Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications

Liu, Yupeng; Tan, B. T. G.

doi:10.1016/j.msec.2014.06.003

Cited by 178 publications

(114 citation statements)

References 74 publications

(125 reference statements)

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“…Hydrophilic block segments of either PEG, poly(acrylic acid) (PAA), poly(2-ethyl-2-oxazoline) (PEtOz), poly( N -isopropylacrylamide) (PNIPAAm), or poly( N , N -dimethylamino-2-ethyl methacrylate) (PDMAEMA) conjugated to the hydrophobic PCL segment have been used to formulate micelles. 146 For example, RGD-functionalized PCL–PEG diblock copolymers were used to formulate doxorubicin-loaded micelles for targeting drug delivery. 147 There are numerous examples of di- and triblock polymers synthesized with PCL polymers, and further examples of PCL diblock micelles used in controlled-release drug delivery applications have been reviewed.…”

Section: Biodegradable Polymers In Controlled Release Drug Deliverymentioning

confidence: 99%

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

et al. 2016

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Section: Biodegradable Polymers In Controlled Release Drug Deliverymentioning

confidence: 99%

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

et al. 2016

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“…Due to its exceptional qualities, such as its biocompatibility, low immunogenicity, hydrolysis under physiological conditions, and FDA approval for clinical use, poly( ε -caprolactone) (PCL) is another synthetic polyester based on hydroxyalkanoic acids that has attracted intense attention in tissue engineering. This polymer is used either alone, as hydrophobic PCL, or as a PCL-containing amphiphilic block copolymer when in combination with other agents, resulting in improved performance in certain applications [70,79,80]. …”

Section: Biomaterials For Tissue Engineeringmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

875

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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“…A, B blocks can be further arranged to form alternating and tapered block copolymers [12]. Amphiphilic block copolymers are composed of hydrophobic and hydrophilic parts which cause them to cluster and form micelles and can be used in drug delivery and tissue engineering [13]. Multi-arm block copolymers have several branches attached to a common core and some of them are H-shaped [14], star-shaped [15], miktoarms [16].…”

Section: Block Copolymersmentioning

confidence: 99%

Fabrication routes for one-dimensional nanostructures via block copolymers

2017

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Nanotechnology is the field which deals with fabrication of materials with dimensions in the nanometer range by manipulating atoms and molecules. Various synthesis routes exist for the one, two and three dimensional nanostructures. Recent advancements in nanotechnology have enabled the usage of block copolymers for the synthesis of such nanostructures. Block copolymers are versatile polymers with unique properties and come in many types and shapes. Their properties are highly dependent on the blocks of the copolymers, thus allowing easy tunability of its properties. This review briefly focusses on the use of block copolymers for synthesizing one-dimensional nanostructures especially nanowires, nanorods, nanoribbons and nanofibers. Template based, lithographic, and solution based approaches are common approaches in the synthesis of nanowires, nanorods, nanoribbons, and nanofibers. Synthesis of metal, metal oxides, metal oxalates, polymer, and graphene one dimensional nanostructures using block copolymers have been discussed as well.

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Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications

Cited by 178 publications

References 74 publications

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

Advancing biomaterials of human origin for tissue engineering

Fabrication routes for one-dimensional nanostructures via block copolymers

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