Toxic Advanced Glycation End-Products Inhibited Axonal Elongation Mediated by β-Tubulin Aggregation in Mice Optic Nerve
Hayahide Ooi,
Ayako Furukawa,
Masayoshi Takeuchi
et al.
Abstract:Advanced glycation end-products (AGEs) form through non-enzymatic glycation of various proteins. Optic nerve degeneration is a frequent complication of diabetes, and retinal AGEs accumulation is strongly linked to diabetic retinopathy development. Type 2 diabetes mellitus (T2DM) is a major risk factor for Alzheimer's disease (AD), with patients often exhibiting optic axon degeneration in the nerve fiber layer. Notably, a gap exists in our understanding of how AGEs contribute to neuronal degeneration i… Show more
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