Towards rabies elimination in the Asia-Pacific region: From theory to practice

Rupprecht, Charles E.; Abela-Ridder, Bernadette; Abila, Ronello; Amparo, Anna Charinna B.; Banyard, Ashley C.; Blanton, Jesse D.; Chanachai, Karoon; Dallmeier, Kai; Balogh, Katinka de; Vilas, Victor Del Rio; Ertl, Hildegund C. J.; Freuling, Conrad Martin; Hill, R. E.; Houillon, G; Jakava-Viljanen, Miia; Kasemsuwan, Suwicha; Léchenet, Jacques; Nel, Louis; Panichabhongse, Pranee; Rahman, Sira Abdul; Tantawichien, Terapong; Vandeputte, Joris; Viriyabancha, Wittawat; Vos, Ad; Wallace, Ryan M.; Yale, Gowri; Yurachai, Onphirul; Mueller, Thomas

doi:10.1016/j.biologicals.2020.01.008

Cited by 26 publications

(12 citation statements)

References 31 publications

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“…In combination with lessened ATP production, there is a decrease in mitophagy as a person ages (García-Prat et al, 2016), which not only contributes to unregulated inflammasome activity (Jang et al, 2018) but also an accumulation of mitochondria that may no longer produce energy efficiently. Mitophagy is a protective function of the cell that keeps inflammation at a manageable level by removing damaged mitochondria that could contribute to hyper inflammation, especially among already susceptible older patients.…”

Section: Quality Control Of Mitochondriamentioning

confidence: 99%

Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases

Ganji

Reddy

2021

Front. Aging Neurosci.

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The coronavirus disease 2019 (COVID-19) has become a deadly pandemic with surging mortality rates and no cure. COVID-19 is caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) with a range of clinical symptoms, including cough, fever, chills, headache, shortness of breath, difficulty breathing, muscle pain, and a loss of smell or taste. Aged individuals with compromised immunity are highly susceptible to COVID-19 and the likelihood of mortality increases with age and the presence of comorbidities such as hypertension, diabetes mellitus, cardiovascular disease, or chronic obstructive pulmonary disease. Emerging evidence suggests that COVID-19 highjacks mitochondria of immune cells, replicates within mitochondrial structures, and impairs mitochondrial dynamics leading to cell death. Mitochondria are the powerhouses of the cell and are largely involved in maintaining cell immunity, homeostasis, and cell survival/death. Increasing evidence suggests that mitochondria from COVID-19 infected cells are highly vulnerable, and vulnerability increases with age. The purpose of our article is to summarize the role of various age-related comorbidities such as diabetes, obesity, and neurological diseases in increasing mortality rates amongst the elderly with COVID-19. Our article also highlights the interaction between coronavirus and mitochondrial dynamics in immune cells. We also highlight the current treatments, lifestyles, and safety measures that can help protect against COVID-19. Further research is urgently needed to understand the molecular mechanisms between the mitochondrial virus and disease progression in COVID-19 patients.

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Section: Quality Control Of Mitochondriamentioning

confidence: 99%

Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases

Ganji

Reddy

2021

Front. Aging Neurosci.

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“…They proposed a cascading model of multiple parallel pathways connecting the auditory cortex, inferior colliculus, cochlear nucleus, and superior olivary nuclei (including a direct projection from the auditory cortex to neurons making up the medial olivocochlear pathway; Mulders and Robertson, 2000) as potential neural substrates for these findings (Figure 1D; Terreros and Délano, 2015). Here, we attempt to link the bodies of literature on intracortical top-down modulation for processing of complex sounds (which has primarily been done in humans, with some notable exceptions; García-Rosales et al, 2020;Yin et al, 2020) and corticofugal modulation of subcortical auditory processing regions (which has primarily been done in animals), to develop a better understanding of the potential role of corticofugal projections in the disambiguation of corrupted acoustic signals.…”

Section: Introductionmentioning

confidence: 99%

Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections

Asilador

Llano

2021

Front. Neural Circuits

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It has become widely accepted that humans use contextual information to infer the meaning of ambiguous acoustic signals. In speech, for example, high-level semantic, syntactic, or lexical information shape our understanding of a phoneme buried in noise. Most current theories to explain this phenomenon rely on hierarchical predictive coding models involving a set of Bayesian priors emanating from high-level brain regions (e.g., prefrontal cortex) that are used to influence processing at lower-levels of the cortical sensory hierarchy (e.g., auditory cortex). As such, virtually all proposed models to explain top-down facilitation are focused on intracortical connections, and consequently, subcortical nuclei have scarcely been discussed in this context. However, subcortical auditory nuclei receive massive, heterogeneous, and cascading descending projections at every level of the sensory hierarchy, and activation of these systems has been shown to improve speech recognition. It is not yet clear whether or how top-down modulation to resolve ambiguous sounds calls upon these corticofugal projections. Here, we review the literature on top-down modulation in the auditory system, primarily focused on humans and cortical imaging/recording methods, and attempt to relate these findings to a growing animal literature, which has primarily been focused on corticofugal projections. We argue that corticofugal pathways contain the requisite circuitry to implement predictive coding mechanisms to facilitate perception of complex sounds and that top-down modulation at early (i.e., subcortical) stages of processing complement modulation at later (i.e., cortical) stages of processing. Finally, we suggest experimental approaches for future studies on this topic.

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“…To increase vaccination coverage in these hard-to-reach dogs, the concept of oral rabies vaccination (ORV) of dogs as a complementary tool to mass parenteral dog vaccination has been proposed (14). Unfortunately, it is still the most underused of all tools in the fight against dog-mediated rabies (15), however, the concept has gained reviving interest in recent years (16)(17)(18)(19)(20). In fact, by targeting free-roaming and partly inaccessible dogs, ORV does not only increase the vaccination coverage of the overall dog population (16,21) but also reaches those animals that are considered to play a key role in the transmission of rabies (16,22,23).…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity of the Oral Rabies Vaccine Strain SPBN GASGAS in Dogs Under Field Settings in Namibia

Molini

Hassel

Ortmann³

et al. 2021

Front. Vet. Sci.

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Dog-mediated rabies is endemic throughout Africa. While free-roaming dogs that play a crucial role in rabies transmission are often inaccessible for parenteral vaccination during mass dog vaccination campaigns, oral rabies vaccination (ORV) is considered to be a promising alternative to increase vaccination coverage in these hard-to-reach dogs. The acceptance of ORV as an efficient supplementary tool is still low, not least because of limited immunogenicity and field trial data in local dogs. In this study, the immunogenicity of the highly attenuated 3rd-generation oral rabies vaccine strain SPBN GASGAS in local free-roaming dogs from Namibia was assessed by determining the immune response in terms of seroconversion for up to 56 days post-vaccination. At two study sites, free-roaming dogs were vaccinated by administering the vaccine either by direct oral administration or via a vaccine-loaded egg bait. Pre- and post-vaccination blood samples were tested for rabies virus neutralizing as well as binding antibodies using standard serological assays. A multiple logistic regression (MLR) analysis was performed to determine a possible influence of study area, vaccination method, and vaccine dose on the seroconversion rate obtained. About 78% of the dogs vaccinated by the oral route seroconverted (enzyme-linked immunosorbent assay, ELISA), though the seroconversion as determined by a rapid fluorescence focus inhibition test (RFFIT) was much lower. None of the factors examined had a significant effect on the seroconversion rate. This study confirms the immunogenicity of the vaccine strain SPBN GASGAS and the potential utility of ORV for the control of dog-mediated rabies in African dogs.

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Towards rabies elimination in the Asia-Pacific region: From theory to practice

Cited by 26 publications

References 31 publications

Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases

Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases

Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections

Immunogenicity of the Oral Rabies Vaccine Strain SPBN GASGAS in Dogs Under Field Settings in Namibia

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