Toxic compounds produced by cyanobacteria belonging to several species of the order Nostocales: A review

Nowruzi, Bahareh; Porzani, Samaneh Jafari

doi:10.1002/jat.4088

Cited by 36 publications

(19 citation statements)

References 281 publications

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“…The mode of action of these antimicrobial substances is basically different from the metabolite per se. Nowruzi & Porzani (2021) suggested that the cyanobacteria-derived bioactive metabolites could interfere with signal transduction (either via the activation or blockage of ionic channels or by targeting signaling proteins), resulting in apoptosis via the disruption of cytoskeletal proteins and the inhibition of membrane transporters, receptors, and enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…The ability of cyanobacterial taxa to produce cyanotoxins has been documented in different genera, mostly allocated within the orders Chroococcales, Oscillatoriales, and Nostocales (Cirés et al, 2017;Kust et al, 2018;Shishido et al, 2019;Nowruzi & Porzani, 2021). Microcystins (MCs), which are cyclic heptapeptides and the most prevalent class of cyanotoxins, are primarily characterized by the presence of the unique amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10phenyldeca-4,6 dienoic acid (Adda) (Sivonen, 1990).…”

Section: Introductionmentioning

confidence: 99%

“…To date, 279 MC variants have been identified, with the most common types being MC-LR, MC-LA, and MC-RR (Bouaïcha et al, 2019). The first variant has been reported as the most potent hepatotoxin (Nowruzi & Porzani, 2021). The presence of MCs in the true-branching heterocytous cyanobacterium W. prolifica remains an unclear and challenging topic, especially regarding the strains isolated from desert soils (Abed et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin–LR Biosynthesis

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin–LR Biosynthesis

et al. 2021

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“…They may contain potent hepato-and neurotoxic, as well as derma-and cytotoxic agents produced by strains of several cyanobacterial genera. Numerous cases of fatal animal poisonings, attributed to these toxins, have been reported around the globe over the past decades [21][22][23]. In freshwaters, blooms containing hepatotoxic agents are more frequent than those containing neurotoxins [24].…”

Section: Introductionmentioning

confidence: 99%

A Novel Potentially Toxic Cyanobacterial Species From the Genus Desmonostoc, Desmonostoc Alborizicum sp. nov., Iisolated From a Water Supply System of IranA

Nowruzi

Becerra-Absalón

2022

Preprint

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A cyanobacterial mat colonizing the wall of a qanat was found to be responsible for damages affecting the passage of water through the water supply system in Golestan province, Gorgan city, Iran. A qanat or kariz is a slightly sloping underground aqueduct used to transport water from water wells or aquifers to the surface for irrigation and drinking supply. A cyanobacterial strain was isolated from the mat and grown in BG11 liquid medium. Fragments of 16S rRNA, mcyG and mcyD genes were amplified and sequenced, as well as the 16S-23S internal transcribed spacer (ITS), from which secondary structures were analyzed. The obtained molecular data, together with morphological and physiological observations, were used to describe the new organism. The isolate was related to a morphotype of Nostoc sensu lato group, with similar characteristics of Desmonostoc, after microscopic inspections. The 16S rRNA phylogenetic analysis placed the isolate into the typical cluster of the recently proposed genus Desmonostoc. Morphological analysis revealed distinctive characteristic and secondary structures of 16S–23S rRNA (D1-D1´ and Box-B regions) derived from comparative analysis, which did not match known species of Desmonostoc. These results lead us to propose a novel Desmonostoc species, Desmonostoc alborizicum, which was described and compared with similar taxa. Furthermore, for the first time a potential toxic species of Desmonostoc was isolated from water supply, since the mcyD and mcyG genes of microcystin synthetase (mcy) cluster was successfully sequenced. The presence of the microcystin was confirmed by chemical analyses that also lead to the discovery of numerous other cyanobacterial secondary metabolites. We recognized substantial amounts of the potent microcystin variant microcystin-LR present in cell extracts of the Desmonostoc strain. Our findings contribute to a deeper understanding of diversity, systematics, and occurrence of Desmonostoc genus.

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“…Serious damage to water resources, marine products, living environment, and tourism resources can occur because of harmful cyanobacterial blooms (HCBs) in reservoirs around the world [1][2][3][4][5][6][7]. When HCBs appear in a reservoir, appearance and musty odor problems can make humans uncomfortable.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rainfall and pH on Musty Odor Produced in the Sanbe Reservoir

Kim

Hayashi

Masuki

et al. 2021

Water

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Harmful cyanobacterial blooms are continuously formed in water systems such as reservoirs and lakes around the world. Geosmin and 2-methylisoborneol (2-MIB) produced by some species of cyanobacteria have caused odor problems in the drinking water of the Sanbe Reservoir in Japan. Field observations were conducted for four years (2015–2019) to investigate the cause of this musty odor. It was found that geosmin was produced by Dolichospermum crassum and Dolichospermum planctonicum (cyanobacteria), and 2-MIB was due to Pseudanabaena sp. and Aphanizomenon cf. flos-aquae (cyanobacteria). Changes in water temperature and pH caused by rainfall were correlated with changes in the concentration of geosmin and 2-MIB. In particular, geosmin and 2-MIB tended to occur under low rainfall conditions. When there was low rainfall, the reservoir changed to an alkaline state because the phytoplankton consumed CO2 for photosynthesis. In an alkaline reservoir, dissolved inorganic carbon mainly existed in the form of bicarbonate (HCO3−). Thus, the results suggest that under such conditions in reservoirs, cyanobacteria grew easily because they could use both CO2 and HCO3− for photosynthesis. Specifically, our study suggests that in order for the musty odor problem in the reservoir to be solved, it is important that the pH of the reservoir be controlled.

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Toxic compounds produced by cyanobacteria belonging to several species of the order Nostocales: A review

Cited by 36 publications

References 281 publications

Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin–LR Biosynthesis

Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin–LR Biosynthesis

A Novel Potentially Toxic Cyanobacterial Species From the Genus Desmonostoc, Desmonostoc Alborizicum sp. nov., Iisolated From a Water Supply System of IranA

Effect of Rainfall and pH on Musty Odor Produced in the Sanbe Reservoir

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