Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring

Busch, David R.; Lin, Wei; Goh, Chia Chieh; Gao, Feng; Larson, Nicholas; Wahl, Joseph; Bilfinger, Thomas V.; Yodh, Arjun G.; Floyd, Thomas F.

doi:10.1371/journal.pone.0251271

Cited by 4 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 432 , 433 , 438 – 441 In a related vein, modifications in diffuse optical hardware have accelerated the use of NIRS and DCS to monitor local spinal cord hemodynamics intraoperatively. This approach has been tested in ovine 442 – 444 and porcine 445 , 446 models so far, showing the feasibility and safety of using optical spectroscopy to monitor different sites of the spinal cord and identify early ischemia that can result in paralysis and paraparesis. 442 , 446 , 447 …”

Section: Clinical Applications Of Optical Spectroscopy and Imagingmentioning

confidence: 99%

“…This approach has been tested in ovine 442 – 444 and porcine 445 , 446 models so far, showing the feasibility and safety of using optical spectroscopy to monitor different sites of the spinal cord and identify early ischemia that can result in paralysis and paraparesis. 442 , 446 , 447 …”

Section: Clinical Applications Of Optical Spectroscopy and Imagingmentioning

confidence: 99%

“…This approach has been tested in ovine [442][443][444] and porcine 445,446 models so far, showing the feasibility and safety of using optical spectroscopy to monitor different sites of the spinal cord and identify early ischemia that can result in paralysis and paraparesis. 442,446,447 Overall, the exciting results outlined in Secs. 5.1-5.4 as well as countless other examples suggest that optics-based neuromonitoring can significantly impact patient care in a wide range of clinical settings.…”

Section: Surgical Monitoringmentioning

confidence: 99%

See 2 more Smart Citations

Optical imaging and spectroscopy for the study of the human brain: status report

et al. 2022

Self Cite

View full text Add to dashboard Cite

. This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly applicable to animal studies, here, we highlight optical spectroscopy and imaging methods relevant to noninvasive human brain studies. We outline current state-of-the-art technologies and software advances, explore the most recent impact of these technologies on neuroscience and clinical applications, identify the areas where innovation is needed, and provide an outlook for the future directions.

show abstract

Section: Clinical Applications Of Optical Spectroscopy and Imagingmentioning

confidence: 99%

Section: Clinical Applications Of Optical Spectroscopy and Imagingmentioning

confidence: 99%

Section: Surgical Monitoringmentioning

confidence: 99%

See 1 more Smart Citation

Optical imaging and spectroscopy for the study of the human brain: status report

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…DCS blood flow indices have been validated against a variety of gold standard modalities including Doppler ultrasound [ 10 ], computed tomography (CT) [ 11 ] and Magnetic Resonance Imaging (MRI) [ 12 ]. DCS’s utility has been demonstrated for noninvasive deep-tissue blood flow measurements in adult/pediatric brain [ 8 ], [ 10 ], [ 13 ], [ 14 ], [ 15 ], in muscle [ 16 ], [ 17 ] and in spinal cord [ 18 ], [ 19 ], [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Lossless Compressed Sensing of Photon Counts for Fast Diffuse Correlation Spectroscopy

Biswas

Parthasarathy

2022

IEEE Access

View full text Add to dashboard Cite

Diffuse Correlation Spectroscopy (DCS), a noninvasive optical technique, measures deep tissue blood flow using avalanche photon counting modules and data acquisition devices such as FPGAs or correlator boards. Conventional DCS instruments use in-processor counter modules that consume 32 bits/channel which is inefficient for low-photon budget situations prevalent in diffuse optics. Scaling these photon counters for large-scale imaging applications is difficult due to bandwidth and processing time considerations. Here, we introduce a new, lossless compressed sensing approach for fast and efficient detection of photon counts. The compressed DCS method uses an array of binary-coded-decimal counters to record photon counts from 8 channels simultaneously as a single 32-bit number. We validate the compressed DCS approach by comparisons with conventional DCS in experiments on tissue simulating phantoms and invivo arm cuff occlusion. Lossless compressed DCS was implemented with 87.5% compression efficiency. In tissue simulating phantoms, it was able to accurately estimate a tissue blood flow index, with no statistically significant difference compared to conventional DCS. Compressed DCS also recorded blood flow in vivo, in human forearm, with signal-to-noise ratio and dynamic range comparable to conventional DCS. Lossless 87.5% efficient compressed sensing counting of photon counts meets and exceeds benchmarks set by conventional DCS systems, offering a low-cost alternative for fast (~100 Hz) deep tissue blood flow measurement with optics.

show abstract

“…Ischemic [27,33,34] • Duration and degree of ischemia can be titrated to grade both clinical injury and neuronal cell death on histology.…”

mentioning

confidence: 99%

Porcine Models of Spinal Cord Injury

Wathen,

Ghenbot,

Ozturk

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Large animal models of spinal cord injury may be useful tools in facilitating the development of translational therapies for spinal cord injury (SCI). Porcine models of SCI are of particular interest due to significant anatomic and physiologic similarities to humans. The similar size and functional organization of the porcine spinal cord, for instance, may facilitate more accurate evaluation of axonal regeneration across long distances that more closely resemble the realities of clinical SCI. Furthermore, the porcine cardiovascular system closely resembles that of humans, including at the level of the spinal cord vascular supply. These anatomic and physiologic similarities to humans not only enable more representative SCI models with the ability to accurately evaluate the translational potential of novel therapies, especially biologics, they also facilitate the collection of physiologic data to assess response to therapy in a setting similar to those used in the clinical management of SCI. This review summarizes the current landscape of porcine spinal cord injury research, including the available models, outcome measures, and the strengths, limitations, and alternatives to porcine models. As the number of investigational SCI therapies grow, porcine SCI models provide an attractive platform for the evaluation of promising treatments prior to clinical translation.

show abstract

Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring

Cited by 4 publications

References 40 publications

Optical imaging and spectroscopy for the study of the human brain: status report

Optical imaging and spectroscopy for the study of the human brain: status report

Lossless Compressed Sensing of Photon Counts for Fast Diffuse Correlation Spectroscopy

Porcine Models of Spinal Cord Injury

Contact Info

Product

Resources

About