Toxic Corneal Epithelial Edema from Exposure to High Atmospheric Concentration of Toluene Diisocyanates

Isocyanates

“…A chronic irritation syndrome can develop after exposure to levels exceeding 0.02 ppm: dyspnoe and a reduction ofthe lung function can occur [436], see also [437][438][439][440][441][442][443][444][445]. Repeated exposure to concentrations above 1 ppm can lead to a subchronic irritation syndrome.…”

Anthropogenic Compounds

“…A chronic irritation syndrome can develop after exposure to levels exceeding 0.02 ppm: dyspnoe and a reduction ofthe lung function can occur [436], see also [437][438][439][440][441][442][443][444][445]. Repeated exposure to concentrations above 1 ppm can lead to a subchronic irritation syndrome.…”

Isocyanates and respiratory disease: Current status

“…Skin and mucous membranes. Isocyanate solutions are irritant to skin and mucous membranes and may cause contact dermatitis [Mowe, 19801. Exposure to aerosols may cause oculorhinitis [Luckenbach and Kielar, 1980;Paggiaro et al, 19851. Conducting airways. Peters and Murphy [ 19701 identified four general patterns of airway response to TDI in man: (i) chemical bronchitis (following high doses), (ii) isocyanate asthma (in "sensitized" subjects), (iii) acute asymptomatic deterioration in airway function during a work shift, and (iv) chronic deterioration in airway function with prolonged low levels of exposure.…”

“…Isocyanate solutions are irritant to skin and mucous membranes and may cause contact dermatitis [Mowe, 19801. Exposure to aerosols may cause oculorhinitis [Luckenbach and Kielar, 1980; Paggiaro et al, 19851. Conducting airways.…”