By means of the technic for measuring resonant converse magnetoelectric (CME) effect, the mechanical loss of PZT/Terfenol-D/PZT tri-layer symmetric magnetoelectric laminated composites under multi-physical field loads such as bias magnetic field, driven voltage and ambient temperature is systematically measured in this paper. The experimental results show that the mechanical loss in CME effect increases initially with the increase of the bias magnetic field, and approaches to a broad maximum value at 250–500 Oe. Further increasing bias magnetic field leads to the decrease of mechanical loss. The mechanical loss increases rapidly with the increase of driven voltage amplitude, especially in the medium magnitude of the bias magnetic field. While, there is little influence of voltage on the mechanical loss under the higher bias magnetic fields. Importantly, the mechanical loss increases monotonically as the increase of ambient temperature. The research results of the mechanical loss under multi-physics fields in this paper can provide a basic principle of CME improvement by reducing the mechanical loss. Therefore, this research is quite significant to the CME based applications, such as, magnetoelectric transducers, magnetoelectric microwave devices, multiferroic antennas and so on.