Toxic and essential elements in placentas of swedish women

Osman, Katarina; Åkesson, Agneta; Berglund, Marika; Bremme, Katarina; Schütz, Andrejs; Ask, Karolin; Vahter, Marie

doi:10.1016/s0009-9120(00)00052-7

Cited by 248 publications

(175 citation statements)

References 22 publications

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“…Comparable relationships exist for cord blood lead. There are very few reports of a link between placental lead content and birth weight (14,15). Our observation of this association is not surprising, as it is expected from ORIGINAL RESEARCH the strong relationships found between placental lead and maternal, or cord, blood concentrations of this toxic metal (see Table III).…”

Section: Interpretation Of the Linear Regression Analysissupporting

confidence: 72%

“…Our observation of this association is not surprising, as it is expected from ORIGINAL RESEARCH the strong relationships found between placental lead and maternal, or cord, blood concentrations of this toxic metal (see Table III). While a relationship between placental and cord blood lead was noted by Osman et al (15), it was absent for the maternal blood and placental lead pair.…”

Section: Interpretation Of the Linear Regression Analysismentioning

confidence: 85%

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Elements in placenta and pregnancy outcome in arctic and subarctic areas

Odland

Nieboer

Romanova

et al. 2004

International Journal of Circumpolar Health

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Objectives. This paper describes a comprehensive assessment of the association of concentrations of essential and toxic elements in maternal and neonatal body fluids and the placenta as predictors of birth weight and newborn body mass index (BMIC) for deliveries in northern Norway and Russia. Study design. A prospective cross-sectional study of delivering women and their outcomes from different locations in Russian and Norwegian arctic and sub-arctic areas. Methods. Life-style information, blood, urine and placenta specimens were collected for 50 consecutive mother-infant pairs from hospital delivery departments in a total of six communities located in Finnmark, Norway, or the western arctic/subarctic regions of Russia. Questionnaire information was collected by individual interviews performed by trained health personnel. Pregnancy outcomes were verified by consulting medical records. Cadmium, copper, iron (as ferritin), nickel, lead, selenium and zinc were measured in maternal blood, serum or maternal urine; and in cord blood, or neonatal urine and placental tissue. Univariate and multivariate linear regression analysis and ANOVA were employed to explore associations between these clinical chemistry outcomes and birth weight and BMIC. Results. A number of significant relationships were evident between: placental and maternal blood cadmium (p < 0.005); cord and maternal blood lead (p < 0.001); placental and maternal blood lead (p < 0.001); placental and cord-blood lead (p < 0.001); placental and maternal serum, or blood, selenium (p < 0.001); and placental and maternal serum copper (p < 0.001). Maternal body mass index (BMI), maternal age, placental lead, or maternal blood lead, and smoking were retained as predictors of birth weight and BMIC in the multivariate modelling. Birth weights in both countries were normally distributed. ELEMENTS IN PLACENTA AND PREGNANCY OUTCOME IN ARCTIC AND SUBARCTIC AREAS

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Section: Interpretation Of the Linear Regression Analysissupporting

confidence: 72%

Section: Interpretation Of the Linear Regression Analysismentioning

confidence: 85%

Elements in placenta and pregnancy outcome in arctic and subarctic areas

Odland

Nieboer

Romanova

et al. 2004

International Journal of Circumpolar Health

View full text Add to dashboard Cite

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“…Butler Walker et al, 2006;Butler Walker et al, 2003;Dallaire et al, 2003;Hamel et al, 2003;Osman et al, 2000) All of the measured OCs in our study are stored in fat tissue over many years and have fairly long half-lives ranging between 5 and 15 years for PCBs, 4 to 12 years for dioxins/furans (Patandin et al, 1999), 9 years for p,p′-DDE (Hunter et al, 1997) and about 3 to 4 years for HCB (Pierik et al, 2007). In pregnant women, the mobilization of these pollutants can be enhanced.…”

Section: Introductionmentioning

confidence: 50%

“…All measured pollutants are known to pass through the placenta into the umbilical cord (Butler Walker et al, 2003;Osman et al, 2000). Lead can easily cross the placental barrier (Raghunath et al, 2000).…”

Section: Cord Blood Pollutant Levelsmentioning

confidence: 99%

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Organochlorine and heavy metals in newborns: Results from the Flemish Environment and Health Survey (FLEHS 2002–2006)

Koppen

Hond

Nelen

et al. 2009

Environment International

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a b s t r a c t a r t i c l e i n f oTo collect regional information on internal levels of pollutants in humans in Flanders, 1196 mother-child pairs were systematically recruited in 2002-2003 via 25 maternities across Flanders. Cd, Pb, PCB congeners 118, 170, 138, 153 and 180, p,p′-DDE -a key metabolite of DDT-and hexachlorobenzene (HCB) were measured in cord blood or plasma. Cd was detected in 64% of the samples (geometric mean 0.21 µg/L cord blood). p,p′-DDE (110 ng/g plasma lipids) and Pb (14.7 µg/L blood), were measurable in nearly all samples. The individual PCB congeners could be detected in 40 to 81% of the newborns (138 + 153 + 180 = 64.4 ng/g plasma lipids). HCB (18.9 ng/g plasma lipids) and dioxin-like compounds measured by DR-CALUX® (23 pg CALUX-TEQ/g lipids) were above detection limit in more than 75% of the samples. Age and smoking habits of the mothers, did not influence the cord blood Pb and Cd levels. The organochlorines increased 4 to 9% per year of the mother's age (partial R 2 = 0.05 to 0.22). Mothers had 2.6% less PCBs in cord blood (partial R 2 = 0.02) for each unit increase in pre-pregnancy BMI. Season of delivery, breastfeeding previous children or consumption of local dairy products, were minor determinants. Up to 20% of the variability in organochlorine concentrations was explained by residence area. It was concluded that the place of birth in Flanders is an important determinant of the load of pollutants measured at the start of life. This underlines the validity of human biomonitoring on (relatively) small geographical scale.

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