Towards precision pain medicine for pain after cancer: the Cancer Pain Phenotyping Network multidisciplinary international guidelines for pain phenotyping using nociplastic pain criteria

Nijs, Jo; Lahousse, Astrid; Fernández‐de‐las‐Peñas, César; Madeleine, Pascal; Fontaine, Christel; Nishigami, Tomohiko; Desmedt, Christine; Vanhoeij, Marian; Mostaqim, Kenza; Cuesta-Vargas, Antonio; Kapreli, Eleni; Bilika, Paraskevi; Polli, Andrea; Leysen, Laurence; Elma, Ömer; Roose, Eva; Rheel, Emma; Yılmaz, Sevilay Tümkaya; Baets, Liesbet De; Huysmans, Eva; Türk, Ali; Saraçoğlu, İsmail

doi:10.1016/j.bja.2022.12.013

Cited by 9 publications

(1 citation statement)

References 94 publications

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“…Central sensitizitation is defined as an amplification of neural signalling within the central nervous system that elicits pain hypersensitivity [ 6 ]. The need for early recognition of central sensitization in patients with chronic pain was raised by the International Association for the Study of Pain (IASP), who recently introduced the term “nociplastic pain” as a third mechanistic pain descriptor in addition to nociceptive (pain attributable to the activation of the peripheral receptive terminals of primary afferent neurones in response to noxious chemical, mechanical, or thermal stimuli) and neuropathic (pain caused by a primary lesion or disease of the somatosensory nervous system) pain [ 7 ]. Nociplastic pain is defined by the IASP as “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain” [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Physical Exercise and Motor Activity on Oxidative Stress and Inflammation in Post-Mastectomy Pain Syndrome

Calapai¹,

Puzzo²,

Bova³

et al. 2023

Antioxidants

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It is estimated that 10–50% of interventions can generate persistent post-surgical pain. Chronic post-mastectomy pain is a condition persisting for at least three months after surgery. It has been shown that physical activity in the cancer patient allows the improvement of the pain symptom. The aim of this study was to evaluate the effects of physical activity on the intensity and interference of chronic pain in the quality of life of women underwent mastectomy needed for breast cancer removal. The secondary objective was to measure the effects of physical activity on inflammatory and oxidative markers in the same population. A Numeric Rating Scale (NRS) was used to assess pain intensity, and Brief Inventory Pain (BIP) was used for assessing interference of pain in quality of life. Physical activity was measured with the International Physical Activity Questionnaire (IPAQ). Inflammatory mediators such as interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, c-reactive protein (CRP), and biomarkers of oxidative stress malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were evaluated in the blood of patients. All the evaluations were performed after three and six months after surgery. Results showed that adequate physical activity can diminish intensity and interference of pain and that these effects are associated with a reduction of blood biomarkers of inflammation.

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Section: Introductionmentioning

confidence: 99%