Towards the Development of Delivery Systems of Bioactive Compounds With Eyes Set on Pharmacokinetics

Silva, João; Marques‐da‐Silva, Dorinda; Lagoa, Ricardo

doi:10.1016/b978-0-12-821185-4.00006-3

Cited by 3 publications

(5 citation statements)

References 74 publications

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“…The chemopreventive action of polyphenols is supported by plenty of in vitro data, as well as by animal studies and epidemiological evidence [164,176]. These compounds usually affect multiple targets, modulating different interconnected biochemical processes, so they can put forward robust mechanisms of action against carcinogenesis and stemnessassociated pathways [185,186]. The analysis of a group of 21 phenolic compounds and their interaction with cancer stem cell-related genes pointed to a selection of five high therapeutic potential compounds: resveratrol, curcumin, quercetin, epigallocatechin gallate (EGCG), and genistein [187].…”

Section: Polyphenolsmentioning

confidence: 99%

Cancer Stem Cells from Definition to Detection and Targeted Drugs

Ruszkowska-Ciastek,

Kwiatkowska,

Marques-da-Silva

et al. 2024

IJMS

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Cancers remain the second leading cause of mortality in the world. Preclinical and clinical studies point an important role of cancer/leukaemia stem cells (CSCs/LSCs) in the colonisation at secondary organ sites upon metastatic spreading, although the precise mechanisms for specific actions are still not fully understood. Reviewing the present knowledge on the crucial role of CSCs/LSCs, their plasticity, and population heterogeneity in treatment failures in cancer patients is timely. Standard chemotherapy, which acts mainly on rapidly dividing cells, is unable to adequately affect CSCs with a low proliferation rate. One of the proposed mechanisms of CSC resistance to anticancer agents is the fact that these cells can easily shift between different phases of the cell cycle in response to typical cell stimuli induced by anticancer drugs. In this work, we reviewed the recent studies on CSC/LSC alterations associated with disease recurrence, and we systematised the functional assays, markers, and novel methods for CSCs screening. This review emphasises CSCs’ involvement in cancer progression and metastasis, as well as CSC/LSC targeting by synthetic and natural compounds aiming at their elimination or modulation of stemness properties.

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Section: Polyphenolsmentioning

confidence: 99%

Cancer Stem Cells from Definition to Detection and Targeted Drugs

Ruszkowska-Ciastek,

Kwiatkowska,

Marques-da-Silva

et al. 2024

IJMS

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“…Stimuli-triggered release systems are designed to be reactive to various external factors like pH, temperature, or even the migration of cells (e.g., MMP-degradable cross-links). For more detailed explanations of drug delivery via biomaterial systems, readers are directed to reviews by Silva et al and Langer and Peppas. , These biomaterial release systems allow for local delivery of a drug or molecule, with systemic toxicity or off-target side effects that may arise from systemic delivery to the body. , …”

Section: Salient Properties For Biomaterials Designmentioning

confidence: 99%

Section: Salient Properties For Biomaterials Designmentioning

confidence: 99%

“…There are several categories of drug delivery systems that can be applied to biomaterials, which are summarized in Figure 3 and include diffusion controlled, chemically controlled, solvent activated, and stimuli triggered release. Diffusion-controlled release is mediated by a 77,78 These biomaterial release systems allow for local delivery of a drug or molecule, with systemic toxicity or offtarget side effects that may arise from systemic delivery to the body. 79,80 Biomaterial-based delivery also protects small molecules or proteins from degradation until they are released by serving as a barrier between the molecule and the immune system and is accomplished though functionalization or encapsulation of the molecule or protein by the material.…”

Section: Controlled Release Of Moleculesmentioning

confidence: 99%

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Biomaterial Design Inspired by Regenerative Research Organisms

Sapru

Dill

Simmons

2022

ACS Biomater. Sci. Eng.

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The efficacy of implanted biomaterials is largely dependent on the response of the host's immune and stromal cells. Severe foreign body response (FBR) can impede the integration of the implant into the host tissue and compromise the intended mechanical and biochemical function. Many features of FBR, including late-stage fibrotic encapsulation of implants, parallel the formation of fibrotic scar tissue after tissue injury. Regenerative organisms like zebrafish and salamanders can avoid fibrosis after injury entirely, but FBR in these research organisms is rarely investigated because their immune competence is much lower than humans. The recent characterization of a regenerative mammal, the spiny mouse (Acomys), has inspired us to take a closer look at cellular regulation in regenerative organisms across the animal kingdom for insights into avoiding FBR in humans. Here, we highlight how major features of regeneration, such as blastema formation, macrophage polarization, and matrix composition, can be modulated across a range of regenerative research organisms to elucidate common features that may be harnessed to minimize FBR. Leveraging a deeper understanding of regenerative biology for biomaterial design may help to reduce FBR and improve device integration and performance.

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“…Developing a good adsorbent material includes its cost-effectiveness, reusability, and biodegradability. The polysaccharide alginate and the synthetic polymer polycaprolactone (PCL) are biodegradable materials with multifunctional applications in the environmental and biomedical fields [17][18][19][20][21][22]. Alginate binds copper ions [23], and calcium alginate beads remove heavy metals from water media [18,19].…”

Section: Introductionmentioning

confidence: 99%

Removal of Hydrophobic Organic Pollutants and Copper by Alginate-Based and Polycaprolactone Materials

et al. 2022

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Organic pollutants (OPs) and heavy metals are environmental toxicants associated with great concerns. Decontamination processes are urgent for both, and the possibility to achieve their simultaneous removal from polluted waters is highly interesting. Additionally, in many cases, the effect of organic matter in the removal process is overlooked and must be considered. This work aimed to study the potential of alginate-based and polycaprolactone (PCL) materials to remove OPs and copper ions in the absence and presence of organic matter. The OPs investigated were the polycyclic aromatic hydrocarbons anthracene and benzo[a]pyrene, and the pesticide chlorpyrifos, both hydrophobic compounds. Copper (II) ions were used as a model of heavy metals. Alginate-based spheres were prepared by gelation, and PCL microparticles were obtained by oil/water emulsion solvent evaporation. The materials with the highest efficiencies for OP removal from aqueous solutions were those with activated carbon and PCL. Furthermore, the spheres with activated carbon could remove anthracene and copper simultaneously, even in the presence of humic acid. This work points to activated carbon–alginate spheres as a multifunctional adsorbent able to remove different pollutants and to PCL for potential applications in OP decontamination processes.

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Towards the Development of Delivery Systems of Bioactive Compounds With Eyes Set on Pharmacokinetics

Cited by 3 publications

References 74 publications

Cancer Stem Cells from Definition to Detection and Targeted Drugs

Cancer Stem Cells from Definition to Detection and Targeted Drugs

Biomaterial Design Inspired by Regenerative Research Organisms

Removal of Hydrophobic Organic Pollutants and Copper by Alginate-Based and Polycaprolactone Materials

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