in real environmental water systems.

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Toxic Effects and Mechanisms of Silver and Zinc Oxide Nanoparticles on Zebrafish Embryos in Aquatic Ecosystems

Cited by 28 publications

References 49 publications

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

Highly Sensitive and Real-Time Detection of Zinc Oxide Nanoparticles Using Quartz Crystal Microbalance via DNA Induced Conjugation

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