Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface

Dukovski, Bisera Jurišić; Ljubica, Josip; Kocbek, Petra; Kučuk, Maša Safundžić; Krtalić, Iva; Hafner, Anita; Pepić, Ivan; Lovrić, Jasmina

doi:10.1016/j.ijpharm.2023.122622

Cited by 5 publications

(5 citation statements)

References 39 publications

(54 reference statements)

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“…This mechanism effectively safeguards and nurtures the tear film. 74 Kinnunen et al conducted a study assessing the tolerability of Cationorm using in vitro testing on human corneal epithelial cells (HCE cells). The HCE cell culture line was used to evaluate the impact of Cationorm on cytotoxicity, cellular morphology, and inflammatory responses.…”

Section: Commercialized Nanoemulsion Products For the Treatment Of Oc...mentioning

confidence: 99%

Oil-in-water nanoemulsions for glaucoma treatment: An insight into the latest trends

Kishore,

Mahor,

Singh

et al. 2024

Bioimpacts

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Glaucoma is a serious eye disease characterized by elevated intraocular pressure, which can ultimately lead to blindness, making it the second leading cause of blindness worldwide, following cataracts. The condition is associated with various risk factors and primarily affects the optic nerve. To treat glaucoma, a range of approaches, both traditional and innovative, have been employed. Recently, there has been a significant focus on nanoemulsions as a promising avenue for treatment. This review underscores the advantages of using oil-in-water nanoemulsions for ocular drug delivery, showcasing their superiority in terms of enhanced bioavailability and stability compared with other dispersion systems. This review also delves into the limitations inherent in traditional drug formulations, elucidates the mechanisms governing drug release, explores the pivotal role of surfactants, and examines the landscape of granted patents in this domain. By addressing these critical aspects, the review offers invaluable insights into the treatment of glaucoma, shedding light on innovative approaches that hold great promise in the fight against this debilitating eye condition. During our search, it was noticed that despite the existence of commendable research in the field of ocular nanoemulsions, particularly in the context of glaucoma along with granted patents, the commercialized nanoemulsion formulations for glaucoma is not yet exist.

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Section: Commercialized Nanoemulsion Products For the Treatment Of Oc...mentioning

confidence: 99%

Oil-in-water nanoemulsions for glaucoma treatment: An insight into the latest trends

Kishore,

Mahor,

Singh

et al. 2024

Bioimpacts

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“…Currently, there is limited guidance on methods for evaluating corneal and conjunctival drug penetration in diffusion cell and permeation assays, e.g., criteria for tissue selection, tissue preparation, membrane loading with drug, receptor or dissolution media, and agitation or flow rate to be used in such experiments. In some areas, such as the development of artificial tears for in vitro studies, some progress has already been made in the past (7,8). However, the focus of most of the reported studies was not on the development of an IVRT.…”

Section: Biorelevance Of In Vitro Test Conditionsmentioning

confidence: 99%

Testing the In Vitro Product Performance of Mucosal Drug Products: View of the USP Expert Panel

Klein,

Sakagami,

et al. 2023

Dissolution Technol.

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Performance testing of mucosal drug products presents the user with a multitude of challenges. Not only are there many different dosage forms to be distinguished, but also a wide variety of administration routes. The target action effect (local or systemic) is another factor to be considered. Thus, it quickly becomes apparent that there will never be a universal performance test, but the question arises just as quickly whether the method to be used should rather depend on the dosage form or the place of application, or even whether decisions must be made on an individual basis. This Stimuli article is one of a series of Stimuli articles on product performance testing, which focuses on methodological approaches and challenges in the field of performance testing of mucosal drug products. The article should be viewed as a supplement to, but also a critical discussion of the methods listed in USP general chapter Mucosal Drug Products-Performance Tests <1004>. With consideration of major physiologic aspects at the site of administration and the types of dosage forms to be studied, limitations of the methods described here and the need for methodologic updates or innovations are identified. Furthermore, suggestions are made for future activities, all aimed at developing robust, discriminatory, and meaningful test methods for the wide variety of mucosal drug products.

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“…It is reasonable to anticipate that these compounds would readily interact with tear film lipids, thereby modulating the interactions between the tear film and latanoprost. Similarly, the mechanism of interactions between complex delivery vehicles, in particular, the nanoemulsions with the tear film, is not well understood . These topics are explored in the present work.…”

Section: Introductionmentioning

confidence: 95%

“…Similarly, the mechanism of interactions between complex delivery vehicles, in particular, the nanoemulsions with the tear film, is not well understood. 16 These topics are explored in the present work.…”

Section: Introductionmentioning

confidence: 98%

Comparative Study of Latanoprost Drug Delivery Systems for Glaucoma Treatment and Their Interaction with the Tear Film Lipid Layer Models

Saija,

Vazdar,

Pajerski

et al. 2023

Mol. Pharmaceutics

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Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface

Cited by 5 publications

References 39 publications

Oil-in-water nanoemulsions for glaucoma treatment: An insight into the latest trends

Oil-in-water nanoemulsions for glaucoma treatment: An insight into the latest trends

Testing the In Vitro Product Performance of Mucosal Drug Products: View of the USP Expert Panel

Comparative Study of Latanoprost Drug Delivery Systems for Glaucoma Treatment and Their Interaction with the Tear Film Lipid Layer Models

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