Towards specific DNA aptamers which bind and inhibit WWP1 HECT ubiquitin ligase in the osteoblast

Tucker, W. O.

doi:10.5353/th_b5108666

Cited by 1 publication

(1 citation statement)

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“…The discovery of aptamers is indeed a valuable contribution towards the empirical determination of the multifunctional nature of NAs [1,7]. Essentially, aptamers are small, often ranging between 20 to 60 nucleotides, single-stranded DNA or RNA oligonucleotides that are capable of binding target molecules not only with high specificity but also with high affinity [8,9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Updates on Aptamer Research

Ali

Elsherbiny

Emara

2019

IJMS

129

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For many years, different probing techniques have mainly relied on antibodies for molecular recognition. However, with the discovery of aptamers, this has changed. The science community is currently considering using aptamers in molecular targeting studies because of the many potential advantages they have over traditional antibodies. Some of these possible advantages are their specificity, higher binding affinity, better target discrimination, minimized batch-to-batch variation, and reduced side effects. Overall, these characteristics of aptamers have attracted scholars to use them as molecular probes in place of antibodies, with some aptamer-based targeting products being now available in the market. The present review is aimed at discussing the potential of aptamers as probes in molecular biology and in super-resolution microscopy.

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