Towards the elaboration of new gold-based optical theranostics

Abstract

Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.

Gold(I)–Coumarin–Caffeine‐Based Complexes as New Potential Anti‐Inflammatory and Anticancer Trackable Agents

“…Another explanation could be that the proximity of the coumarin to the imidazole ring may cause a photoinduced electron‐transfer phenomenon, but ligand 1 displays an interesting quantum yield. Otherwise, it is worth noting that, as observed in previous studies, coordination to the gold(I) ion does not quench the fluorescence, but even increases the quantum yields of 1 and 2 by a factor of two.…”

Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules

“…Numerous strategies explored the attachment of a targeting ligand (i.e. sugars and peptides) through S-Au bonds (Bertrand et al, 2014;Doulain et al, 2015). Although some drawbacks, particular promising are those exploiting these bonds for the functionalization with molecules for biosensing, anticancer drug delivery (i.e.…”

Synthesis and Biological Evaluation of Homogeneous Thiol‐Linked NHC*‐Au‐Albumin and ‐Trastuzumab Bioconjugates

“…In addition, a number of strategies explored the attachment of a targeting ligand (i.e., sugars and peptides) through S−Au I bonds. However, functionalisation of the complex with a directing ligand has often led to a decrease in activity . A number of reviews summarizing the role of NHC−Au and S−Au conjugates in biomedicine, in particular as anticancer agents, have been published …”

“…However,f unctionalisation of the complex with ad irecting ligand has often led to ad ecrease in activity. [14][15][16] An umber of reviews summarizing the role of NHCÀAu and SÀAu conjugates in bio- medicine, in particulara sa nticancer agents, have been published. [17][18][19][20] This study shows av ersatile way to synthesise NHC*ÀAuÀSprotein bioconjugates by cysteine-selective gold protein metallation.…”