Toxic Effect of Aflatoxin B1 on Heart, Lung, and Testis of Male Albino Rats: Histopathology Study

Abstract

The current study was carried out to investigate the toxic effects of aflatoxin B1 exposure on heart, lung, and testis of male Albino rats. Twelve healthy male Albino rats were used in the current study. They were divided equally into 2 groups (control and treated groups). The treated group was given aflatoxin B1 orally by a gastric tube at concentration 0.5 mg per kg of body weight for 7 day. The control group was given distilled water alone. At the end of experiment (1 week), the rats were killed under ether anesthesia and the internal organs(heart, lung, and testis) were collected immediately for histological examination. The histopathology examination in heart revealed that there is oedema between myocardial. In lung, there is a large number of inflammatory cells and dilated the alveolar sac with exudates. The testis revealed the excessive vacuolated cells and suppression spermatogenesis. In conclusion, oral dose of aflatoxin B1 exposure could induce a deleterious effect on the histological structure of the heart, lung, and testis of male Albino rats. High level of attention must be taken to prevent the possible contamination of our food with aflatoxin B1.

Protective and Therapeutic Effects of Lactic Acid Bacteria against Aflatoxin B1 Toxicity to Rat Organs

“…The testes of the AF group demonstrated vacuolated STs with completely lost spermatogenic cells, widened interstitial space, germinal epithelium detachment from the basement membrane, and lower spermatogenic cell numbers. Kudayer et al [ 57 ] revealed that AFB1 administration to rats for seven days resulted in excessively vacuolated testicular cells with suppressed spermatogenesis. These results are in line with previous studies, which have established AF’s toxicity to the reproductive system [ 58 , 59 ].…”

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“…Among the toxins, AB1 has long-term adverse effects on the liver, kidneys, brain, and especially the testes. This toxin can cause testicular inflammation resulting in impaired sperm production [27]. Various remedies have been proposed for the treatment of orchitis, but preference has been given to the use of biological constituents rather than chemical synthetic materials.…”

Blood-Derived Exosomes With Anti-Inflammatory Properties As A New Minimally Invasive Intratesticular Therapy For Aflatoxin B1-Associated Chronic Testopathy

“…Among the toxins, AB1 has long-term adverse effects on the liver, kidneys, brain, and especially the testes. This toxin can cause testicular inflammation resulting in impaired sperm production [27]. Various remedies have been proposed for the treatment of orchitis, but preference has been given to the use of biological constituents rather than chemical synthetic materials.…”