Toxic cytological alteration and mitochondrial dysfunction in PC12 cells induced by 1-octyl-3-methylimidazolium chloride

Li, Xiaoyü; Jing, Changqin; Zang, Xiayan; Yang, Shuai; Wang, Jianji

doi:10.1016/j.tiv.2012.07.006

Cited by 44 publications

(46 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, MPT induction is a catastrophic event that can lead to apoptosis (Eaton and Klaassen, 2001). According to previous studies, many types of chemicals such as methylmercury, silver nanoparticles, and ionic liquids can induce MPT and lead to mitochondrial dysfunction (Polunas et al, 2011;Teodoro et al, 2011;Li et al, 2012b). Our results reveal that resveratrol may promote the opening of MPTPs and induce MPT in the treated QGY-7701 cells, causing mitochondrial depolarization and ATP depletion.…”

Section: Discussionsupporting

confidence: 68%

“…The inner membrane is the site of oxidative phosphorylation, which produces ATP. Mitochondrial permeability transition (MPT) can disrupt the permeability barrier of the inner membrane, thus dissipating the membrane potential and pH gradient that together drive ATP synthesis, causing the impairment of mitochondrial function (Li et al, 2012b). Thus, MPT induction is a catastrophic event that can lead to apoptosis (Eaton and Klaassen, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…FDA-staining is often used to determine the alteration of plasma membrane permeability (Zhou et al, 2010;Li et al, 2012b). Briefly, the QGY-7701 cells were cultured on 6-well plates (1 x 10 6 cells per well) with 0, 6, 12, and 24 µM resveratrol for 24 h, and then cells were collected and washed twice with PBS.…”

Section: Alteration Of Plasma Membrane Permeability Determinationmentioning

confidence: 99%

See 2 more Smart Citations

Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells

Chen

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dosedependent manner. Resveratrol exposure also induced an increase in Caspase-3 activity and a decrease in Bcl-2, which caused an increase in membrane permeability, and the opening of mitochondrial permeability transition pores and mitochondrial depolarization. Cellular ATP is thus exhausted, and apoptosis is induced via the change in mitochondrial membrane permeability and mitochondrial dysfunction.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Alteration Of Plasma Membrane Permeability Determinationmentioning

confidence: 99%

See 1 more Smart Citation

Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells

Chen

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Aer staining, the cells were washed twice with PBS and incubated for another 10 min at 37 C before uorescence-intensity detection. 18 …”

Section: Cell Viability Assaymentioning

confidence: 99%

“…4B). 18 The result indicated that torulene had a stronger effect on the induction of apoptosis in LNCaP cells than PC-3 cells.…”

mentioning

confidence: 96%

Anti-cancer effects of torulene, isolated from Sporidiobolus pararoseus, on human prostate cancer LNCaP and PC-3 cells via a mitochondrial signal pathway and the down-regulation of AR expression

Guo

Cheng

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

In this work, we investigated the anti-cancer effect of torulene, a carotenoid from Sporidiobolus pararoseus, on androgen-sensitive/insensitive prostate cancer cells lines and found that torulene induced apoptosis at moderate cytotoxic concentrations in both cell lines. It was further demonstrated that the apoptosis induced by torulene was due to the modulation of Bcl-2 family members, resulting in decrease of mitochondria membrane potential and increase of the intracellular calcium concentration. Furthermore, its growth-inhibitory effects on LNCaP cells also showed a relationship with the down-regulation of AR and PSA expression. Therefore, the results indicated that a mitochondria-mediated pathway and the expression of AR might play essential roles in the apoptosis process induced by torulene in prostate cancer cells.

show abstract

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

Tai

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

Transdermal drug delivery is a promising strategy characterized by minor fluctuations in blood concentrations, few adverse effects, convenience, and excellent patient compliance, especially for biomacromolecules. Conversely, traditional delivery methods are limited by their poor penetration abilities and complex preparation and application techniques. However, some inherent properties of biomacromolecules, such as large sizes, complex structure, and poor stability, can affect their ability to overcome skin barriers and reach deeper layers. Ionic liquids (ILs) are organic salts composed of asymmetric cations and anions in liquid form below 100 °C. ILs provide excellent protection for biomacromolecules and can facilitate their passage through the stratum corneum to cells for therapeutic effects. Therefore, they represent one of the most promising approaches to promoting transdermal penetration. Here, the barriers to effective transdermal delivery, including skin properties and the stability and biocompatibility of IL‐based biomacromolecule formulations, are highlighted and the current status of IL‐based biomacromolecule formulations are focused on, the tremendous advantages of using ILs based on current challenges in transdermal drug delivery are discussed, and light is shed on several ILs frequently used in the delivery of biomacromolecules.

show abstract

Toxic cytological alteration and mitochondrial dysfunction in PC12 cells induced by 1-octyl-3-methylimidazolium chloride

Cited by 44 publications

References 34 publications

Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells

Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells

Anti-cancer effects of torulene, isolated from Sporidiobolus pararoseus, on human prostate cancer LNCaP and PC-3 cells via a mitochondrial signal pathway and the down-regulation of AR expression

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

Contact Info

Product

Resources

About