Towards personalizing cognitive remediation therapy: Examining moderators of response for euthymic people with bipolar disorder

The Efects of Cognitive Remediation Therapy in Bipolar Disorder Patients

“…Their other findings were medium effect size for global cognition, small-to-medium effect sizes for individual cognitive domains, and medium improvement in psychosocial functioning. 31 These results were in line with Strawbridge et al, which state that CR largely improves goal attainment, psychosocial functioning, IQ, working memory, and executive function at both posttreatment (week 13) and follow-up (week 25). From the participant's perspective, CR itself also had good acceptability (95%), good durations of sessions (86%), and good at increasing awareness (76%).…”

“…28,29 However, the effect was no longer significant at the 6 months follow-up and only the subjective cognitive function persists. 28 CR also could improve psychosocial function by engaging in real-world activities and navigating workplace situations, 14 and medium improvement were shown 31 . Unfortunately, there were no recent studies that discuss the effects of CR on language and perceptual-motor function.…”

Can biomarkers aid the stratification of individuals with mood disorders for cognitive remediation interventions?

“…In these cases, higher pre‐CR levels predicted better subsequent outcomes, interacting with CR compared with usual care, and were increased further by CR compared with usual care; (III) Non‐biological (cognitive/clinical/demographic): In relation to cognitive predictors, data from the Strawbridge et al trial found cognition at baseline was the only predictor of CR‐related cognitive change (i.e. poor cognition at baseline was associated with better CR response) out of a total of 16 candidate predictors (cognitive, functional, demographic, clinical) 5 . In contrast, data from the RCTs by Ott et al and Douglas et al showed no associations between baseline objective (executive function 1 and global cognition 3 ) and subjective cognition and CR‐associated improvement in cognition.…”

Cognitive rehabilitation in bipolar spectrum disorder: A systematic review

“…Bipolar disorder (BD) is a serious mental condition that has been identified as the 17th leading cause of disability among all diseases ( Carvalho et al, 2020 ). Cognitive dysfunction affects approximately 70% of BD patients, even in the euthymic phase ( Bora et al, 2016 , Ehrminger et al, 2021 , Tsapekos et al, 2022 ), significantly impacting daily functioning. Neurocognitive domains most affected by BD include verbal memory, attention, executive functions (such as behavior inhibition and cognitive flexibility), and social cognition (e.g., theory of mind and emotion recognition) ( Kahani et al, 2013 , Gomes et al, 2017 , Ershad Sarabi et al, 2020 , Liu et al, 2021 ).…”